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. 1980 Jan;77(1):658–661. doi: 10.1073/pnas.77.1.658

Interplexiform cell in cat retina: identification by uptake of gamma-[3H]aminobutyric acid and serial reconstruction.

Y Nakamura, B A McGuire, P Sterling
PMCID: PMC348334  PMID: 6928650

Abstract

After intravitreal injection of gamma-[3H] aminobutyric acid (GAB), 2% of the neurons at the outer margin of the inner plexiform layer were intensely labeled. Reconstructions of these neurons from serial electron microscope autoradiograms showed that they are interplexiform cells, which synapse on bipolar processes in the outer plexiform layer and on amacrine and bipolar processes in the inner plexiform layer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boycott B. B., Dowling J. E., Fisher S. K., Kolb H., Laties A. M. Interplexiform cells of the mammalian retina and their comparison with catecholamine-containing retinal cells. Proc R Soc Lond B Biol Sci. 1975 Dec 2;191(1104):353–368. doi: 10.1098/rspb.1975.0133. [DOI] [PubMed] [Google Scholar]
  2. Boycott B. B., Kolb H. The connections between bipolar cells and photoreceptors in the retina of the domestic cat. J Comp Neurol. 1973 Mar 1;148(1):91–114. doi: 10.1002/cne.901480106. [DOI] [PubMed] [Google Scholar]
  3. Brandon C., Lam D. M., Wu J. Y. The gamma-aminobutyric acid system in rabbit retina: localization by immunocytochemistry and autoradiography. Proc Natl Acad Sci U S A. 1979 Jul;76(7):3557–3561. doi: 10.1073/pnas.76.7.3557. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bruun A., Ehinger B. Uptake of certain possible neurotransmitters into retinal neurons of some mammals. Exp Eye Res. 1974 Nov;19(5):435–447. doi: 10.1016/0014-4835(74)90052-9. [DOI] [PubMed] [Google Scholar]
  5. Caldwell J. H., Daw N. W., Wyatt H. J. Effects of picrotoxin and strychnine on rabbit retinal ganglion cells: lateral interactions for cells with more complex receptive fields. J Physiol. 1978 Mar;276:277–298. doi: 10.1113/jphysiol.1978.sp012233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Chan-Palay V., Palay S. L. Ultrastructural localization of gamma-aminobutyric acid receptors in the mammalian central nervous system by means of [3H]muscimol binding. Proc Natl Acad Sci U S A. 1978 Jun;75(6):2977–2980. doi: 10.1073/pnas.75.6.2977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Davis T. L., Spencer R. F., Sterling P. Preparing autoradiograms of serial sections for electron microscopy. J Neurosci Methods. 1979 Aug;1(2):179–183. doi: 10.1016/0165-0270(79)90015-3. [DOI] [PubMed] [Google Scholar]
  8. Dowling J. E., Ehinger B. Synaptic organization of the amine-containing interplexiform cells of the goldfish and Cebus monkey retinas. Science. 1975 Apr 18;188(4185):270–273. doi: 10.1126/science.804181. [DOI] [PubMed] [Google Scholar]
  9. Dowling J. E., Ehinger B. The interplexiform cell system. I. Synapses of the dopaminergic neurons of the goldfish retina. Proc R Soc Lond B Biol Sci. 1978 Apr 13;201(1142):7–26. doi: 10.1098/rspb.1978.0030. [DOI] [PubMed] [Google Scholar]
  10. Gallego A. Horizontal and amacrine cells in the mammal's retina. Vision Res. 1971;Suppl 3:33–50. doi: 10.1016/0042-6989(71)90029-0. [DOI] [PubMed] [Google Scholar]
  11. Graham L. T. Intraretinal distribution of GABA content and GAD activity. Brain Res. 1972 Jan 28;36(2):476–479. doi: 10.1016/0006-8993(72)90759-7. [DOI] [PubMed] [Google Scholar]
  12. Hedden W. L., Jr, Dowling J. E. The interplexiform cell system. II. Effects of dopamine on goldfish retinal neurones. Proc R Soc Lond B Biol Sci. 1978 Apr 13;201(1142):27–55. doi: 10.1098/rspb.1978.0031. [DOI] [PubMed] [Google Scholar]
  13. Hökfelt T., Ljungdahl A. Autoradiographic identification of cerebral and cerebellar cortical neurons accumulating labeled gamma-aminobutyric acid ( 3 H-GABA). Exp Brain Res. 1972;14(4):354–362. doi: 10.1007/BF00235032. [DOI] [PubMed] [Google Scholar]
  14. Kirby A. W., Enroth-Cugell C. The involvement of gamma-aminobutyric acid in the organization of cat retinal ganglion cell receptive fields. A study with picrotoxin and bicuculline. J Gen Physiol. 1976 Oct;68(4):465–484. doi: 10.1085/jgp.68.4.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kolb H., West R. W. Synaptic connections of the interplexiform cell in the retina of the cat. J Neurocytol. 1977 Apr;6(2):155–170. doi: 10.1007/BF01261503. [DOI] [PubMed] [Google Scholar]
  16. Kramer S. G. Dopamine: A retinal neurotransmitter. I. Retinal uptake, storage, and light-stimulated release of H3-dopamine in vivo. Invest Ophthalmol. 1971 Jun;10(6):438–452. [PubMed] [Google Scholar]
  17. Kramer S. G., Potts A. M., Mangnall Y. Dopamine: a retinal neurotransmitter. II. Autoradiographic localization of H3-dopamine in the retina. Invest Ophthalmol. 1971 Aug;10(8):617–624. [PubMed] [Google Scholar]
  18. Miller R. F., Dacheux R. F., Frumkes T. E. Amacrine cells in Necturus retina: evidence for independent gamma-aminobutyric acid- and glycine-releasing neurons. Science. 1977 Nov 18;198(4318):748–750. doi: 10.1126/science.910159. [DOI] [PubMed] [Google Scholar]
  19. Wässle H., Riemann H. J. The mosaic of nerve cells in the mammalian retina. Proc R Soc Lond B Biol Sci. 1978 Mar 22;200(1141):441–461. doi: 10.1098/rspb.1978.0026. [DOI] [PubMed] [Google Scholar]

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