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. 1981 May;32(2):480–483. doi: 10.1128/iai.32.2.480-483.1981

Failure of chlorpromazine to inhibit fluid accumulation caused by Escherichia coli heat-stable enterotoxin in suckling mice.

T Takeda, T Honda, Y Takeda, T Miwatani
PMCID: PMC351470  PMID: 7195875

Abstract

We studied the effect of chlorpromazine on fluid accumulation caused by purified heat-stable enterotoxin (ST) from enterotoxigenic Escherichia coli in suckling mice. We found that chlorpromazine inactivated ST itself in vitro, but did not inhibit the activity of ST in the intestines.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abbey D. M., Knoop F. C. Effect of chlorpromazine on the secretory activity of Escherichia coli heat-stable enterotoxin. Infect Immun. 1979 Dec;26(3):1000–1003. doi: 10.1128/iai.26.3.1000-1003.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Evans D. J., Jr, Chen L. C., Curlin G. T., Evans D. G. Stimulation of adenyl cyclase by Escherichia coli enterotoxin. Nat New Biol. 1972 Apr 5;236(66):137–138. doi: 10.1038/newbio236137a0. [DOI] [PubMed] [Google Scholar]
  3. Field M., Graf L. H., Jr, Laird W. J., Smith P. L. Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine. Proc Natl Acad Sci U S A. 1978 Jun;75(6):2800–2804. doi: 10.1073/pnas.75.6.2800. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Holmgren J., Lange S., Lönnroth I. Reversal of cyclic AMP-mediated intestinal secretion in mice by chlorpromazine. Gastroenterology. 1978 Dec;75(6):1103–1108. [PubMed] [Google Scholar]
  5. Hughes J. M., Murad F., Chang B., Guerrant R. L. Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli. Nature. 1978 Feb 23;271(5647):755–756. doi: 10.1038/271755a0. [DOI] [PubMed] [Google Scholar]
  6. Lönnroth I., Andrén B., Lange S., Martinsson K., Holmgren J. Chlorpromazine reverses diarrhea in piglets caused by enterotoxigenic Escherichia coli. Infect Immun. 1979 Jun;24(3):900–905. doi: 10.1128/iai.24.3.900-905.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Rabbani G. H., Greenough W. B., 3rd, Holmgren J., Lönnroth I. Chlorpromazine reduces fluid-loss in cholera. Lancet. 1979 Feb 24;1(8113):410–412. doi: 10.1016/s0140-6736(79)90885-7. [DOI] [PubMed] [Google Scholar]
  8. Schafer D. E., Lust W. D., Sircar B., Goldberg N. D. Elevated concentration of adenosine 3':5'-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin. Proc Natl Acad Sci U S A. 1970 Oct;67(2):851–856. doi: 10.1073/pnas.67.2.851. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Sharp G. W., Hynie S. Stimulation of intestinal adenyl cyclase by cholera toxin. Nature. 1971 Jan 22;229(5282):266–269. doi: 10.1038/229266a0. [DOI] [PubMed] [Google Scholar]
  10. Takeda T., Takeda Y., Miwatani T., Ohtomo N. Detection of cholera enterotoxin activity in suckling hamsters. Infect Immun. 1978 Feb;19(2):752–754. doi: 10.1128/iai.19.2.752-754.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Takeda Y., Takeda T., Yano T., Yamamoto K., Miwatani T. Purification and partial characterization of heat-stable enterotoxin of enterotoxigenic Escherichia coli. Infect Immun. 1979 Sep;25(3):978–985. doi: 10.1128/iai.25.3.978-985.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wolff J., Jones A. B. Inhibition of hormone-sensitive adenyl cyclase by phenothiazines. Proc Natl Acad Sci U S A. 1970 Feb;65(2):454–459. doi: 10.1073/pnas.65.2.454. [DOI] [PMC free article] [PubMed] [Google Scholar]

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