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. 1978 Dec;14(6):842–845. doi: 10.1128/aac.14.6.842

Effect of 9-(2-Hydroxyethoxymethyl)guanine on Herpesvirus-Induced Keratitis and Iritis in Rabbits

Herbert E Kaufman 1, Emily D Varnell 1, Ysolina M Centifanto 1, Stephen D Rheinstrom 1
PMCID: PMC352567  PMID: 217301

Abstract

Drugs used for the inhibition of DNA viruses, such as iododeoxyuridine, adenine arabinoside, or trifluorothymidine, are not biochemically selective in their action and also interfere with normal cellular functions. The recently reported 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine) is selectively phosphorylated by viral thymidine kinase but not by normal cellular thymidine kinase. Our present studies show that the acycloguanosine is as effective in treating herpetic keratitis in the rabbit as iododeoxyuridine and trifluorothymidine when given topically as an ointment. It is also effective when given intravenously for the treatment of herpetic iritis and is effective in preventing death from encephalitis in rabbits.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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