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. 1978 Dec;14(6):846–850. doi: 10.1128/aac.14.6.846

UK-18,892: Resistance to Modification by Aminoglycoside-Inactivating Enzymes

R J Andrews 1, K W Brammer 1, H E Cheeseman 1, S Jevons 1
PMCID: PMC352568  PMID: 742872

Abstract

UK-18,892, a new semisynthetic aminoglycoside, was active against bacteria possessing aminoglycoside-inactivating enzymes, with the exception of some known to possess AAC(6′) or AAD(4′) enzymes. This activity has been rationalized by using cell-free extracts of bacteria containing known inactivating enzymes, where it was shown that UK-18,892 was not a substrate for the APH(3′), AAD(2″), AAC(3), and AAC(2′) enzymes. It was also demonstrated that UK-18,892 protected mice against lethal infections caused by organisms possessing aminoglycoside-inactivating enzymes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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