Abstract
A simple, reliable, and inexpensive assay for quantitation of the imidazole drugs miconazole, RV 40,500, and RV 41,400 was tested. The assay, similar to a Kirby-Bauer test, was sensitive to less than or equal to 0.2 μg of drug per ml and linear from less than or equal to 0.2 to 10.0 μg/ml. Concentration of inoculum and agar depth in test plates was not as critical as the type of medium, amount of inoculum, or type of drug used.
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Selected References
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- Bennett J. E. Chemotherapy of systemic mycoses (first of two parts). N Engl J Med. 1974 Jan 3;290(1):30–32. doi: 10.1056/NEJM197401032900107. [DOI] [PubMed] [Google Scholar]
- Levine H. B. R34000, a dioxolane imidazole in the therapy for experimental coccidioidomycosis. Comparison with miconazole and econazole. Chest. 1976 Dec;70(6):755–759. doi: 10.1378/chest.70.6.755. [DOI] [PubMed] [Google Scholar]
- Levine H. B., Stevens D. A., Cobb J. M., Gebhardt A. E. Miconazole in coccidioidomycosis. I. Assays of activity in mice and in vitro. J Infect Dis. 1975 Oct;132(4):407–414. doi: 10.1093/infdis/132.4.407. [DOI] [PubMed] [Google Scholar]
- Miller R. P., Bates J. H. Amphotericin B toxicity. A follow-up report of 53 patients. Ann Intern Med. 1969 Dec;71(6):1089–1095. doi: 10.7326/0003-4819-71-6-1089. [DOI] [PubMed] [Google Scholar]
- Sung J. P., Grendahl J. G., Levine H. B. Intravenous and intrathecal miconazole therapy for systemic mycoses. West J Med. 1977 Jan;126(1):5–13. [PMC free article] [PubMed] [Google Scholar]