Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1980 Sep;77(9):5515–5519. doi: 10.1073/pnas.77.9.5515

Brain regulation of gastric secretion: influence of neuropeptides.

Y Taché, W Vale, J Rivier, M Brown
PMCID: PMC350092  PMID: 6159649

Abstract

Several neuropeptides injected intracisternally were assessed for their effects on gastric secretion in rats. Bombesin (1 microgram) completely suppressed gastric acid secretion, produced the volume of gastric secretion, and partially blocked insulin- or 2-deoxy-D-glucose-induced stimulation of gastric acid output. The inhibitory effect of this peptide is dose-dependent, long-acting, reversible, and specific. Bombesin response appears to be central nervous system-mediated; its expression is not dependent on the vagus nerve or the adrenal glands, and does not rely on a decrease in gastrin secretion. Among seven other peptides tested, only beta-endorphin and a potent gonadotropin releasing-factor (gonadoliberin) agonist significantly reduced gastric acid secretion, with an activity ca. 100 times less than that of bombesin. The presence of bombesin-like material in rat brain and the high potency of bombesin to inhibit gastric secretion suggest that this peptide may be of physiologic significance as a chemical messenger involved in brain modulation of gastric secretion.

Full text

PDF
5516

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anastasi A., Erspamer V., Bucci M. Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes. Experientia. 1971 Feb 15;27(2):166–167. doi: 10.1007/BF02145873. [DOI] [PubMed] [Google Scholar]
  2. Basso N., Lezoche E., Giri S., Percoco M., Speranza V. Acid and gastrin levels after bombesin and calcium infusion in patients with incomplete antrectomy. Am J Dig Dis. 1977 Feb;22(2):125–128. doi: 10.1007/BF01072954. [DOI] [PubMed] [Google Scholar]
  3. Bertaccini G., Erspamer V., Impicciatore M. The actions of bombesin on gastric secretion of the dog and the rat. Br J Pharmacol. 1973 Nov;49(3):437–444. doi: 10.1111/j.1476-5381.1973.tb17254.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brodie D. A., Lotti V. J., Bauer B. G. Drug effects on gastric secretion and stress gastric hemorrhage in the rat. Am J Dig Dis. 1970 Feb;15(2):111–120. doi: 10.1007/BF02235639. [DOI] [PubMed] [Google Scholar]
  5. Brodie D. A. The mechanism of gastric hyperacidity produced by pylorus ligation in the rat. Am J Dig Dis. 1966 Mar;11(3):231–241. doi: 10.1007/BF02233904. [DOI] [PubMed] [Google Scholar]
  6. Brown M. R., Rivier J., Vale W. W. Bombesin affects the central nervous system to produce hyperglycemia in rats. Life Sci. 1977 Dec 15;21(12):1729–1734. doi: 10.1016/0024-3205(77)90151-5. [DOI] [PubMed] [Google Scholar]
  7. Brown M., Märki W., Rivier J. Is gastrin releasing peptide mammalian bombesin? Life Sci. 1980 Jul 14;27(2):125–128. doi: 10.1016/0024-3205(80)90453-1. [DOI] [PubMed] [Google Scholar]
  8. Brown M., Rivier J., Vale W. Bombesin:potent effects on thermoregulation in the rat. Science. 1977 May 27;196(4293):998–1000. doi: 10.1126/science.860130. [DOI] [PubMed] [Google Scholar]
  9. Brown M., Tache Y., Fisher D. Central nervous system action of bombesin: mechanism to induce hyperglycemia. Endocrinology. 1979 Sep;105(3):660–665. doi: 10.1210/endo-105-3-660. [DOI] [PubMed] [Google Scholar]
  10. Christiansen J., Holst J. J., Kalaja E. Inhibition of gastric acid secretion in man by exogenous and endogenous pancreatic glucagon. Gastroenterology. 1976 May;70(5 PT1):688–692. [PubMed] [Google Scholar]
  11. Colin-Jones D. G., Himsworth R. L. The location of the chemoreceptor controlling gastric acid secretion during hypoglycaemia. J Physiol. 1970 Feb;206(2):397–409. doi: 10.1113/jphysiol.1970.sp009020. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hirschowitz B. I., Gibson R. G. Stimulation of gastrin release and gastric secretion: effect of bombesin and a nonapeptide in fistula dogs with and without fundic vagotomy. Digestion. 1978;18(3-4):227–239. doi: 10.1159/000198206. [DOI] [PubMed] [Google Scholar]
  13. Hirschowitz B. I., Sachs G. Vagal gastric secretory stimulation by 2-deoxy-D-glucose. Am J Physiol. 1965 Sep;209(3):452–460. doi: 10.1152/ajplegacy.1965.209.3.452. [DOI] [PubMed] [Google Scholar]
