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. 1982 Nov;38(2):548–553. doi: 10.1128/iai.38.2.548-553.1982

Effect of pyridines on phenotypic properties of Bordetella pertussis.

D R Schneider, C D Parker
PMCID: PMC347773  PMID: 6292105

Abstract

Several conditions of growth of Bordetella pertussis cause a reversible phenotypic alteration in properties termed modulation. Growth in medium containing nicotinic acid induces normal (X-mode) cells to change to modulated (C-mode) cells. We examined several pyridines and compounds resembling pyridines for their ability to affect modulation, using envelope protein patterns and serological reactivity as indicators of modulation. We found that 6-chloronicotinic acid and quinaldic acid were more effective modulating stimuli than was nicotinic acid on a molar basis. Both 2-chloronicotinamide and isoniazid interfered with nicotinic acid-induced modulation, and can be called antimodulators. Picolinic acid inhibited growth.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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