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. 1982 Dec;38(3):1242–1248. doi: 10.1128/iai.38.3.1242-1248.1982

Mitogenic activity of Sindbis virus and its isolated glycoproteins.

G Goodman-Snitkoff, J J McSharry
PMCID: PMC347881  PMID: 6984018

Abstract

Purified preparations of Sindbis virus, a member of the togavirus family, are mitogenic for lymphocytes from a number of different mouse strains. Cell separation techniques, as well as studies using lymphocytes from the congenitally athymic BALB/c nu/nu mouse, showed that Sindbis virus is a T-cell-independent B-cell mitogen. Additionally, the envelope glycoproteins of Sindbis virus, isolated by Triton X-100 extraction and butanol precipitation, stimulated lymphocytes to incorporate five times as much [3H]thymidine into their DNA as did the Sindbis virion. These results are similar to those previously reported for vesicular stomatitis virus and herpes simplex virus types I and II and for the purified glycoproteins of vesicular stomatitis virus and influenza virus.

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Selected References

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