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. 1981 Jul;33(1):34–42. doi: 10.1128/iai.33.1.34-42.1981

Cellular and humoral immunity in subacute sclerosing panencephalitis.

S S Dhib-Jalbut, A M Abdelnoor, F S Haddad
PMCID: PMC350649  PMID: 6973545

Abstract

Cellular and humoral immunity was studied in 26 patients with subacute sclerosing panencephalitis. Results were compared with those of 14 normal controls and 11 patients suffering from other neurological disorders. It was shown that cellular and humoral immune responses are adequate in subacute sclerosing panencephalitis. The persistently elevated levels of serum immunoglobulin G (IgG) and IgA indicated a persistent infection, and their progressive rise in later stages correlated with the progressive nature of the illness. IgG progressively increased with the clinical stage in the cerebrospinal fluid unaccompanied by a corresponding rise in the measles antibody titer. This suggests that antigenic determinants other than those tested play a role in the production of IgG in the cerebrospinal fluid. The progressive increase in the ratio of cerebrospinal fluid to serum IgG with the advance of the disease suggests synthesis of IgG locally in the central nervous system. Elevated measles antibody titer in serum and cerebrospinal fluid is a consistent aid in the diagnosis of subacute sclerosing panencephalitis. It is more specific in cerebrospinal fluid than in serum. Its level did not vary significantly with the clinical stages or duration of illness. Depressed serum complement activity has been detected in some subacute sclerosing panencephalitis patients in whom serum levels of the third and fourth components of the complement were normal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahmed A., Strong D. M., Sell K. W., Thurman G. B., Knudsen R. C., Wistar R., Jr, Grace W. R. Demonstration of a blocking factor in the plasma and spinal fluid of patients with subacute sclerosing panencephalitis. I. Partial characterization. J Exp Med. 1974 Apr 1;139(4):902–924. doi: 10.1084/jem.139.4.902. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Alami S. Y., Zurayk H. C., Farah F. S. Serum immunoglobulin levels in normal children and adults in the Lebanese and other Arab Middle Eastern populations. J Med Liban. 1980;31(1):43–58. [PubMed] [Google Scholar]
  3. Barbanti-Brodano G., Oyanagi S., Katz M., Koprowski H. Presence of 2 different viral agents in brain cells of patients with subacute sclerosing panencephalitis. Proc Soc Exp Biol Med. 1970 May;134(1):230–236. doi: 10.3181/00379727-134-34765. [DOI] [PubMed] [Google Scholar]
  4. Connolly J. H., Allen I. V., Hurwitz L. J., Millar J. H. Measles-virus antibody and antigen in subacute sclerosing panencephalitis. Lancet. 1967 Mar 11;1(7489):542–544. doi: 10.1016/s0140-6736(67)92117-4. [DOI] [PubMed] [Google Scholar]
  5. Cutler R. W., Merler E., Hammerstad J. P. Production of antibody by the central nervous system in subacute sclerosing panencephalitis. Neurology. 1968 Jan;18(1 Pt 2):129–132. doi: 10.1212/wnl.18.1_part_2.129. [DOI] [PubMed] [Google Scholar]
  6. Ewan P. W., Lachmann P. J. IgG synthesis within the brain in multiple sclerosis and subacute sclerosing panencephalitis. Clin Exp Immunol. 1979 Feb;35(2):227–235. [PMC free article] [PubMed] [Google Scholar]
  7. Freeman J. M., Magoffin R. L., Lennette E. H., Herndon R. M. Additional evidence of the relation between subacute inclusion-body encephalitis and measles virus. Lancet. 1967 Jul 15;2(7507):129–131. doi: 10.1016/s0140-6736(67)92965-0. [DOI] [PubMed] [Google Scholar]
  8. Gerson K. L., Haslam R. H. Subtle immunologic abnormalities in four boys with subacute sclerosing panencephalitis. N Engl J Med. 1971 Jul 8;285(2):78–82. doi: 10.1056/NEJM197107082850203. [DOI] [PubMed] [Google Scholar]
  9. Haddad F. S., Risk W. S., Jabbour J. T. Subacute sclerosing panencephalitis in the Middle East: report of 99 cases. Ann Neurol. 1977 Mar;1(3):211–217. doi: 10.1002/ana.410010303. [DOI] [PubMed] [Google Scholar]
