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. 1975 Feb;15(2):420–422. doi: 10.1128/jvi.15.2.420-422.1975

Malignant transformation of hamster kidney cells by BK virus.

M Portolani, G Barbanti-Brodano, M L Placa
PMCID: PMC354469  PMID: 163364

Abstract

Primary hamster kidney cells were transformed by BK virus, a new human papovavirus. Transformed (HKBK) cell produced BK virus T antigen and induced tumors in hamsters that developed antibodies to BK virus T antigen. BK virus was rescued from HKBK cells by Sendai virus-assisted fusion with permissive cells. One out of six cell lines derived from HKBK cell-induced tumors showed the same characteristics as HKBK cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aaronson S. A., Todaro G. J. Infectious SV40 and SV40 DNA: rapid fluorescent focus assay. Proc Soc Exp Biol Med. 1970 May;134(1):103–106. doi: 10.3181/00379727-134-34738. [DOI] [PubMed] [Google Scholar]
  2. Barbanti-Brodano G., Possati L., La Placa M. Inactivation of polykaryocytogenic and hemolytic activities of Sendai virus by phospholipase B (lysolecithinase). J Virol. 1971 Nov;8(5):796–800. doi: 10.1128/jvi.8.5.796-800.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DIAMOND L. CELL TRANSFORMATION IN VITRO AND TUMOR INDUCTION IN VIVO BY LARGE- AND SMALL-PLAQUE POLYOMA VIRUS. Virology. 1964 May;23:73–80. doi: 10.1016/s0042-6822(64)80009-x. [DOI] [PubMed] [Google Scholar]
  4. Dougherty R. M., DiStefano H. S. Isolation and characterization of a papovavirus from human urine. Proc Soc Exp Biol Med. 1974 Jun;146(2):481–487. doi: 10.3181/00379727-146-38131. [DOI] [PubMed] [Google Scholar]
  5. Gardner S. D., Field A. M., Coleman D. V., Hulme B. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet. 1971 Jun 19;1(7712):1253–1257. doi: 10.1016/s0140-6736(71)91776-4. [DOI] [PubMed] [Google Scholar]
  6. Gardner S. D. Prevalence in England of antibody to human polyomavirus (B.k.). Br Med J. 1973 Jan 13;1(5845):77–78. doi: 10.1136/bmj.1.5845.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Huebner K., Croce C. M., Koprowski H. Isolation of defective viruses from SV40-transformed human and hamster cells. Virology. 1974 Jun;59(2):570–573. doi: 10.1016/0042-6822(74)90467-x. [DOI] [PubMed] [Google Scholar]
  8. Huebner K., Koprowski H. Synthesis of SV40 capsid antigen(s) in heterokaryocytes formed by fusion of nonpermissive with permissive cells. Virology. 1974 Apr;58(2):609–611. doi: 10.1016/0042-6822(74)90097-x. [DOI] [PubMed] [Google Scholar]
  9. Major E. O., Di Mayorca G. Malignant transformation of BHK21 clone 13 cells by BK virus--a human papovavirus. Proc Natl Acad Sci U S A. 1973 Nov;70(11):3210–3212. doi: 10.1073/pnas.70.11.3210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mullarkey M. F., Hruska J. F., Takemoto K. K. Comparison of two human papovaviruses with simian virus 40 by structural protein and antigenic analysis. J Virol. 1974 May;13(5):1014–1019. doi: 10.1128/jvi.13.5.1014-1019.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mäntyjärvi R. A., Arstila P. P., Meurman O. H. Hemagglutination by BK virus, a tentative new member of the papovavirus group. Infect Immun. 1972 Nov;6(5):824–828. doi: 10.1128/iai.6.5.824-828.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Padgett B. L., Walker D. L. Prevalence of antibodies in human sera against JC virus, an isolate from a case of progressive multifocal leukoencephalopathy. J Infect Dis. 1973 Apr;127(4):467–470. doi: 10.1093/infdis/127.4.467. [DOI] [PubMed] [Google Scholar]
  13. Penney J. B., Jr, Narayan O. Studies of the antigenic relationships of the new human papovaviruses by electron microscopy agglutination. Infect Immun. 1973 Aug;8(2):299–300. doi: 10.1128/iai.8.2.299-300.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Shah K. V., Daniel R. W., Murphy G. Antibodies reacting to Simian virus 40 T antigen in human sera. J Natl Cancer Inst. 1973 Aug;51(2):687–690. [PubMed] [Google Scholar]
  15. Shah K. V., Daniel R. W., Warszawski R. M. High prevalence of antibodies to BK virus, an SV40-related papovavirus, in residents of Maryland. J Infect Dis. 1973 Dec;128(6):784–787. doi: 10.1093/infdis/128.6.784. [DOI] [PubMed] [Google Scholar]
  16. Swetly P., Brodano G. B., Knowles B., Koprowski H. Response of simian virus 40-transformed cell lines and cell hybrids to superinfection with simian virus 40 and its deoxyribonucleic acid. J Virol. 1969 Oct;4(4):348–355. doi: 10.1128/jvi.4.4.348-355.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Takemoto K. K., Mullarkey M. F. Human papovavirus, BK strain: biological studies including antigenic relationship to simian virus 40. J Virol. 1973 Sep;12(3):625–631. doi: 10.1128/jvi.12.3.625-631.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]

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