Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1978 Feb;13(2):170–176. doi: 10.1128/aac.13.2.170

Netilmicin: Clinical Efficacy, Tolerance, and Toxicity

Anand P Panwalker 1, James B Malow 1, Victoria M Zimelis 1, George G Jackson 1
PMCID: PMC352208  PMID: 348092

Abstract

Netilmicin, a new aminoglycoside antibiotic, has increased in vitro bactericidal activity against many strains of Enterobacteriaceae as compared to other aminoglycosides. It is a poor substrate for some of the common gentamicin-inactivating enzymes, and it has minimal toxicity in experimental animals. In 27 hospitalized patients, clinical cure was achieved in all, and the initial infecting organism persisted in only one. Therapeutic serum and urine levels were easily obtained in most patients. No ototoxicity was observed in two patients whose treatment required inordinately high serum levels and in whom other risk factors were present. Ototoxicity in 1 of 21 patients studied was unilateral, partially reversible, and not associated with high serum levels. Although nephrotoxicity occurred in 4 of 25 patients (16%), other host factors could have accounted for the toxicity in two patients. A new observation, not noted with other aminoglycoside antibiotics, was the elevation of serum alkaline phosphatase in 43% of the patients studied.

Full text

PDF
171

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Briedis D. J., Robson H. G. Comparative activity of netilmicin, gentamicin, amikacin, and tobramycin against Pseudomonas aeruginosa and Enterobacteriaceae. Antimicrob Agents Chemother. 1976 Oct;10(4):592–597. doi: 10.1128/aac.10.4.592. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brown K. N., Benedictson J., Swanby S. In vitro comparison of gentamicin, tobramycin, sisomicin, and netilmicin. Antimicrob Agents Chemother. 1976 Oct;10(4):768–769. doi: 10.1128/aac.10.4.768. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dhawan V., Marso E., Martin W. J., Young L. S. In vitro studies with netilmicin compared with amikacin, gentamicin, and tobramycin. Antimicrob Agents Chemother. 1977 Jan;11(1):64–73. doi: 10.1128/aac.11.1.64. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Flournoy D. J. Sisomicin versus netilmicin: in vitro susceptibility testing. Antimicrob Agents Chemother. 1976 Nov;10(5):864–865. doi: 10.1128/aac.10.5.864. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fu K. P., Neu H. C. In vitro study of netilmicin compared with other aminoglycosides. Antimicrob Agents Chemother. 1976 Sep;10(3):526–534. doi: 10.1128/aac.10.3.526. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hewitt W. L. Gentamicin: toxicity in perspective. Postgrad Med J. 1974 Nov;50 (Suppl 7):55–61. [PubMed] [Google Scholar]
  7. Jackson G. G., Arcieri G. Ototoxicity of gentamicin in man: a survey and controlled analysis of clinical experience in the United States. J Infect Dis. 1971 Dec;124 (Suppl):S130–S137. doi: 10.1093/infdis/124.supplement_1.s130. [DOI] [PubMed] [Google Scholar]
  8. Kabins S. A., Nathan C., Cohen S. In vitro comparison of netilmicin, a semisynthetic derivative of sisomicin, and four other aminoglycoside antibiotics. Antimicrob Agents Chemother. 1976 Jul;10(1):139–145. doi: 10.1128/aac.10.1.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kantor R. J., Norden C. W. In vitro activity of netilmicin, gentamicin, and amikacin. Antimicrob Agents Chemother. 1977 Jan;11(1):126–131. doi: 10.1128/aac.11.1.126. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Meyer R. D., Draus L. L., Pasieczinik K. A. In vitro susceptibility of gentamicin-resistant Enterobacteriaceae and Pseudomonas aeruginosa to netilmicin and selected aminoglycoside antibiotics. Antimicrob Agents Chemother. 1976 Oct;10(4):677–681. doi: 10.1128/aac.10.4.677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Meyer R. D., Lewis R. P., Carmalt E. D., Finegold S. M. Amikacin therapy for serious gram-negative bacillary infections. Ann Intern Med. 1975 Dec;83(6):790–800. doi: 10.7326/0003-4819-83-6-790. [DOI] [PubMed] [Google Scholar]
  12. Meyers B. R., Hirschman S. Z. Antimicrobial activity in vitro of netilmicin and comparison with sisomicin, gentamicin, and tobramycin. Antimicrob Agents Chemother. 1977 Jan;11(1):118–121. doi: 10.1128/aac.11.1.118. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Miller G. H., Arcieri G., Weinstein M. J., Waitz J. A. Biological activity of netilmicin, a broad-spectrum semisynthetic aminoglycoside antibiotic. Antimicrob Agents Chemother. 1976 Nov;10(5):827–836. doi: 10.1128/aac.10.5.827. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Phillips I., Smith A., Shannon K. Antibacterial activity of netilmicin, a new aminoglycoside antibiotic, compared with that of gentamicin. Antimicrob Agents Chemother. 1977 Mar;11(3):402–406. doi: 10.1128/aac.11.3.402. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rahal J. J., Jr, Simberkoff M. S., Kagan K., Moldover N. H. Bactericidal efficacy of Sch 20569 and amikacin against gentamicin-sensitive and -resistant organisms. Antimicrob Agents Chemother. 1976 Apr;9(4):595–599. doi: 10.1128/aac.9.4.595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Riff L. J., Moreschi G. Netilmicin and gentamicin: comparative pharmacology in humans. Antimicrob Agents Chemother. 1977 Apr;11(4):609–614. doi: 10.1128/aac.11.4.609. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Smith C. R., Baughman K. L., Edwards C. Q., Rogers J. F., Lietman P. S. Controlled comparison of amikacin and gentamicin. N Engl J Med. 1977 Feb 17;296(7):349–353. doi: 10.1056/NEJM197702172960701. [DOI] [PubMed] [Google Scholar]
  18. Smith J. A., Morgan J. R., Mogyoros M. In vitro activity of netilmicin. Antimicrob Agents Chemother. 1977 Feb;11(2):362–364. doi: 10.1128/aac.11.2.362. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES