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. 1982 May;36(2):609–614. doi: 10.1128/iai.36.2.609-614.1982

Increase of mouse resistance to Candida albicans infection by thymosin alpha 1.

F Bistoni, P Marconi, L Frati, E Bonmassar, E Garaci
PMCID: PMC351272  PMID: 7085074

Abstract

Studies were carried out to assess the ability of thymosin alpha 1 to prolong the survival of mice challenged with Candida albicans. Two- to four-month-old mice were treated with graded doses of thymosin alpha 1 before, after, or before and after intravenous challenge with C. albicans. Significant resistance ot lethal infection was afforded by 100 micrograms of thymosin alpha 1 per kg given before or before and after challenge, whereas no protection was found in mice treated with thymosin alpha 1 administered at any dose level after inoculation. Pretreatment with thymosin alpha 1 also prevented the increased susceptibility to C. albicans infection of mice pretreated with cyclophosphamide on day -6. The results showed that thymosin alpha 1 was capable of protecting untreated or cyclophosphamide-pretreated mice from C. albicans infection at an optimal dose and schedule of administration.

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Selected References

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