  14. Jan Y. N., Jan L. Y., Kuffler S. W. A peptide as a possible transmitter in sympathetic ganglia of the frog. Proc Natl Acad Sci U S A. 1979 Mar;76(3):1501–1505. doi: 10.1073/pnas.76.3.1501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Lin T. M., Warrick M. W. Action of acetylsalicylic acid and glucagon on acid secretion mucosal blood flow, bleeding and net ionic efflux in the fundic pouch of pentagastrin-stimulated dogs. Arch Int Pharmacodyn Ther. 1974 Aug;210(2):279–287. [PubMed] [Google Scholar]
  16. McDonald T. J., Jörnvall H., Nilsson G., Vagne M., Ghatei M., Bloom S. R., Mutt V. Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue. Biochem Biophys Res Commun. 1979 Sep 12;90(1):227–233. doi: 10.1016/0006-291x(79)91614-0. [DOI] [PubMed] [Google Scholar]
  17. Misher A., Brooks F. P. Electrical stimulation of hypothalamus and gastric secretion in the albino rat. Am J Physiol. 1966 Aug;211(2):403–406. doi: 10.1152/ajplegacy.1966.211.2.403. [DOI] [PubMed] [Google Scholar]
  18. Moody T. W., Pert C. B., Rivier J., Brown M. R. Bomebesin: specific binding to rat brain membranes. Proc Natl Acad Sci U S A. 1978 Nov;75(11):5372–5376. doi: 10.1073/pnas.75.11.5372. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Moore J. G. Gastric acid suppression by intravenous glucose solutions. Gastroenterology. 1973 Jun;64(6):1106–1110. [PubMed] [Google Scholar]
  20. Nemeroff C. B., Osbahr A. J., 3rd, Manberg P. J., Ervin G. N., Prange A. J., Jr Alterations in nociception and body temperature after intracisternal administration of neurotensin, beta-endorphin, other endogenous peptides, and morphine. Proc Natl Acad Sci U S A. 1979 Oct;76(10):5368–5371. doi: 10.1073/pnas.76.10.5368. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Osumi Y., Aibara S., Sakae K., Fujiwara M. Central noradrenergic inhibition of gastric mucosal blood flow and acid secretion in rats. Life Sci. 1977 Apr 15;20(8):1407–1416. doi: 10.1016/0024-3205(77)90369-1. [DOI] [PubMed] [Google Scholar]
  22. Osumi Y., Nagasaka Y., Wang, Fu L. H., Fujiwara M. Inhibition of gastric acid secretion and mucosal blood flow induced by intraventricularly applied neurotensin in rats. Life Sci. 1978 Dec 4;23(23):2275–2280. doi: 10.1016/0024-3205(78)90192-3. [DOI] [PubMed] [Google Scholar]
  23. Pittman Q. J., Taché Y., Brown M. R. Bombesin acts in preoptic area to produce hypothermia in rats. Life Sci. 1980 Mar 3;26(9):725–730. doi: 10.1016/0024-3205(80)90262-3. [DOI] [PubMed] [Google Scholar]
  24. RIDLEY P. T., BROOKS F. P. ALTERATIONS IN GASTRIC SECRETION FOLLOWING HYPOTHALAMIC LESIONS PRODUCING HYPERPHAGIA. Am J Physiol. 1965 Aug;209:319–323. doi: 10.1152/ajplegacy.1965.209.2.319. [DOI] [PubMed] [Google Scholar]
  25. Rivier J. E. Somatostatin. Total solid phase synthesis. J Am Chem Soc. 1974 May 1;96(9):2986–2992. doi: 10.1021/ja00816a053. [DOI] [PubMed] [Google Scholar]
  26. Soll A. H., Walsh J. H. Regulation of gastric acid secretion. Annu Rev Physiol. 1979;41:35–53. doi: 10.1146/annurev.ph.41.030179.000343. [DOI] [PubMed] [Google Scholar]
  27. Stacher G., Bauer P., Schulze D., Pointner H., Landgraf M. Effect of alterations of blood glucose levels on gastric acid secretion, plasma gastrin, and plasma osmolality in man. Am J Dig Dis. 1976 Jul;21(7):563–568. doi: 10.1007/BF01464764. [DOI] [PubMed] [Google Scholar]
  28. Taché Y., Brown M., Collu R. Effects of neuropeptides on adenohypophyseal hormone response to acute stress in male rats. Endocrinology. 1979 Jul;105(1):220–224. doi: 10.1210/endo-105-1-220. [DOI] [PubMed] [Google Scholar]
  29. Taché Y., Pittman Q., Brown M. Bombesin-induced poikilothermy in rats. Brain Res. 1980 Apr 28;188(2):525–530. doi: 10.1016/0006-8993(80)90050-5. [DOI] [PubMed] [Google Scholar]
  30. Taché Y., Simard P., Collu R. Prevention by bombesin of cold-restraint stress induced hemorrhagic lesions in rats. Life Sci. 1979 Apr 30;24(18):1719–1725. doi: 10.1016/0024-3205(79)90258-3. [DOI] [PubMed] [Google Scholar]
  31. Villarreal J. A., Brown M. R. Bombesin-like peptide in hypothalamus: chemical and immunological characterization. Life Sci. 1978 Dec 31;23(27-28):2729–2733. doi: 10.1016/0024-3205(78)90653-7. [DOI] [PubMed] [Google Scholar]
  32. Yamaguchi I., Hiroi J., Kumada S. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203(1):125–131. [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES