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. 1982 Dec;38(3):1073–1077. doi: 10.1128/iai.38.3.1073-1077.1982

Relationship between phagocytosis and immunoglobulin A release from human colostral macrophages.

E A Weaver, H Tsuda, R M Goldblum, A S Goldman, C P Davis
PMCID: PMC347859  PMID: 6759405

Abstract

Macrophages and neutrophils that contain mainly secretory immunoglobulin A (IgA) comprise the majority of cells in human colostrum. These cell populations were separated and analyzed for their ability to release total IgA and secretory IgA when stimulated to phagocytose. Colostral macrophages phagocytosed opsonized bacteria and nonopsonized latex particles; at the same time, IgA was released. Neutrophils poorly phagocytosed opsonized bacteria but actively phagocytosed latex particles. In contrast to the macrophages, the neutrophils did not release IgA, even after active phagocytosis of latex. Consequently, colostral macrophages are the main source of IgA released from colostral leukocytes when these cells are exposed to organisms or particles that are phagocytosed. A function for colostral neutrophils which sequester IgA is proposed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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