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. 1981 Oct;78(10):6281–6285. doi: 10.1073/pnas.78.10.6281

Interferon increases the abundance of submembranous microfilaments in HeLa-S3 cells in suspension culture.

E Wang, L M Pfeffer, I Tamm
PMCID: PMC349022  PMID: 6171815

Abstract

Human beta (fibroblast) interferon inhibits the proliferation of human HeLa-S3 carcinoma cells in suspension culture. Accompanying this effect, the lateral mobility of cell surface receptors for concanavalin A is decreased and the rigidity of the plasma membrane lipid bilayer is increased. The present findings show a marked increase in the number of polymerized actin-containing microfilaments 3 days after treatment of HeLa-S3 cells with beta-interferon (640 units/ml). The cortical region of the treated enlarged cells contains a thick and dense meshwork of 40-70 A microfilaments. The actin nature of the filaments was verified by their ability to bind heavy meromyosin. These results support the concept that beta-interferon induces a coordinated response in the plasma membrane and the underlying microfilaments in both tumor and normal cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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