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. 1982 Jul;37(1):155–159. doi: 10.1128/iai.37.1.155-159.1982

Strains of Neisseria meningitidis isolated from patients and their close contacts.

C E Frasch, L F Mocca
PMCID: PMC347504  PMID: 6809624

Abstract

Neisseria meningitidis isolates from contacts, mostly family members, of 27 unrelated meningococcal disease patients were examined by serogrouping, serotyping, and a recently described sodium dodecyl sulfate-polyacrylamide gel electrophoresis typing procedure. Most of the isolates were serogroup B or C. Serotyping and sodium dodecyl sulfate-polyacrylamide gel electrophoresis typing now provide a more precise means than serogrouping for determining the epidemiological relationships among patient isolates and those of related carriers. In 70% of the families studied, all contact carriers had strains indistinguishable from that of the patient. In the other 30%, more than one meningococcal strain was recovered from the family. Sixty percent of the carrier isolates were recovered from adults. It was found that, among household contacts, the mother was most likely and the father was least likely to carry the disease isolate. Nonhousehold contacts were least likely to carry the disease isolate.

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Selected References

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  1. Ashton F. E., Ryan A., Diena B. B., MacKenzie A. M., Chan F. Serotypes among Neisseria meningitidis serogroups B and C strains isolated in Canada. Can J Microbiol. 1980 Dec;26(12):1480–1488. doi: 10.1139/m80-245. [DOI] [PubMed] [Google Scholar]
  2. CRAGG J., BENNETT E. F. Meningococcal meningitis; a family study. Lancet. 1959 Jan 31;1(7066):248–249. doi: 10.1016/s0140-6736(59)90069-8. [DOI] [PubMed] [Google Scholar]
  3. Craven D. E., Frasch C. E., Mocca L. F., Rose F. B., Gonzalez R. Rapid serogroup identification of Neisseria meningitidis by using antiserum agar: Prevalence of serotypes in a disease-free military population. J Clin Microbiol. 1979 Sep;10(3):302–307. doi: 10.1128/jcm.10.3.302-307.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Craven D. E., Frasch C. E., Robbins J. B., Feldman H. A. Serogroup identification of Neisseria meningitidis: comparison of an antiserum agar method with bacterial slide agglutination. J Clin Microbiol. 1978 May;7(5):410–414. doi: 10.1128/jcm.7.5.410-414.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. De Maeyer S., Seba J. M., Reginster G. Epidemiology of meningococcal meningitis in Belgium. J Infect. 1981 Mar;3(1 Suppl):63–70. doi: 10.1016/s0163-4453(81)80010-2. [DOI] [PubMed] [Google Scholar]
  6. Farries J. S., Dickson W., Greenwood E., Malhotra T. R., Abbott J. D., Jones D. M. Meningococcal infections in Bolton, 1971-74. Lancet. 1975 Jul 19;2(7925):118–120. doi: 10.1016/s0140-6736(75)90016-1. [DOI] [PubMed] [Google Scholar]
  7. Foster M. T., Jr, Sanders E., Ginter M. Epidemiology of sulfonamide-resistant meningococcal infections in a civilian population. Am J Epidemiol. 1971 May;93(5):346–353. doi: 10.1093/oxfordjournals.aje.a121267. [DOI] [PubMed] [Google Scholar]
  8. Frasch C. E., Chapman S. S. Classification of Neisseria meningitidis group B into distinct serotypes. 3. Application of a new bactericidal-inhibition technique to distribution of serotypes among cases and carriers. J Infect Dis. 1973 Feb;127(2):149–154. doi: 10.1093/infdis/127.2.149. [DOI] [PubMed] [Google Scholar]
  9. Frasch C. E., Chapman S. S. Classification of Neisseria meningitidis group B into distinct serotypes. I. Serological typing by a microbactericidal method. Infect Immun. 1972 Jan;5(1):98–102. doi: 10.1128/iai.5.1.98-102.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Frasch C. E., Chapman S. S. Classification of Neisseria meningitidis group B into distinct serotypes. II. Extraction of type-specific antigens for serotyping by precipitin techniques. Infect Immun. 1972 Aug;6(2):127–133. doi: 10.1128/iai.6.2.127-133.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Frasch C. E., Gotschlich E. C. An outer membrane protein of Neisseria meningitidis group B responsible for serotype specificity. J Exp Med. 1974 Jul 1;140(1):87–104. doi: 10.1084/jem.140.1.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Frasch C. E., McNelis R. M., Gotschlich E. C. Strain-specific variation in the protein and lipopolysaccharide composition of the group B meningococcal outer membrane. J Bacteriol. 1976 Aug;127(2):973–981. doi: 10.1128/jb.127.2.973-981.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Gold R., Winklehake J. L., Mars R. S., Artenstein M. S. Identification of an epidemic strain of group C Neisseria meningitidis by bactericidal serotyping. J Infect Dis. 1971 Dec;124(6):593–597. doi: 10.1093/infdis/124.6.593. [DOI] [PubMed] [Google Scholar]
  14. Greenfield S., Feldman H. A. Familial carriers and meningococcal meningitis. N Engl J Med. 1967 Sep 7;277(10):487–502. doi: 10.1056/NEJM196709072771001. [DOI] [PubMed] [Google Scholar]
  15. Greenfield S., Sheehe P. R., Feldman H. A. Meningococcal carriage in a population of "normal" families. J Infect Dis. 1971 Jan;123(1):67–73. doi: 10.1093/infdis/123.1.67. [DOI] [PubMed] [Google Scholar]
  16. Holten E. Serotypes of Neisseria meningitidis isolated from patients in Norway during the first six months of 1978. J Clin Microbiol. 1979 Feb;9(2):186–188. doi: 10.1128/jcm.9.2.186-188.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Marks M. I., Frasch C. E., Shapera R. M. Meningococcal colonization and infection in children and their household contacts. Am J Epidemiol. 1979 May;109(5):563–571. doi: 10.1093/oxfordjournals.aje.a112714. [DOI] [PubMed] [Google Scholar]
  18. Munford R. S., Taunay A. de E., de Morais J. S., Fraser D. W., Feldman R. A. Spread of meningococcal infection within households. Lancet. 1974 Jun 22;1(7869):1275–1278. doi: 10.1016/s0140-6736(74)90022-1. [DOI] [PubMed] [Google Scholar]
  19. Sippel J. E., Girgis N. I. Meningococcal infection in Egypt: laboratory findings in meningitis patients and the prevalence of pharyngeal infection in patients and contacts. Am J Trop Med Hyg. 1978 Sep;27(5):980–985. doi: 10.4269/ajtmh.1978.27.980. [DOI] [PubMed] [Google Scholar]
  20. Zollinger W. D., Mandrell R. E. Outer-membrane protein and lipopolysaccharide serotyping of Neisseria meningitidis by inhibition of a solid-phase radioimmunoassay. Infect Immun. 1977 Nov;18(2):424–433. doi: 10.1128/iai.18.2.424-433.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]

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