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. 1981 Feb;31(2):775–782. doi: 10.1128/iai.31.2.775-782.1981

Characterization of plasmids and plasmid-associated determinants of Yersinia enterocolitica pathogenesis.

D A Portnoy, S L Moseley, S Falkow
PMCID: PMC351377  PMID: 7216474

Abstract

Yersinia enterocolitica isolates harboring a particular species of plasmid deoxyribonucleic acid showed a high degree of lethality for gerbils and caused the detachment of HEp-2 tissue cell monolayers. Strains cured of their plasmid deoxyribonucleic acid showed loss of these properties. However, invasiveness of HEp-2 cells was shown not to be a plasmid-mediated property. The expression of plasmid-associated properties, including at least three major outer membrane polypeptides, occurred during growth at 37 but not at 25 degrees C and was related to the concentration of calcium in the growth medium. The plasmid species associated with these properties ranged in molecular mass from 40 x 10(6) to 48 x 10(6) daltons and comprised a family of related plasmids.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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