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. 1982 Dec;38(3):1279–1284. doi: 10.1128/iai.38.3.1279-1284.1982

Inhibition of zymosan-induced alternative complement pathway activation by concanavalin A.

M C Smith, J Pensky, G B Naff
PMCID: PMC347886  PMID: 6924928

Abstract

Zymosan, a polysaccharide composed primarily of glucan and mannan residues, activates the complement system through the alternative complement pathway. We showed that zymosan-induced complement activation is inhibited by zymosan-bound lectins with carbohydrate specificities for mannosyl and glycosyl residues. Lectins unable to bind mannosyl or glucosyl residues did not inhibit zymosan-induced complement activation.

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Selected References

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