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. 1978 Dec;14(6):856–865. doi: 10.1128/aac.14.6.856

Cation Transport Alteration Associated with Plasmid-Determined Resistance to Cadmium in Staphylococcus aureus

Alison A Weiss 1,†, Simon Silver 1, T G Kinscherf 1
PMCID: PMC352570  PMID: 742873

Abstract

Plasmid-determined resistance to cadmium has only been found with plasmids from Staphylococcus aureus. Resistance to cadmium was associated with a lower accumulation of Cd2+ ions by the plasmid-bearing resistant cells. Cadmium accumulation by susceptible cells was energy dependent and had those characteristics usually associated with a transmembrane active transport system. There was a specific interrelationship between cadmium accumulation and manganese accumulation and retention. Cd2+ inhibited the uptake of Mn2+ and accelerated the loss of intracellular Mn2+ by the susceptible cells, but was without effect on Mn2+ transport in resistant S. aureus cells. Under similar conditions, there was no differential effect of Cd2+ on Mg2+, Zn2+, Co2+, Ni2+, or Rb+ accumulation or exchange between the susceptible and the resistant strains.

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Selected References

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