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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1980 Jun;77(6):3135–3138. doi: 10.1073/pnas.77.6.3135

Sequential medical trials

T L Lai †, Bruce Levin †, Herbert Robbins †, David Siegmund ‡
PMCID: PMC349568  PMID: 16592839

Abstract

A model for sequential clinical trials is discussed. Three proposed stopping rules are studied by the Monte Carlo method for small patient horizons and mathematically for large patient horizons. They are shown to be about equally effective and asymptotically optimal from both Bayesian and frequentist points of view and are markedly superior to any fixed sample size procedure.

Keywords: stopping rules, asymptotic optimality

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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