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. 1980 Aug;77(8):5021–5024. doi: 10.1073/pnas.77.8.5021

Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes.

D Pearson, J E Shively, B R Clark, I I Geschwind, M Barkley, R S Nishioka, H A Bern
PMCID: PMC349982  PMID: 6107911

Abstract

Urotensin II, a peptide hormone from the caudal neurosecretory system of the teleost, Gillichthys mirabilis, was isolated by using classical chromatographic techniques and high-performance liquid chromatography (HPLC). Direct microtechniques for sequence determination were used to establish its structure. Urotensin II from Gillichthys is a 1363-dalton dodecapeptide with the amino acid sequence Ala-Gly-Thr-Ala-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val. This sequence is homologous with somatostatin in positions 1 and 2 and 7-9. The sequence has been verified by the production of a bioactive synthetic urotensin II. The possible chemical and physiological significance of its homology to somatostatin is discussed.

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Selected References

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