Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1981 Sep;78(9):5890–5894. doi: 10.1073/pnas.78.9.5890

D-aspartate potentiates the effects of L-glutamate on horizontal cells in goldfish retina.

A T Ishida, G L Fain
PMCID: PMC348898  PMID: 6117861

Abstract

The amino acids L-glutamate and L-aspartate depolarize H1 horizontal cells in the perfused goldfish retina but only at millimolar concentrations. The effects of L-glutamate (but not of L-aspartate) are potentiated approximately 15-fold by exposure to D-aspartate. D-Aspartate blocks acidic amino acid uptake in goldfish retina, so that the potentiation of L-glutamate may be produced by an increase in its effective concentration at the horizontal cell membrane. Because D-aspartate also augments the light responses of horizontal cells, our results are consistent with the possibility that L-glutamate is a neurotransmitter of cone photoreceptors in goldfish.

Full text

PDF
5893

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Balcar V. J., Johnston G. A. The structural specificity of the high affinity uptake of L-glutamate and L-aspartate by rat brain slices. J Neurochem. 1972 Nov;19(11):2657–2666. doi: 10.1111/j.1471-4159.1972.tb01325.x. [DOI] [PubMed] [Google Scholar]
  2. CURTIS D. R., PHILLIS J. W., WATKINS J. C. The chemical excitation of spinal neurones by certain acidic amino acids. J Physiol. 1960 Mar;150:656–682. doi: 10.1113/jphysiol.1960.sp006410. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cervetto L., MacNichol E. F., Jr Inactivation of horizontal cells in turtle retina by glutamate and aspartate. Science. 1972 Nov 17;178(4062):767–768. doi: 10.1126/science.178.4062.767. [DOI] [PubMed] [Google Scholar]
  4. Dowling J. E., Ripps H. Adaptation in skate photoreceptors. J Gen Physiol. 1972 Dec;60(6):698–719. doi: 10.1085/jgp.60.6.698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ehinger B., Falck B. Autoradiography of some suspected neurotransmitter substances: GABA glycine, glutamic acid, histamine, dopamine, and L-dopa. Brain Res. 1971 Oct 8;33(1):157–172. doi: 10.1016/0006-8993(71)90314-3. [DOI] [PubMed] [Google Scholar]
  6. Fagg G. E., Lane J. D. The uptake and release of putative amino acid neurotransmitters. Neuroscience. 1979;4(8):1015–1036. doi: 10.1016/0306-4522(79)90185-4. [DOI] [PubMed] [Google Scholar]
  7. Hashimoto Y., Kato A., Inokuchi M., Watanabe K. Re-examination of horizontal cells in the carp retina with procion yellow electrode. Vision Res. 1976 Jan;16(1):25–29. doi: 10.1016/0042-6989(76)90072-9. [DOI] [PubMed] [Google Scholar]
  8. Hertz L. Functional interactions between neurons and astrocytes I. Turnover and metabolism of putative amino acid transmitters. Prog Neurobiol. 1979;13(3):277–323. doi: 10.1016/0301-0082(79)90018-2. [DOI] [PubMed] [Google Scholar]
  9. Johnson J. L. The excitant amino acids glutamic and aspartic acid as transmitter candidates in the vertebrate central nervous system. Prog Neurobiol. 1978;10(3):155–202. doi: 10.1016/0301-0082(78)90002-3. [DOI] [PubMed] [Google Scholar]
  10. KRNJEVIC K., PHILLIS J. W. Iontophoretic studies of neurones in the mammalian cerebral cortex. J Physiol. 1963 Feb;165:274–304. doi: 10.1113/jphysiol.1963.sp007057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kaneko A. Physiological and morphological identification of horizontal, bipolar and amacrine cells in goldfish retina. J Physiol. 1970 May;207(3):623–633. doi: 10.1113/jphysiol.1970.sp009084. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kaneko A., Shimazaki H. Synaptic transmission from photoreceptors to bipolar and horizontal cells in the carp retina. Cold Spring Harb Symp Quant Biol. 1976;40:537–546. doi: 10.1101/sqb.1976.040.01.050. [DOI] [PubMed] [Google Scholar]
  13. Murakami M., Otsu K., Otsuka T. Effects of chemicals on receptors and horizontal cells in the retina. J Physiol. 1972 Dec;227(3):899–913. doi: 10.1113/jphysiol.1972.sp010065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Stell W. K., Lightfoot D. O. Color-specific interconnections of cones and horizontal cells in the retina of the goldfish. J Comp Neurol. 1975 Feb 15;159(4):473–502. doi: 10.1002/cne.901590404. [DOI] [PubMed] [Google Scholar]
  15. White R. D., Neal M. J. The uptake of L-glutamate by the retina. Brain Res. 1976 Jul 23;111(1):79–93. doi: 10.1016/0006-8993(76)91050-7. [DOI] [PubMed] [Google Scholar]
  16. Wu S. M., Dowling J. E. L-aspartate: evidence for a role in cone photoreceptor synaptic transmission in the carp retina. Proc Natl Acad Sci U S A. 1978 Oct;75(10):5205–5209. doi: 10.1073/pnas.75.10.5205. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES