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. 1974 Jul;14(1):125–132. doi: 10.1128/jvi.14.1.125-132.1974

Immunological Properties of Two Polypeptides of Mason-Pfizer Monkey Virus

Steven R Tronick 1, John R Stephenson 1, Stuart A Aaronson 1
PMCID: PMC355485  PMID: 4134467

Abstract

Two polypeptides were isolated from the Mason-Pfizer monkey virus (MP-MV). The polypeptides, designated MP-MV p26 and MP-MV p15, were 26,000 and 15,000 molecular weight, respectively, based on gel filtration chromatography in the presence of 6 M guanidine hydrochloride. Radioimmunoassays developed for MP-MV p26 and p15 were, respectively, 10 and 100 times more sensitive than immunodiffusion and 1 and 10 times more sensitive than micro-complement fixation for the detection of MP-MV. Antigens of other reverse transcriptase-containing RNA viruses did not cross-react in either MP-MV radioimmunoassay. Further, antisera against these other viruses did not react with the radioiodine-labeled MP-MV polypeptides. The MP-MV radioimmunoassays should be useful in studying the natural occurrence of this virus and its relationship to primate tumors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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