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. 1980 Aug;77(8):4417–4419. doi: 10.1073/pnas.77.8.4417

Uptake of free choline by isolated perfused rat liver.

S H Zeisel, D L Story, R J Wurtman, H Brunengraber
PMCID: PMC349854  PMID: 6933493

Abstract

The uptake of free choline by isolated perfused rat liver was characterized. A saturable uptake mechanism [Ka = 0.17 +/- 0.07 mM (SD); Vmax = 0.84 +/- 0.16 mumol/min X g dry weight] and a nonsaturable mechanism (through which uptake is proportional to choline concentration in the perfusate) were identified. Most of the choline transported into hepatocytes was converted to betaine, phosphorylcholine, or lecithin. Free choline also accumulated within the intracellular space, suggesting that choline oxidase activity does not always limit choline's uptake by the liver.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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