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. 1975 Oct;16(4):767–774. doi: 10.1128/jvi.16.4.767-774.1975

Adenovirus type 2 DNA replication. II. Termini of DNA replication.

R Schilling, B Weingärtner, E L Winnacker
PMCID: PMC354734  PMID: 1165593

Abstract

Complete, mature adenovirus type 2 DNA molecules were isolated from virus-infected HeLa cells, pulse-labeled at 20 h postinfection in [3H]thymidine pulses shorter than the time necessary for one round of viral DNA replication. After digestion with the restriction endonucleases Eco RI, Hpa I, and Hind III, a temporal order of synthesis of different regions of the viral genome was established from the relative specific radioactivities in the restriction enzyme fragments. A comparison with the physical order of these fragments revealed the existence of two termini of DNA replication towards both the molecular right and left ends, respectively, of the viral chromosome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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