  10. Horta-Barbosa L., Fuccillo D. A., London W. T., Jabbour J. T., Zeman W., Sever J. L. Isolation of measles virus from brain cell cultures of two patients with subacute sclerosing panencephalitis. Proc Soc Exp Biol Med. 1969 Oct;132(1):272–277. doi: 10.3181/00379727-132-34196. [DOI] [PubMed] [Google Scholar]
  11. Horta-Barbosa L., Krebs H., Ley A., Chen T. C., Gilkeson M. R., Sever J. L. Progressive increase in cerebrospinal fluid measles antibody levels in subacute sclerosing panencephalitis. Pediatrics. 1971 Apr;47(4):782–783. [PubMed] [Google Scholar]
  12. Jabbour J. T., Roane J. A., Sever J. L. Studies of delayed dermal hypersensitivity in patients with subacute sclerosing panencephalitis. Neurology. 1969 Oct;19(10):929–931. doi: 10.1212/wnl.19.10.929. [DOI] [PubMed] [Google Scholar]
  13. Klajman A., Sternbach M., Ranon L., Drucker M., Geminder D., Sadan N. Impaired delayed hypersensitivity in subacute sclerosing panencephalitis. Acta Paediatr Scand. 1973 Sep;62(5):523–526. doi: 10.1111/j.1651-2227.1973.tb08150.x. [DOI] [PubMed] [Google Scholar]
  14. Kolar O. Immunopathologic observations in subacute sclerosing panencephalitis. Neurology. 1968 Jan;18(1 Pt 2):107–111. doi: 10.1212/wnl.18.1_part_2.107. [DOI] [PubMed] [Google Scholar]
  15. Kreth W. H., Käckell M. Y., ter Meulen V. Demonstration of in vitro lymphocyte-mediated cytotoxicity against measles virus in SSPE. J Immunol. 1975 Mar;114(3):1042–1046. [PubMed] [Google Scholar]
  16. Legg N. J. Virus antibodies in subacute sclerosing panencephalitis: a study of 22 patients. Br Med J. 1967 Aug 5;3(5561):350–352. doi: 10.1136/bmj.3.5561.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  18. Moulias R. L., Reinert P., Goust J. M. Immunologic abnormalities in subacute sclerosing panencephalitis. N Engl J Med. 1971 Nov 4;285(19):1090–1090. [PubMed] [Google Scholar]
  19. NORRBY E. Hemagglutination by measles virus. 4. A simple procedure for production of high potency antigen for hemagglutination-inhibition (HI) tests. Proc Soc Exp Biol Med. 1962 Dec;111:814–818. doi: 10.3181/00379727-111-27930. [DOI] [PubMed] [Google Scholar]
  20. Payne F. E., Baublis J. V. Decreased reactivity of SSPE strains of measles virus with antibody. J Infect Dis. 1973 May;127(5):505–511. doi: 10.1093/infdis/127.5.505. [DOI] [PubMed] [Google Scholar]
  21. Payne F. E., Baublis J. V., Itabashi H. H. Isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panencephalitis. N Engl J Med. 1969 Sep 11;281(11):585–589. doi: 10.1056/NEJM196909112811103. [DOI] [PubMed] [Google Scholar]
  22. Risk W. S., Haddad F. S. The variable natural history of subacute sclerosing panencephalitis: a study of 118 cases from the Middle East. Arch Neurol. 1979 Oct;36(10):610–614. doi: 10.1001/archneur.1979.00500460044004. [DOI] [PubMed] [Google Scholar]
  23. Sever J. L., Krebs H., Ley A., Barbosa L. H., Rubinstein D. Diagnosis of subacute panencephalitis. The value and availability of measles antibody determinations. JAMA. 1974 Apr 29;228(5):604–606. doi: 10.1001/jama.228.5.604. [DOI] [PubMed] [Google Scholar]
  24. Steele R. W., Fuccillo D. A., Hensen S. A., Vincent M. M., Bellanti J. A. Specific inhibitory factors of cellular immunity in children with subacute sclerosing panencephalitis. J Pediatr. 1976 Jan;88(1):56–62. doi: 10.1016/s0022-3476(76)80727-5. [DOI] [PubMed] [Google Scholar]
  25. Swick H. M., Brooks W. H., Roszman T. L., Caldwell D. A heat-stable blocking factor in the plasma of patients with subacute sclerosing panencephalitis. Neurology. 1976 Jan;26(1):84–88. doi: 10.1212/wnl.26.1.84. [DOI] [PubMed] [Google Scholar]
  26. White H. H., Kepes J. H., Kirkpatrick C. H., Schimke R. N. Subacute encephalitis and congenital hypogammaglobulinemia. Arch Neurol. 1972 Apr;26(4):359–365. doi: 10.1001/archneur.1972.00490100089010. [DOI] [PubMed] [Google Scholar]

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