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. 1979 Feb;15(2):263–268. doi: 10.1128/aac.15.2.263

Factors Contributing to Resistance to Beta-Lactam Antibiotics in Bacteroides fragilis

Barbro Olsson 1,2, Kathrine Dornbusch 1,2, Carl Erik Nord 1,2
PMCID: PMC352644  PMID: 426517

Abstract

Fifteen strains of Bacteroides fragilis, five highly resistant, five moderately resistant, and five susceptible to benzylpenicillin and cephaloridine, were tested for β-lactamase production. In the highly resistant and the moderately resistant groups of strains, a correlation between formation of β-lactamase and minimal inhibitory concentrations was demonstrated. In the presence of the β-lactamase inhibitors clavulanic acid and CP-45,899 at concentrations of 1 μg/ml, the susceptibility to cephaloridine increased fourfold or more in the β-lactamase-producing strains. Crypticity measurements (β-lactamase activity broken/intact cells) with cephaloridine as substrate could indicate a diffusion barrier in the cell wall.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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