Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1981 Jun;32(3):995–999. doi: 10.1128/iai.32.3.995-999.1981

Inhibition of human herpesviruses by combination of acyclovir and human leukocyte interferon.

M J Levin, P L Leary
PMCID: PMC351549  PMID: 6166569

Abstract

Human leukocytes interferon in low concentrations (1 to 5 U/ml) enhanced the antiviral effect of acyclovir against herpes simplex virus, varicella-zoster virus, and cytomegalovirus grown in human fibroblasts. This occurred without additive inhibition of the division of human fibroblasts or proliferation of peripheral blood mononuclear cells. The combined antiviral effect was additive against clinical isolates of cytomegalovirus and was synergistic against clinical isolates of the other two viruses. The magnitude of the effect with cytomegalovirus was the same when laboratory and wild-type virus were compared. The persistence of varicella-zoster virus in the presence of acyclovir in infected human cells was also reduced by the addition of interferon.

Full text

PDF
996

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong R. W., Merigan T. C. Varicella zoster virus: interferon production and comparative interferon sensitivity in human cell cultures. J Gen Virol. 1971 Jul;12(1):53–54. doi: 10.1099/0022-1317-12-1-53. [DOI] [PubMed] [Google Scholar]
  2. Berenbaum M. C. A method for testing for synergy with any number of agents. J Infect Dis. 1978 Feb;137(2):122–130. doi: 10.1093/infdis/137.2.122. [DOI] [PubMed] [Google Scholar]
  3. Crumpacker C. S., Schnipper L. E., Zaia J. A., Levin M. J. Growth inhibition by acycloguanosine of herpesviruses isolated from human infections. Antimicrob Agents Chemother. 1979 May;15(5):642–645. doi: 10.1128/aac.15.5.642. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gutterman J. U., Blumenschein G. R., Alexanian R., Yap H. Y., Buzdar A. U., Cabanillas F., Hortobagyi G. N., Hersh E. M., Rasmussen S. L., Harmon M. Leukocyte interferon-induced tumor regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma. Ann Intern Med. 1980 Sep;93(3):399–406. doi: 10.7326/0003-4819-93-3-399. [DOI] [PubMed] [Google Scholar]
  5. Havell E. A., Vilcek J. Production of high-titered interferon in cultures of human diploid cells. Antimicrob Agents Chemother. 1972 Dec;2(6):476–484. doi: 10.1128/aac.2.6.476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Levin M. J., Leary P. L., Arbeit R. D. Effect of acyclovir on the proliferation of human fibroblasts and peripheral blood mononuclear cells. Antimicrob Agents Chemother. 1980 Jun;17(6):947–953. doi: 10.1128/aac.17.6.947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Levin M. J., Parkman R., Oxman M. N., Rappeport J. M., Simpson M., Leary P. L. Proliferative and interferon responses by peripheral blood mononuclear cells after bone marrow transplantation in humans. Infect Immun. 1978 Jun;20(3):678–684. doi: 10.1128/iai.20.3.678-684.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Meyers J. D., McGuffin R. W., Neiman P. E., Singer J. W., Thomas E. D. Toxicity and efficacy of human leukocyte interferon for treatment of cytomegalovirus pneumonia after marrow transplantation. J Infect Dis. 1980 May;141(5):555–562. doi: 10.1093/infdis/141.5.555. [DOI] [PubMed] [Google Scholar]
  9. Rasmussen L., Farley L. B. Inhibition of Herpesvirus hominis replication by human interferon. Infect Immun. 1975 Jul;12(1):104–108. doi: 10.1128/iai.12.1.104-108.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. de Miranda P., Whitley R. J., Blum M. R., Keeney R. E., Barton N., Cocchetto D. M., Good S., Hemstreet G. P., 3rd, Kirk L. E., Page D. A. Acyclovir kinetics after intravenous infusion. Clin Pharmacol Ther. 1979 Dec;26(6):718–728. doi: 10.1002/cpt1979266718. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES