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. 1982 Oct;38(1):396–398. doi: 10.1128/iai.38.1.396-398.1982

Retrovirus antigens in brains of mice with scrapie- and murine leukemia virus-induced spongiform encephalopathy.

P M Hoffman, O M Pitts, R G Rohwer, D C Gajdusek, S K Ruscetti
PMCID: PMC347747  PMID: 6292099

Abstract

Wild mouse ecotropic virus-induced spongiform encephalomyelopathy pathologically similar to scrapie was associated with the expression of retrovirus antigens in mouse brains. However, scrapie-infected mice with spongiform encephalopathy showed no increased expression of retrovirus antigens in brain. Thus, the pathogenesis of the scrapie spongiform lesion does not appear to involve activation of endogenous retrovirus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrews J. M., Gardner M. B. Lower motor neuron degeneration associated with type C RNA virus infection in mice: neuropathological features. J Neuropathol Exp Neurol. 1974 Apr;33(2):285–307. doi: 10.1097/00005072-197404000-00007. [DOI] [PubMed] [Google Scholar]
  2. Baringer J. R., Prusiner S. B. Experimental scrapie in mice: ultrastructural observations. Ann Neurol. 1978 Sep;4(3):205–211. doi: 10.1002/ana.410040303. [DOI] [PubMed] [Google Scholar]
  3. Brooks B. R., Swarz J. R., Johnson R. T. Spongiform polioencephalomyelopathy caused by a murine retrovirus. I. Pathogenesis of infection in newborn mice. Lab Invest. 1980 Nov;43(5):480–486. [PubMed] [Google Scholar]
  4. Brooks B. R., Swarz J. R., Narayan O., Johnson R. T. Murine neurotropic retrovirus spongiform polioencephalomyelopathy: acceleration of disease by virus inoculum concentration. Infect Immun. 1979 Feb;23(2):540–544. doi: 10.1128/iai.23.2.540-544.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dickinson A. G. Scrapie in sheep and goats. Front Biol. 1976;44:209–241. [PubMed] [Google Scholar]
  6. Gardner M. B. Type C viruses of wild mice: characterization and natural history of amphotropic, ecotropic, and xenotropic MuLv. Curr Top Microbiol Immunol. 1978;79:215–259. doi: 10.1007/978-3-642-66853-1_5. [DOI] [PubMed] [Google Scholar]
  7. Hampar B., Aaronson S. A., Derge J. G., Chakrabarty M., Showalter S. D., Dunn C. Y. Activation of an endogenous mouse type C virus by ultraviolet-irradiated herpes simplex virus types 1 and 2. Proc Natl Acad Sci U S A. 1976 Feb;73(2):646–650. doi: 10.1073/pnas.73.2.646. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hoffman P. M., Davidson W. F., Ruscetti S. K., Chused T. M., Morse H. C., 3rd Wild mouse ecotropic murine leukemia virus infection of inbred mice: dual-tropic virus expression precedes the onset of paralysis and lymphoma. J Virol. 1981 Aug;39(2):597–602. doi: 10.1128/jvi.39.2.597-602.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hoffman P. M., Ruscetti S. K., Morse H. C., 3rd Pathogenesis of paralysis and lymphoma associated with a wild mouse retrovirus infection. Part 1. Age- and dose-related effects in susceptible laboratory mice. J Neuroimmunol. 1981 Sep;1(3):275–285. doi: 10.1016/0165-5728(81)90031-x. [DOI] [PubMed] [Google Scholar]
  10. Kimberlin R. H. Experimental scrapie in the mouse: a review of an important model disease. Sci Prog. 1976 Winter;63(252):461–481. [PubMed] [Google Scholar]
  11. Kimberlin R. H., Walker C. Characteristics of a short incubation model of scrapie in the golden hamster. J Gen Virol. 1977 Feb;34(2):295–304. doi: 10.1099/0022-1317-34-2-295. [DOI] [PubMed] [Google Scholar]
  12. Lev M., Raine C. S., Levenson S. M. Enhanced survival of germfree mice after infection with irradiated scrapie brain. Experientia. 1971;27(11):1358–1359. doi: 10.1007/BF02136739. [DOI] [PubMed] [Google Scholar]
  13. Marsh R. F., Sipe J. C., Morse S. S., Hanson R. P. Transmissible mink encephalopathy. Reduced spongiform degeneration in aged mink of the Chediak-Higashi genotype. Lab Invest. 1976 Apr;34(4):381–386. [PubMed] [Google Scholar]
  14. McCarter J. A., Ball J. K., Frei J. V. Lower limb paralysis induced in mice by a temperature-sensitive mutant of Moloney leukemia virus. J Natl Cancer Inst. 1977 Jul;59(1):179–183. doi: 10.1093/jnci/59.1.179. [DOI] [PubMed] [Google Scholar]
  15. Morse H. C., 3rd, Chused T. M., Boehm-Truitt M., Mathieson B. J., Sharrow S. O., Hartley J. W. XenCSA: cell surface antigens related to the major glycoproteins (gp70) of xenotropic murine leukemia viruses. J Immunol. 1979 Feb;122(2):443–454. [PubMed] [Google Scholar]
  16. Oldstone M. B., Jensen F., Dixon F. J., Lampert P. W. Pathogenesis of the slow disease of the central nervous system associated with wild mouse virus. II. Role of virus and host gene products. Virology. 1980 Nov;107(1):180–193. doi: 10.1016/0042-6822(80)90283-4. [DOI] [PubMed] [Google Scholar]
  17. Oldstone M. B., Lampert P. W., Lee S., Dixon F. J. Pathogenesis of the slow disease of the central nervous system associated with WM 1504 E virus. I. Relationship of strain susceptibility and replication to disease. Am J Pathol. 1977 Jul;88(1):193–212. [PMC free article] [PubMed] [Google Scholar]
  18. Pease L. R., Abrams G. D., Murphy W. H. FV-1 restriction of age-dependent paralytic lactic dehydrogenase virus infection. Virology. 1982 Feb;117(1):29–37. doi: 10.1016/0042-6822(82)90504-9. [DOI] [PubMed] [Google Scholar]
  19. Pease L. R., Murphy W. H. Co-infection by lactic dehydrogenase virus and C-type retrovirus elicits neurological disease. Nature. 1980 Jul 24;286(5771):398–400. doi: 10.1038/286398a0. [DOI] [PubMed] [Google Scholar]
  20. Ruscetti S. K., Turek L. P., Sherr C. J. Three independent isolates of feline sarcoma virus code for three distinct gag-x polyproteins. J Virol. 1980 Jul;35(1):259–264. doi: 10.1128/jvi.35.1.259-264.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Ruscetti S., Linemeyer D., Field J., Troxler D., Scolnick E. Type-specific radioimmunoassays for the gp70s of mink cell focus-inducing murine leukemia viruses: expression of a cross-reacting antigen in cells infected with the Friend strain of the spleen focus-forming virus. J Exp Med. 1978 Sep 1;148(3):654–663. doi: 10.1084/jem.148.3.654. [DOI] [PMC free article] [PubMed] [Google Scholar]

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