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. 1978 Jan;25(1):408–412. doi: 10.1128/jvi.25.1.408-412.1978

Inhibition of maturation of Rauscher leukemia virus by amino acid analogs.

G A Jamjoom, V L Ng, R B Arlinghaus
PMCID: PMC353938  PMID: 621781

Abstract

Synthesis of primary precursor polyproteins of Rauscher leukemia virus (RLV) core and envelope proteins occurs in the presence of amino acid analogs canavanine and p-fluorophenylalanine, but cleavage of these precursors is severely inhibited or slowed down. After treatment with these agents, the release of characteristic virus or stable virus-like particles is greatly depressed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arcement L. J., Karshin W. L., Naso R. B., Arlinghaus R. B. "gag" polyprotein precursors of Rauscher murine leukemia virus. Virology. 1977 Sep;81(2):284–297. doi: 10.1016/0042-6822(77)90145-3. [DOI] [PubMed] [Google Scholar]
  2. Arcement L. J., Karshin W. L., Naso R. B., Jamjoom G., Arlinghaus R. B. Biosynthesis of Rauscher leukemia viral proteins: presence of p30 and envelope p15 sequences in precursor polypeptides. Virology. 1976 Feb;69(2):763–774. doi: 10.1016/0042-6822(76)90504-3. [DOI] [PubMed] [Google Scholar]
  3. Bolognesi D. P., Langlois A. J., Schäfer W. Polypeptides of mammalian oncornaviruses. IV. Structural components of murine leukemia virus released as soluble antigens in cell culture. Virology. 1975 Dec;68(2):550–555. doi: 10.1016/0042-6822(75)90297-4. [DOI] [PubMed] [Google Scholar]
  4. Eisenman R., Vogt V. M., Diggelmann H. Synthesis of avian RNA tumor virus structural proteins. Cold Spring Harb Symp Quant Biol. 1975;39(Pt 2):1067–1075. doi: 10.1101/sqb.1974.039.01.122. [DOI] [PubMed] [Google Scholar]
  5. Friis R. R., Ogura H., Gelderblom H., Halpern M. S. The defective maturation of viral progeny with a temperature-sensitive mutant of avian sarcoma virus. Virology. 1976 Aug;73(1):259–272. doi: 10.1016/0042-6822(76)90079-9. [DOI] [PubMed] [Google Scholar]
  6. Hanafusa H., Baltimore D., Smoler D., Watson K. F., Yaniv A., Spiegelman S. Absence of polymerase protein in virions of alpha-type rous sarcoma virus. Science. 1972 Sep 29;177(4055):1188–1191. doi: 10.1126/science.177.4055.1188. [DOI] [PubMed] [Google Scholar]
  7. Harms E., Rodhe W., Friis R. R., Bauer H. Influence of defective virion core proteins on RNA maturation with an avian sarcoma virus. J Virol. 1977 Jan;21(1):419–422. doi: 10.1128/jvi.21.1.419-422.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hunter E., Hayman M. J., Rongey R. W., Vogt P. K. An avian sarcoma virus mutant that is temperature sensitive for virion assembly. Virology. 1976 Jan;69(1):35–49. doi: 10.1016/0042-6822(76)90192-6. [DOI] [PubMed] [Google Scholar]
  9. Jamjoom G. A., Naso R. B., Arlinghaus R. B. Further characterization of intracellular precursor polyproteins of Rauscher leukemia virus. Virology. 1977 May 1;78(1):11–34. doi: 10.1016/0042-6822(77)90075-7. [DOI] [PubMed] [Google Scholar]
  10. Jamjoom G. A., Naso R. B., Arlinghaus R. B. Selective decrease in the rate of cleavage of an intracellular precursor to Rauscher leukemia virus p30 by treatment of infected cells with actinomycin D. J Virol. 1976 Sep;19(3):1054–1072. doi: 10.1128/jvi.19.3.1054-1072.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jamjoom G., Karshin W. L., Naso R. B., Arcement L. J., Arlinghaus R. B. Proteins of Rauscher murine leukemia virus: resolution of a 70,000-dalton, Nonglycosylated polypeptide containing p30 peptide sequences. Virology. 1975 Nov;68(1):135–145. doi: 10.1016/0042-6822(75)90155-5. [DOI] [PubMed] [Google Scholar]
  12. Jones K. J., Waite M. R., Bose H. R. Cleavage of a viral envelope precursor during the morphogenesis of Sindbis virus. J Virol. 1974 Apr;13(4):809–817. doi: 10.1128/jvi.13.4.809-817.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kawai S., Hanafusa H. Isolation of defective mutant of avian sarcoma virus. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3493–3497. doi: 10.1073/pnas.70.12.3493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Keränen S., Käriäinen L. Proteins synthesized by Semliki Forest virus and its 16 temperature-sensitive mutants. J Virol. 1975 Aug;16(2):388–396. doi: 10.1128/jvi.16.2.388-396.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Naso R. B., Arcement L. J., Arlinghaus R. B. Biosynthesis of Rauscher leukemia viral proteins. Cell. 1975 Jan;4(1):31–36. doi: 10.1016/0092-8674(75)90130-0. [DOI] [PubMed] [Google Scholar]
  16. Naso R. B., Arcement L. J., Karshin W. L., Jamjoom G. A., Arlinghaus R. B. A fucose-deficient glycoprotein precursor to Rauscher leukemia virus gp69/71. Proc Natl Acad Sci U S A. 1976 Jul;73(7):2326–2330. doi: 10.1073/pnas.73.7.2326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Racevskis J., Koch G. Viral protein synthesis in Friend erythroleukemia cell lines. J Virol. 1977 Jan;21(1):328–337. doi: 10.1128/jvi.21.1.328-337.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rohrschneider J. M., Diggelmann H., Ogura H., Friis R. R., Bauer H. Defective cleavage of a precursor polypeptide in a temperature-sensitive mutant of avian sarcoma virus. Virology. 1976 Nov;75(1):177–187. doi: 10.1016/0042-6822(76)90016-7. [DOI] [PubMed] [Google Scholar]
  19. Van Zaane D., Dekker-Michielsen J. A., Bloemers H. P. Virus-specific precursor polypeptides in cells infected with Rauscher leukemia virus: synthesis, identification, and processing. Virology. 1976 Nov;75(1):113–129. doi: 10.1016/0042-6822(76)90011-8. [DOI] [PubMed] [Google Scholar]
  20. Yoshinaka Y., Luftig R. B. Murine leukemia virus morphogenesis: cleavage of P70 in vitro can be accompanied by a shift from a concentrically coiled internal strand ("immature") to a collapsed ("mature") form of the virus core. Proc Natl Acad Sci U S A. 1977 Aug;74(8):3446–3450. doi: 10.1073/pnas.74.8.3446. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Zaanie D., Gielkens A. L., Dekker-michielsen M. J., Bloemers H. P. Virus-specific precursor polypeptides in cells infected with Rauscher leukemia virus. Virology. 1975 Oct;67(2):544–552. doi: 10.1016/0042-6822(75)90454-7. [DOI] [PubMed] [Google Scholar]

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