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. 1972 Jan;9(1):110–115. doi: 10.1128/jvi.9.1.110-115.1972

Immunological Relationships of Reverse Transcriptases from Ribonucleic Acid Tumor Viruses

Wade P Parks 1, Edward M Scolnick 1, Jeffrey Ross 1, George J Todaro 1, Stuart A Aaronson 1
PMCID: PMC356269  PMID: 4333537

Abstract

Antiserum to partially purified reverse transcriptase from the Schmidt-Ruppin strain of Rous sarcoma virus has been prepared and characterized. Antibody to the avian polymerase inhibited the reverse transcriptase activity of avian C-type viruses but had no effect on the polymerase activity from C-type viruses of other classes. The known mammalian C-type viral polymerases were significantly inhibited only by the antiserum to murine C-type viral polymerases; reverse transcriptases from four other mammalian viruses were immunologically distinct from both avian and mammalian C-type viral polymerases. Partially purified murine leukemia viral DNA polymerase activity was comparably reduced by specific antibody regardless of the template used for enzyme detection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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