Abstract
Cefuroxime, a new parenteral cephalosporin was compared with cephalothin by broth microdilution susceptibility testing against 5,887 routine clinical bacterial isolates in four large clinical laboratories. The minimal inhibitory concentrations (MICs) of cefuroxime against the Enterobacteriaceae were consistently lower than those of cephalothin. This was most striking among the Enterobacter species, which were generally susceptible to cefuroxime (MIC ≤ 8 μg/ml), but resistant to cephalothin. Similar results occurred with Haemophilus species, Acinetobacter anitratus, meningococci, and Aeromonas hydrophilia, but Pseudomonas species and enterococci were resistant to high concentrations of both drugs. Streptococci showed slightly greater susceptibility to cefuroxime than to cephalothin. By contrast, staphylococci were more susceptible to cephalothin. Bacteroides fragilis was resistant to cefuroxime, but other anaerobes were generally susceptible.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ernst E. C., Berger S., Barza M., Jacobus N. V., Tally F. P. Activity of cefamandole and other cephalosporins against aerobic and anaerobic bacteria. Antimicrob Agents Chemother. 1976 May;9(5):852–855. doi: 10.1128/aac.9.5.852. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eykyn S., Jenkins C., King A., Phillips I. Antibacterial activity of cefuroxime, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cefamandole. Antimicrob Agents Chemother. 1976 Apr;9(4):690–695. doi: 10.1128/aac.9.4.690. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Foord R. D. Cefuroxime: human pharmacokinetics.. Antimicrob Agents Chemother. 1976 May;9(5):741–747. doi: 10.1128/aac.9.5.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jones R. N., Fuchs P. C. Identification and antimicrobial susceptibility of 250 Bacteriodes fragilis subspecies tested by broth microdilution methods. Antimicrob Agents Chemother. 1976 Apr;9(4):719–721. doi: 10.1128/aac.9.4.719. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Norrby R., Brorsson J. E., Seeberg S. Comparative study of the in vitro antibacterial activity of cefoxitin, cefuroxine, and cephaloridine. Antimicrob Agents Chemother. 1976 Mar;9(3):506–510. doi: 10.1128/aac.9.3.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Callaghan C. H., Sykes R. B., Griffiths A., Thornton J. E. Cefuroxime, a new cephalosporin antibiotic: activity in vitro. Antimicrob Agents Chemother. 1976 Mar;9(3):511–519. doi: 10.1128/aac.9.3.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Callaghan C. H., Sykes R. B., Ryan D. M., Foord R. D., Muggleton P. W. Cefuroxime - a new cephalosporin antibiotic. J Antibiot (Tokyo) 1976 Jan;29(1):29–37. doi: 10.7164/antibiotics.29.29. [DOI] [PubMed] [Google Scholar]
- Richmond M. H., Wotton S. Comparative study of seven cephalosporins: susceptibility to beta-lactamases and ability to penetrate the surface layers of Escherichia coli. Antimicrob Agents Chemother. 1976 Aug;10(2):219–222. doi: 10.1128/aac.10.2.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ryan D. M., O'Callaghan C., Muggleton P. W. Cefuroxime, a new cephalosporin antibiotic: activity in vivo. Antimicrob Agents Chemother. 1976 Mar;9(3):520–525. doi: 10.1128/aac.9.3.520. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tally F. P., Jacobus N. V., Bartlett J. G., Gorbach S. L. Susceptibility of anaerobes to cefoxitin and other cephalosporins. Antimicrob Agents Chemother. 1975 Feb;7(2):128–132. doi: 10.1128/aac.7.2.128. [DOI] [PMC free article] [PubMed] [Google Scholar]