Abstract
It was shown that splenectomized mice could develop a certain resistance to Plasmodium berghei but usually no real immunity, since the infection became chronic, often with high parasitemias. A patent infection lasting at least 2 weeks was necessary for the development of this degree of protection. Prolonged suppression to subpatent levels (sulfonamide treatment), rather than radical cure (chloroquine), after 2 weeks of patency yielded a higher proportion of mice resistant to superinfection. An increasing proportion of B10LP, but not C57BL/Rij or BALB/c, mice cleared their chronic infection spontaneously in time. Chronic patent infections were accompanied by anemia, elevated serum glutamate oxaloacetate transaminase levels, indicating liver pathology, and decreased immune reactivity, but the magnitude to these pathological changes was limited compared with changes in primary, lethal infections in intact controls. Parasitemia and pathology did not always develop synchronously.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dockrell H. M., de Souza J. B., Playfair J. H. The role of the liver in immunity to blood-stage murine malaria. Immunology. 1980 Oct;41(2):421–430. [PMC free article] [PubMed] [Google Scholar]
- Eling W. M. Plasmodium berghei: effect of antithymocyte serum on induction of immunity in the mouse. Exp Parasitol. 1979 Jun;47(3):403–409. doi: 10.1016/0014-4894(79)90093-6. [DOI] [PubMed] [Google Scholar]
- Eling W. M. Role of spleen in morbidity and mortality of Plasmodium berghei infection in mice. Infect Immun. 1980 Dec;30(3):635–641. doi: 10.1128/iai.30.3.635-641.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eling W., Jerusalem C. Active immunization against the malaria parasite Plasmodium berghei in mice: sulfathiazole treatment of a P. berghei infection and development of immunity. Tropenmed Parasitol. 1977 Jun;28(2):158–174. [PubMed] [Google Scholar]
- Garnham P. C. The role of the spleen in protozoal infections with special reference to splenectomy. Acta Trop. 1970;27(1):1–14. [PubMed] [Google Scholar]
- Grun J. L., Weidanz W. P. Immunity to Plasmodium chabaudi adami in the B-cell-deficient mouse. Nature. 1981 Mar 12;290(5802):143–145. doi: 10.1038/290143a0. [DOI] [PubMed] [Google Scholar]
- Oster C. N., Koontz L. C., Wyler D. J. Malaria in asplenic mice: effects of splenectomy, congenital asplenia, and splenic reconstitution on the course of infection. Am J Trop Med Hyg. 1980 Nov;29(6):1138–1142. doi: 10.4269/ajtmh.1980.29.1138. [DOI] [PubMed] [Google Scholar]
- Sengers R. C., Jerusalem C. R., Doesburg W. H. Murine malaria. IV. Disturbed immunological responsiveness during Plasmodium berghei infection. Exp Parasitol. 1971 Aug;30(1):41–53. doi: 10.1016/0014-4894(71)90068-3. [DOI] [PubMed] [Google Scholar]
- Wedderburn N., Turk J. L., Davies D. R., Hutt M. S. Chronic malarial infection of mice: A comparison of single and multiple infections with Plasmodium berghei following P. yoelii. Trans R Soc Trop Med Hyg. 1978;72(6):610–614. doi: 10.1016/0035-9203(78)90013-5. [DOI] [PubMed] [Google Scholar]
- Wiedanz W. P., Rank R. G. Regional immunosuppression induced by Plasmodium berghei yoelii infection in mice. Infect Immun. 1975 Jan;11(1):211–212. doi: 10.1128/iai.11.1.211-212.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]