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. 1981 Jun;32(3):1176–1180. doi: 10.1128/iai.32.3.1176-1180.1981

Evidence for Normal Cell-Mediated Immunity in Scrapie-Infected Mice

David T Kingsbury 1,†, Deborah A Smeltzer 1,†, Clarence J Gibbs Jr 1, D Carleton Gajdusek 1
PMCID: PMC351575  PMID: 6454663

Abstract

Comparisons between mixed lymphocyte cultures of splenocytes from scrapie-infected and normal mouse brain-inoculated control mice did not reveal any evidence of an impaired cell-mediated immune response in scrapie-infected mice. Likewise, mixed lymphocyte cultures of splenocytes from scrapie-infected and normal mice demonstrated that infected spleen cells had no scrapie-specific antigens on their surfaces. These data suggested that the absence of a detectable scrapie-specific immune response in infected mice was the result of an absence of an exposed scrapie-specific antigen and not due to any direct effect on the immune system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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