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. 1979 Nov;16(5):554–560. doi: 10.1128/aac.16.5.554

Antibiotics and suppression of lymphocyte function in vitro.

G Banck, A Forsgren
PMCID: PMC352904  PMID: 316685

Abstract

The effects on the mitogenic response of human T lymphocytes were studied for 20 different antibiotics. No apparent inhibitory effect could be detected for penicillins, cephalosporins, aminoglycosides, chloramphenicol, sulfamethoxazole, trimethoprim, nalidixic acid, and 5-fluorocytosine. There were effects at high concentrations with erythromycin, clindamycin, and rifampin, and these antibiotics could also be shown to depress the mitogenic response of B lymphocytes. With fusidic acid, nitrofurantoin, and doxycycline there was an inhibiting effect at low concentrations on the mitogenic responses of B and T lymphocytes and on in vitro antibody production. Protein synthesis in unstimulated lymphocytes was also inhibited. Some antibiotics thus may impair the function of human lymphocytes in vitro.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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