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. 1977 Apr;11(4):580–584. doi: 10.1128/aac.11.4.580

Effect of Antibiotics on Chemotaxis of Human Leukocytes

Arne Forsgren 1, David Schmeling 1,1
PMCID: PMC352031  PMID: 856009

Abstract

The effect of 20 different antibiotics on chemotaxis by human neutrophils was studied. Human leukocytes incubated with chloramphenicol, rifampin, sodium fusidate, and tetracyclines in vitro showed markedly depressed migration. The mechanisms by which these antibiotics affect leukotaxis are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMBROSE C. T., COONS A. H. Studies on antibody production. VIII. The inhibitory effect of chloramphenicol on the synthesis of antibody in tissue culture. J Exp Med. 1963 Jun 1;117:1075–1088. doi: 10.1084/jem.117.6.1075. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Carruthers B. M. Leukocyte motility. II. Effect of absence of glucose in medium; effect of presence of deoxyglucose, dinitrophenol, puromycin, actinomycin D, and trypsin on the response to chemotactic substance; effect of segregation of cells from chemotactic substance. Can J Physiol Pharmacol. 1967 Mar;45(2):269–280. doi: 10.1139/y67-029. [DOI] [PubMed] [Google Scholar]
  3. Colaizzi J. L., Klink P. R. pH-Partition behavior of tetracyclines. J Pharm Sci. 1969 Oct;58(10):1184–1189. doi: 10.1002/jps.2600581003. [DOI] [PubMed] [Google Scholar]
  4. Cornely H. P. Reversal of chemotaxis in vitro and chemotactic activity of leukocyte fractions. Proc Soc Exp Biol Med. 1966 Jul;122(3):831–835. doi: 10.3181/00379727-122-31263. [DOI] [PubMed] [Google Scholar]
  5. DOWNEY R. J., PISANO J. C. SOME EFFECTS OF ANTIMICROBIAL COMPOUNDS ON PHAGOCYTOSIS IN VITRO. J Reticuloendothel Soc. 1965 May;2:75–88. [PubMed] [Google Scholar]
  6. Forsgren A., Schmeling D., Quie P. G. Effect of tetracycline on the phagocytic function of human leukocytes. J Infect Dis. 1974 Oct;130(4):412–415. doi: 10.1093/infdis/130.4.412. [DOI] [PubMed] [Google Scholar]
  7. Gimber P. E., Rafter G. W. The interaction of Escherichia coli endotoxin with leukocytes. Arch Biochem Biophys. 1969 Dec;135(1):14–20. doi: 10.1016/0003-9861(69)90510-4. [DOI] [PubMed] [Google Scholar]
  8. Gnarpe H., Leslie D. Tetracyclines and host defence mechanisms. Doxycycline interference with phagocytosis of Escherichia coli. Microbios. 1974 Jun-Jul;10A SUPPL(41):127–138. [PubMed] [Google Scholar]
  9. Grassi G. G., Pozzi E. Effect of rifampicin on delayed-hypersensitivity reactions. J Infect Dis. 1972 Nov;126(5):542–544. doi: 10.1093/infdis/126.5.542. [DOI] [PubMed] [Google Scholar]
  10. Hartmann G., Honikel K. O., Knüsel F., Nüesch J. The specific inhibition of the DNA-directed RNA synthesis by rifamycin. Biochim Biophys Acta. 1967;145(3):843–844. doi: 10.1016/0005-2787(67)90147-5. [DOI] [PubMed] [Google Scholar]
  11. Kernbaum S. Pouvoir candidacide des polynucléaires neutrophiles humains et chimiothérapie antibactérienne. Pathol Biol (Paris) 1974 Nov;22(9):789–794. [PubMed] [Google Scholar]
  12. Lehrer R. I. Effects of colchicine and chloramphenicol on the oxidative metabolism and phagocytic activity of human neutrophils. J Infect Dis. 1973 Jan;127(1):40–48. doi: 10.1093/infdis/127.1.40. [DOI] [PubMed] [Google Scholar]
  13. MUNOZ J., GEISTER R. Inhibition of phagocytosis by aureomycin. Proc Soc Exp Biol Med. 1950 Nov;75(2):367–370. doi: 10.3181/00379727-75-18201. [DOI] [PubMed] [Google Scholar]
  14. Mandell G. L., Vest T. K. Killing of intraleukocytic Staphylococcus aureus by rifampin: in-vitro and in-vivo studies. J Infect Dis. 1972 May;125(5):486–490. doi: 10.1093/infdis/125.5.486. [DOI] [PubMed] [Google Scholar]
  15. Martin R. R., Warr G. A., Couch R. B., Yeager H., Knight V. Effects of tetracycline on leukotaxis. J Infect Dis. 1974 Feb;129(2):110–116. doi: 10.1093/infdis/129.2.110. [DOI] [PubMed] [Google Scholar]
  16. Martin R. R., Warr G., Couch R., Knight V. Chemotaxis of human leukocytes: responsiveness to Mycoplasma pneumoniae. J Lab Clin Med. 1973 Apr;81(4):520–529. [PubMed] [Google Scholar]
  17. Nelson R. D., Quie P. G., Simmons R. L. Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes. J Immunol. 1975 Dec;115(6):1650–1656. [PubMed] [Google Scholar]
  18. Odegaard A., Lamvik J. The effect of phenylbutazone and chloramphenicol on phagocytosis of radiolabelled Candida albicans by human monocytes cultured in vitro. Acta Pathol Microbiol Scand C. 1976 Feb;84(1):37–44. doi: 10.1111/j.1699-0463.1976.tb03597.x. [DOI] [PubMed] [Google Scholar]
  19. Park J. K., Dow R. C. The uptake and localization of tetracycline in human blood cells. Br J Exp Pathol. 1970 Apr;51(2):179–182. [PMC free article] [PubMed] [Google Scholar]
  20. Serrou B., Solassol C., Joyeux H., Pujol H., Romieu C. Immunosuppressive effect of rifampicin. Transplantation. 1972 Nov;14(5):654–655. doi: 10.1097/00007890-197211000-00020. [DOI] [PubMed] [Google Scholar]
  21. Snyderman R., Wohlenberg C., Notkins A. L. Inflammation and viral infection: chemotactic activity resulting from the interaction of antiviral antibody and complement with cells infected with herpes simplex virus. J Infect Dis. 1972 Aug;126(2):207–209. doi: 10.1093/infdis/126.2.207. [DOI] [PubMed] [Google Scholar]
  22. WARD P. A., COCHRANE C. G., MUELLER-EBERHARD H. J. THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO. J Exp Med. 1965 Aug 1;122:327–346. doi: 10.1084/jem.122.2.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Ward P. A., Cohen S., Flanagan T. D. Leukotactic factors elaborated by virus-infected tissues. J Exp Med. 1972 May 1;135(5):1095–1103. doi: 10.1084/jem.135.5.1095. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Ward P. A. Insubstantial leukotaxis. J Lab Clin Med. 1972 Jun;79(6):873–877. [PubMed] [Google Scholar]
  25. Ward P. A., Lepow I. H., Newman L. J. Bacterial factors chemotactic for polymorphonuclear leukocytes. Am J Pathol. 1968 Apr;52(4):725–736. [PMC free article] [PubMed] [Google Scholar]
  26. Wilkinson P. C. Leucocyte locomotion and chemotaxis. The influence of divalent cations and cation ionophores. Exp Cell Res. 1975 Jul;93(2):420–426. doi: 10.1016/0014-4827(75)90468-1. [DOI] [PubMed] [Google Scholar]

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