Abstract
The pharmacokinetic properties of piperacillin, a piperazine derivative of ampicillin, were determined in seven patients with creatinine clearances less than 7 ml/min who were undergoing chronic, intermittent hemodialysis. A two-compartment linear model was used to analyze the data. Mean elimination half-life was 1.26 +/- 0.1 h; the mean elimination constant was 0.95 +/- 0.08 h-1; the mean volume of distribution was 0.16 +/- 0.02 liters/kg of body weight; the mean volume of the central compartment was 0.10 +/- 0.01 liters/kg of body weight; and the mean clearance was 0.09 +/- 0.01 liters/h per kg of body weight. Mean elimination half-life while off dialysis of 2.1 h.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Batra V. K., Morrison J. A., Lasseter K. C., Joy V. A. Piperacillin kinetics. Clin Pharmacol Ther. 1979 Jul;26(1):41–53. doi: 10.1002/cpt197926141. [DOI] [PubMed] [Google Scholar]
- Bennett J. V., Brodie J. L., Benner E. J., Kirby W. M. Simplified, accurate method for antibiotic assay of clinical specimens. Appl Microbiol. 1966 Mar;14(2):170–177. doi: 10.1128/am.14.2.170-177.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bischoff K. B., Dedrick R. L. Generalized solution to linear, to-compartment, open model for drug distribution. J Theor Biol. 1970 Oct;29(1):63–68. doi: 10.1016/0022-5193(70)90119-0. [DOI] [PubMed] [Google Scholar]
- Evans M. A., Wilson P., Leung T., Williams J. D. Pharmacokinetics of piperacillin following intravenous administration. J Antimicrob Chemother. 1978 May;4(3):255–261. doi: 10.1093/jac/4.3.255. [DOI] [PubMed] [Google Scholar]
- Fu K. P., Neu H. C. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother. 1978 Mar;13(3):358–367. doi: 10.1128/aac.13.3.358. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoffman T. A., Cestero R., Bullock W. E. Pharmacodynamics of carbenicillin in hepatic and renal failure. Ann Intern Med. 1970 Aug;73(2):173–178. doi: 10.7326/0003-4819-73-2-173. [DOI] [PubMed] [Google Scholar]
- Klastersky J., Daneau D., Swings G., Weerts D. Antibacterial activity in serum and urine as a therapeutic guide in bacterial infections. J Infect Dis. 1974 Feb;129(2):187–193. doi: 10.1093/infdis/129.2.187. [DOI] [PubMed] [Google Scholar]
- Neu H. C., Garvey G. J. Comparative in vitro activity and clinical pharmacology of ticarcillin and carbenicillin. Antimicrob Agents Chemother. 1975 Oct;8(4):457–462. doi: 10.1128/aac.8.4.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neu H. C. The penicillins. II. Overview of pharmacology, toxicology, and clinical use. N Y State J Med. 1977 May;77(6):962–967. [PubMed] [Google Scholar]
- Pancoast S. J., Neu H. C. Kinetics of mezlocillin and carbenicillin. Clin Pharmacol Ther. 1978 Jul;24(1):108–116. doi: 10.1002/cpt1978241108. [DOI] [PubMed] [Google Scholar]
- Parry M. G., Neu H. C. Ticarcillin for treatment of serious infections with gram-negative bacteria. J Infect Dis. 1976 Nov;134(5):476–485. doi: 10.1093/infdis/134.5.476. [DOI] [PubMed] [Google Scholar]
- Riegelman S., Loo J. C., Rowland M. Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment. J Pharm Sci. 1968 Jan;57(1):117–123. doi: 10.1002/jps.2600570123. [DOI] [PubMed] [Google Scholar]
- Verbist L. In vitro activity of piperacillin, a new semisynthetic penicillin with an unusually broad spectrum of activity. Antimicrob Agents Chemother. 1978 Mar;13(3):349–357. doi: 10.1128/aac.13.3.349. [DOI] [PMC free article] [PubMed] [Google Scholar]