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. 1982 Jul;37(1):227–234. doi: 10.1128/iai.37.1.227-234.1982

Serum immunoglobulin A and antibody to M-associated protein in patients with acute glomerulonephritis or rheumatic fever.

E V Potter, M A Shaughnessy, T Poon-King, D P Earle
PMCID: PMC347517  PMID: 7107003

Abstract

Serum immunoglobulin A (IgA) was markedly increased in 80% of 50 patients with acute rheumatic fever in Trinidad in contrast to 20% of 63 patients with acute glomerulonephritis, whereas serum IgG was increased in nearly all of both groups. Since total antibody to M-associated protein (MAP) (assessed by complement fixation) is the only antibody as yet consistently found to be of higher titer in patients with acute rheumatic fever than in patients with acute glomerulonephritis in Trinidad, it was measured and the titers were related to serum levels of IgA. The titers of total antibody to MAP were greater than or equal to 40 in 58% of the rheumatic fever patients, 43% of the nephritis patients, and 8% of well school-children. However, its presence in rheumatic fever patients did not correlate directly with amounts of serum IgA present (r = 0.0507). Moreover, titers of total antibody to MAP related equally well to enzyme-linked immunosorbent assay indicated amounts of IgG antibody (r = 0.3939) and IgA antibody (r = 0.3054) to MAP in rheumatic fever patients but not in nephritis patients (r = 0.0301 for IgA antibody and 0.6909 for IgG antibody to MAP), whereas they related best to IgM antibody to MAP in the school-children (r = 0.4204).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRADSTREET C. M., TAYLOR C. E. Technique of complementfixation test applicable to the diagnosis of virus diseases. Mon Bull Minist Health Public Health Lab Serv. 1962 May;21:96–104. [PubMed] [Google Scholar]
  2. LANCEFIELD R. C., PERLMANN G. E. Preparation and properties of type-specific M antigen isolated from a group A, type 1 hemolytic streptococcus. J Exp Med. 1952 Jul;96(1):71–82. doi: 10.1084/jem.96.1.71. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. POTTER E. V., STOLLERMAN G. H., SIEGEL A. C. Recall of type specific antibodies in man by injections of streptococcal cell walls. J Clin Invest. 1962 Feb;41:301–310. doi: 10.1172/JCI104483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Potter E. V., Svartman M., Burt E. G., Finklea J. F., Poon-King T., Earle D. P. Relationship of acute rheumatic fever to acute glomerulonephritis in Trinidad. J Infect Dis. 1972 Jun;125(6):619–625. doi: 10.1093/infdis/125.6.619. [DOI] [PubMed] [Google Scholar]
  5. Potter E. V., Svartman M., Mohammed I., Cox R., Poon-King T., Earle D. P. Tropical acute rheumatic fever and associated streptococcal infections compared with concurrent acute glomerulonephritis. J Pediatr. 1978 Feb;92(2):325–333. doi: 10.1016/s0022-3476(78)80036-5. [DOI] [PubMed] [Google Scholar]
  6. STOLLERMAN G. H. Factors that predispose to rheumatic fever. Med Clin North Am. 1960 Jan;44:17–28. doi: 10.1016/s0025-7125(16)34052-4. [DOI] [PubMed] [Google Scholar]
  7. Sepulveda R., Longbottom J. L., Pepys J. Enzyme linked immunosorbent assay (ELISA) for IgG and IgE antibodies to protein and polysaccharide antigens of Aspergillus fumigatus. Clin Allergy. 1979 Jul;9(4):359–371. doi: 10.1111/j.1365-2222.1979.tb02494.x. [DOI] [PubMed] [Google Scholar]
  8. Shulman S. T., Ayoub E. M. Qualitative and quantitative aspects of the human antibody response to streptococcal group A carbohydrate. J Clin Invest. 1974 Oct;54(4):990–996. doi: 10.1172/JCI107840. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Svartman M., Potter E. V., Poon-King T., Earle D. P. Salivary immunoglobulins and streptococcal antibodies in patients with acute rheumatic fever. J Lab Clin Med. 1975 Jun;85(6):1013–1021. [PubMed] [Google Scholar]
  10. Voller A., Bidwell D. E., Bartlett A. Enzyme immunoassays in diagnostic medicine. Theory and practice. Bull World Health Organ. 1976;53(1):55–65. [PMC free article] [PubMed] [Google Scholar]
  11. Widdowson J. P., Maxted W. R., Notley C. M., Pinney A. M. The antibody respones in man to infection with different serotypes of group-A streptococci. J Med Microbiol. 1974 Nov;7(4):483–496. doi: 10.1099/00222615-7-4-483. [DOI] [PubMed] [Google Scholar]
  12. Widdowson J. P., Maxted W. R., Pinney A. M. An M-associated protein antigen (MAP) of group A streptococci. J Hyg (Lond) 1971 Dec;69(4):553–564. doi: 10.1017/s0022172400021823. [DOI] [PMC free article] [PubMed] [Google Scholar]

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