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. 1981 Sep;78(9):5895–5898. doi: 10.1073/pnas.78.9.5895

Biological importance of the retrograde axonal transport of nerve growth factor in sensory neurons.

M Goedert, K Stoeckel, U Otten
PMCID: PMC348900  PMID: 6170988

Abstract

Nerve growth factor is retrogradely transported in sympathetic and sensory neurons throughout life. Although this transport is known to be biologically significant in sympathetic neurons, such a function was not yet known in sensory ganglia. By using the neuropeptide substance P as a biochemical marker, we show that sensory ganglia from newborn and adult rats respond in nerve growth factor and that its retrograde axonal transport is biologically relevant, as indicated by an increase in substance P and in general protein content.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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