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. 1980 Mar;77(3):1471–1475. doi: 10.1073/pnas.77.3.1471

Role of G0-G1 arrest in the inhibition of tumor cell growth by interferon.

A A Creasey, J C Bartholomew, T C Merigan
PMCID: PMC348517  PMID: 6154934

Abstract

We report here that human leukocyte interferon preparations are capable of influencing the transition of human melanoma cells from the "A" state to the "B" phase. Human melanoma cells that enter a quiescent stage at high cell density are more sensitive to the cytostatic action of interferon than those that continue to proliferate under similar conditions. Cell cycle perturbations caused by interferon in these cells include a decreased transition rate out of G0-G1 ("A" state) into S ("B" phase) and a prolongation of S. These findings support the idea that some metabolic event is required for progress through the G0-G1 phase of the cell cycle and is susceptible to interferon action.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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