Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1982 Nov;38(2):694–698. doi: 10.1128/iai.38.2.694-698.1982

Recovery from T cell depletion during murine listeriosis and effect on a T-dependent antibody response.

Y Y Chan, C Cheers
PMCID: PMC347794  PMID: 6982870

Abstract

During the infection of mice with Listeria monocytogenes, there is a profound depletion of T (Thy-1+ Ig-) lymphocytes between days 1 and 4, followed by an increase in T cells to three times normal levels by day 9. The recovery of T cell numbers required cell proliferation, being sensitive to vinblastin and cyclophosphamide. Adult thymectomy 6 months before infection had no effect on recovery. The repopulating cells were no more sensitive than normal T cells to hydrocortisone. B lymphocytes (Ig+ cells) and null (Thy-1-Ig-) cells increased from day 1 after the injection of either live or (in contrast to T cells) killed Listeria organisms. Their increase was inhibited by vinblastin and cyclophosphamide. Despite T cell depletion, no depression of the antibody response to the T-dependent antigen, sheep erythrocytes, occurred during infection or when spleen cells were adoptively transferred from infected mice to irradiated recipients.

Full text

PDF
694

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Askonas B. A., Corsini A. C., Clayton C. E., Ogilvie B. M. Functional depletion of T- and B-memory cells and other lymphoid cell subpopulations-during trypanosomiasis. Immunology. 1979 Feb;36(2):313–321. [PMC free article] [PubMed] [Google Scholar]
  2. Beller D. I., Kiely J. M., Unanue E. R. Regulation of macrophage populations. I. Preferential induction of Ia-rich peritoneal exudates by immunologic stimuli. J Immunol. 1980 Mar;124(3):1426–1432. [PubMed] [Google Scholar]
  3. Bullock W. E., Jr, Fasal P. Studies of immune mechanisms in leprosy. 3. The role of cellular and humoral factors in impairment of the in vitro immune response. J Immunol. 1971 Apr;106(4):888–899. [PubMed] [Google Scholar]
  4. Bullock W. E., Jr Perturbation of lymphocyte circulation in experimental murine leprosy. I. Description of the defect. J Immunol. 1976 Oct;117(4):1164–1170. [PubMed] [Google Scholar]
  5. Bullock W. E., Jr Perturbation of lymphocyte circulation in experimental murine leprosy. II. Nature of the defect. J Immunol. 1976 Oct;117(4):1171–1178. [PubMed] [Google Scholar]
  6. Chan Y. Y., Cheers C. Mechanism of depletion of T lymphocytes from the spleen of mice infected with Listeria monocytogenes. Infect Immun. 1982 Nov;38(2):686–693. doi: 10.1128/iai.38.2.686-693.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cheers C., McKenzie I. F., Pavlov H., Waid C., York J. Resistance and susceptibility of mice to bacterial infection: course of listeriosis in resistant or susceptible mice. Infect Immun. 1978 Mar;19(3):763–770. doi: 10.1128/iai.19.3.763-770.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cohen J. J., Rodriguez G. E., Kind P. D., Campbell P. A. Listeria cell wall fraction: a B cell mitogen. J Immunol. 1975 Mar;114(3):1132–1134. [PubMed] [Google Scholar]
  9. Cunningham A. J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 1968 Apr;14(4):599–600. [PMC free article] [PubMed] [Google Scholar]
  10. Freeman R. R., Parish C. R. Spleen cell changes during fatal and self-limiting malarial infections of mice. Immunology. 1978 Sep;35(3):479–484. [PMC free article] [PubMed] [Google Scholar]
  11. Kar S. K., Roelants G. E., Mayor-Withey K. S., Pearson T. W. Immunodepression in trypanosome-infected mice. VI. Comparison of immune responses of different lymphoid organs. Eur J Immunol. 1981 Feb;11(2):100–105. doi: 10.1002/eji.1830110207. [DOI] [PubMed] [Google Scholar]
  12. Kearns R. J., Hinrichs D. J. Heat-labile B-cell mitogen obtained from Listeria monocytogenes. Infect Immun. 1978 Dec;22(3):676–680. doi: 10.1128/iai.22.3.676-680.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lane F. C., Unanue E. R. Immunologic events during Listeria monocytogenes infection in mice: adjuvanticity and immunogenicity of macrophage-bound antigens. J Immunol. 1973 Mar;110(3):829–834. [PubMed] [Google Scholar]
  14. Liew F. Y., Dhaliwal S. S., Teh K. L. Dissociative effects of malarial infection on humoral and cell-mediated immunity in mice. Immunology. 1979 May;37(1):35–44. [PMC free article] [PubMed] [Google Scholar]
  15. Lundgren G., Zukoski C. F., Möller G. Differential effects of human granulocytes and lymphocytes on human fibroblasts in vitro. Clin Exp Immunol. 1968 Oct;3(8):817–836. [PMC free article] [PubMed] [Google Scholar]
  16. MILLER J. F. Studies on mouse leukaemia. The role of the thymus in leukaemogenesis by cell-free leukaemic filtrates. Br J Cancer. 1960 Mar;14:93–98. doi: 10.1038/bjc.1960.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Macfarlan R. I., Burns W. H., White D. O. Two cytotoxic cells in peritoneal cavity of virus-infected mice: antibody-dependent macrophages and nonspecific killer cells. J Immunol. 1977 Nov;119(5):1569–1574. [PubMed] [Google Scholar]
  18. Mandel T. E., Cheers C. Resistance and susceptibility of mice to bacterial infection: histopathology of listeriosis in resistant and susceptible strains. Infect Immun. 1980 Dec;30(3):851–861. doi: 10.1128/iai.30.3.851-861.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. McGregor D. D., Logie P. S. The mediator of cellular immunity. VI. Effect of the antimitotic drug vinblastine on the mediator of cellular resistance to infection. J Exp Med. 1973 Mar 1;137(3):660–674. doi: 10.1084/jem.137.3.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. North R. J. Cellular mediators of anti-Listeria immunity as an enlarged population of short lived, replicating T cells. Kinetics of their production. J Exp Med. 1973 Aug 1;138(2):342–355. doi: 10.1084/jem.138.2.342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. North R. J. Suppression of cell-mediated immunity to infection by an antimitotic drug. Further evidence that migrant macrophages express immunity. J Exp Med. 1970 Sep 1;132(3):535–545. doi: 10.1084/jem.132.3.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. North R. J. The action of cortisone acetate on cell-mediated immunity to infection. Suppression of host cell proliferation and alteration of cellular composition of infective foci. J Exp Med. 1971 Dec 1;134(6):1485–1500. doi: 10.1084/jem.134.6.1485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Petit J. C., Unanue E. R. Effects of bacterial products on lymphocytes and macrophages: their possible role in natural resistance to listeria infetion in mice. J Immunol. 1974 Sep;113(3):984–992. [PubMed] [Google Scholar]
  25. Tandon P., Chaturvedi U. C., Mathur A. Differential depletion of T lymphocytes in the spleen of dengue virus-infected mice. Immunology. 1979 May;37(1):1–6. [PMC free article] [PubMed] [Google Scholar]
  26. Zinkernagel R. M., Blanden R. V., Langman R. E. Early appearance of sensitized lymphocytes in mice infected with Listeria monocytogenes. J Immunol. 1974 Feb;112(2):496–501. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES