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. 1980 Jul;77(7):3841–3844. doi: 10.1073/pnas.77.7.3841

Calmodulin activates prokaryotic adenylate cyclase.

J Wolff, G H Cook, A R Goldhammer, S A Berkowitz
PMCID: PMC349722  PMID: 6253992

Abstract

The adenylate cyclase of Bordetella pertussis is stimulated 100- to 1000-fold in a dose-dependent manner by calf brain calmodulin. The system has the following properties. (i) The activation is prevented by ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid and restored by Ca2+. (ii) Oxidation of the methionine residues of calmodulin abolishes the ability to activate the cyclase. (iii) Trifluoperazine inhibits calmodulin-activated cyclase. (iv) A troponin C preparation stimulates the B. pertussis cyclase with < 0.01 the potency of calmodulin. Although calmodulin has not been demonstrated in prokaryotes, this is an example of a (eukaryotic) calmodulin effect in a prokaryote.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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