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. 1978 Feb;13(2):342–343. doi: 10.1128/aac.13.2.342

Comparative Activities of Selected Beta-Lactam Antibiotics Against Haemophilus influenzae

James H Jorgensen 1, Gary A Alexander 1
PMCID: PMC352238  PMID: 306221

Abstract

The comparative activities of ampicillin, cefamandole, cefoxitin, cefaclor, and cefatrizine against both beta-lactamase-producing and non-beta-lactamase-producing isolates of Haemophilus influenzae were determined by using an agar dilution susceptibility test procedure. Ampicillin was the most active drug tested against non-beta-lactamase-producing isolates, whereas cefamandole was most active against beta-lactamase-producing strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Jacobson J. A., McCormick J. B., Hayes P., Thornsberry C., Kirvin L. Epidemiologic characteristics of infections caused by ampicillin-resistant Hemophilus influenzae. Pediatrics. 1976 Sep;58(3):388–391. [PubMed] [Google Scholar]
  2. Jorgensen J. H., Jones P. M. Simplified medium for ampicillin susceptibility testing of Haemophilus influenzae. Antimicrob Agents Chemother. 1975 Feb;7(2):186–190. doi: 10.1128/aac.7.2.186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Jorgensen J. H., Lee J. C., Alexander G. A. Rapid penicillinase paper strip test for detection of beta-lactamase-producing Haemophilus influenzae and Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1977 Jun;11(6):1087–1088. doi: 10.1128/aac.11.6.1087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kammer R. B., Preston D. A., Turner J. R., Hawley L. C. Rapid detection of ampicillin-resistant Haemophilus influenzae and their susceptibility to sixteen antibiotics. Antimicrob Agents Chemother. 1975 Jul;8(1):91–94. doi: 10.1128/aac.8.1.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kattan S., Cavanagh P., Williams J. D. Relationship between beta-lactamase production by Haemophilus influenzae and sensitivities to penicillins and cephalosporins. J Antimicrob Chemother. 1975 Mar;1(1):79–84. doi: 10.1093/jac/1.1.79. [DOI] [PubMed] [Google Scholar]
  6. Khan W., Ross S., Rodriguez W., Controni G., Saz A. K. Haemophilus influenzae type B resistant to ampicillin. A report of two cases. JAMA. 1974 Jul 15;229(3):298–301. [PubMed] [Google Scholar]
  7. Manten A., van Klingeren B., Dessens-Kroon M. Chloramphenicol resistance in Haemophilus influenzae. Lancet. 1976 Mar 27;1(7961):702–702. doi: 10.1016/s0140-6736(76)92832-4. [DOI] [PubMed] [Google Scholar]
  8. Neu H. C. Cefoxitin, a semisynthetic cephamycin antibiotic: antibacterial spectrum and resistance to hydrolysis by gram-negative beta-lactamases. Antimicrob Agents Chemother. 1974 Aug;6(2):170–176. doi: 10.1128/aac.6.2.170. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Shurin P. A., Pelton S. I., Scheifele D., Klein J. O. Otitis media caused by non-typable, ampicillin-resistant strains of Haemophilus influenzae. J Pediatr. 1976 Apr;88(4 Pt 1):646–649. doi: 10.1016/s0022-3476(76)80028-5. [DOI] [PubMed] [Google Scholar]
  10. Todd J. K., Bruhn F. W. Severe Haemophilus influenzae infections. Am J Dis Child. 1975 May;129(5):607–611. doi: 10.1001/archpedi.1975.02120420047016. [DOI] [PubMed] [Google Scholar]
  11. Tomeh M. O., Starr S. E., McGowan J. E., Jr, Terry P. M., Nahmias A. J. Ampicillin-resistant Haemophilus influenzae type B infection. JAMA. 1974 Jul 15;229(3):295–297. [PubMed] [Google Scholar]
  12. Washington J. A. The in vitro spectrum of the cephalosporins. Mayo Clin Proc. 1976 Apr;51(4):237–250. [PubMed] [Google Scholar]

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