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. 1980 Sep;77(9):5419–5423. doi: 10.1073/pnas.77.9.5419

Selective killing of normal or neoplastic B cells by antibodies coupled to the A chain of ricin.

K A Krolick, C Villemez, P Isakson, J W Uhr, E S Vitetta
PMCID: PMC350070  PMID: 6968912

Abstract

Highly specific antibodies (affinity-purified or hybridoma) directed against cell surface immunoglobulins on normal or neoplastic murine B lymphocytes were covalently coupled to the A chain of the plant toxin ricin. Such conjugates containing antibodies specific for IgM, for either of the two allotypes of IgD, or for the idiotype of the B cell tumor BCL1 rapidly bound in vitro to cells expressing the corresponding surface antigen and inhibited protein synthesis in such cells. The results demonstrate that A chain-coupled anti-idiotype antibody may be useful as a tumor-specific cytotoxic agent.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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