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. 1989 Jan;2(1):90–117. doi: 10.1128/cmr.2.1.90

Crohn's disease and the mycobacterioses: a review and comparison of two disease entities.

R J Chiodini 1
PMCID: PMC358101  PMID: 2644025

Abstract

Crohn's disease is a chronic granulomatous ileocolitis, of unknown etiology, which generally affects the patient during the prime of life. Medical treatment is supportive at best, and patients afflicted with this disorder generally live with chronic pain, in and out of hospitals, throughout their lives. The disease bears the name of the investigator who convincingly distinguished this disease from intestinal tuberculosis in 1932. This distinction was not universally accepted, and the notion of a mycobacterial etiology has never been fully dismissed. Nevertheless, it was 46 years after the distinction of Crohn's disease and intestinal tuberculosis before research attempting to reassociate mycobacteria and Crohn's disease was published. Recently, there has been a surge of interest in the possible association of mycobacteria and Crohn's disease due largely to the isolation of genetically identical pathogenic Mycobacterium paratuberculosis from several patients with Crohn's disease in the United States, the Netherlands, Australia, and France. These pathogenic organisms have been isolated from only a few patients, and direct evidence for their involvement in the disease process is not clear; however, M. paratuberculosis is an obligate intracellular organism and strict pathogen, which strongly suggests some etiologic role. Immunologic evidence of a mycobacterial etiology, as assessed by humoral immune determinations, has been conflicting, but evaluation of the more relevant cellular immunity has not been performed. Data from histochemical searches for mycobacteria in Crohn's disease tissues have been equally conflicting, with acid-fast bacilli detected in 0 to 35% of patients. Animal model studies have demonstrated the pathogenic potential of isolates as well as elucidated the complexity of mycobacterial-intestinal interactions. Treatment of Crohn's disease patients with antimycobacterial agent has not been fully assessed, although case reports suggest efficacy. The similarities in the pathology, epidemiology, and chemotherapy of Crohn's disease and the mycobacterioses are discussed. The issue is fraught with controversy, and the data generated on the association of mycobacteria and Crohn's disease are in their infantile stages so that a general conclusion on the legitimacy of this association cannot be made. While no firm evidence clearly implicates mycobacteria as an etiologic agent of Crohn's disease, the notion is supported by suggestive and circumstantial evidence and a remarkable similarity of Crohn's disease to known mycobacterial diseases.

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Selected References

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  1. ABRAMS J. S., HOLDEN W. D. TUBERCULOSIS OF THE GASTROINTESTINAL TRACT. Arch Surg. 1964 Aug;89:282–293. doi: 10.1001/archsurg.1964.01320020046008. [DOI] [PubMed] [Google Scholar]
  2. Abbas B., Riemann H. P., Lonnerdal B. Isolation of specific peptides from Mycobacterium paratuberculosis protoplasm and their use in an enzyme-linked immunosorbent assay for the detection of paratuberculosis (Johne's disease) in cattle. Am J Vet Res. 1983 Dec;44(12):2229–2236. [PubMed] [Google Scholar]
  3. Abou-Zeid C., Harboe M., Sundsten B., Cocito C. Cross-reactivity of antigens from the cytoplasm and cell walls of some corynebacteria and mycobacteria. J Infect Dis. 1985 Jan;151(1):170–178. doi: 10.1093/infdis/151.1.170. [DOI] [PubMed] [Google Scholar]
  4. Ahlberg J., Bergstrand O., Gillström P., Holmström B., Kronevi T., Reiland S. Negative findings in search for a transmissible agent in Crohn's disease. Acta Chir Scand Suppl. 1978;482:45–47. [PubMed] [Google Scholar]
  5. Ahn C. H., Ahn S. S., Anderson R. A., Murphy D. T., Mammo A. A four-drug regimen for initial treatment of cavitary disease caused by Mycobacterium avium complex. Am Rev Respir Dis. 1986 Sep;134(3):438–441. doi: 10.1164/arrd.1986.134.3.438. [DOI] [PubMed] [Google Scholar]
  6. Allinquant B., Malfoy B., Schuller E., Leng M. Presence of Z-DNA specific antibodies in Crohn's disease, polyradiculoneuritis and amyotrophic lateral sclerosis. Clin Exp Immunol. 1984 Oct;58(1):29–36. [PMC free article] [PubMed] [Google Scholar]
  7. Angus K. W., Gilmour N. J. Effect of the rimino phenazine B663 (G30320) on Mycobacterium johnei infection and reinfection in sheep. II. Pathology. J Comp Pathol. 1971 Apr;81(2):227–234. doi: 10.1016/0021-9975(71)90096-x. [DOI] [PubMed] [Google Scholar]
  8. Auer I. O., Röder A., Wensinck F., van de Merwe J. P., Schmidt H. Selected bacterial antibodies in Crohn's disease and ulcerative colitis. Scand J Gastroenterol. 1983 Mar;18(2):217–223. doi: 10.3109/00365528309181586. [DOI] [PubMed] [Google Scholar]
  9. Azadkhan A. K., Truelove S. C., Aronson J. K. The disposition and metabolism of sulphasalazine (salicylazosulphapyridine) in man. Br J Clin Pharmacol. 1982 Apr;13(4):523–528. doi: 10.1111/j.1365-2125.1982.tb01415.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Bagchi S., Das K. M. Detection and partial characterization of Crohn's disease tissue specific proteins recognized by Crohn's disease sera. Clin Exp Immunol. 1984 Jan;55(1):41–48. [PMC free article] [PubMed] [Google Scholar]
  11. Bass J. B., Jr Mycobacterium avium-intracellulare--rational therapy of chronic pulmonary infection? Am Rev Respir Dis. 1986 Sep;134(3):431–432. doi: 10.1164/arrd.1986.134.3.431. [DOI] [PubMed] [Google Scholar]
  12. Beeken W. L., Macpherson B. R., Gundel R. M., St Andre-Ukena S., Wood S. G., Sylwester D. L. Depressed spontaneous cell-mediated cytotoxicity in Crohn's disease. Clin Exp Immunol. 1983 Feb;51(2):351–358. [PMC free article] [PubMed] [Google Scholar]
  13. Beeken W. L., St Andre-Ukena S., Gundel R. M. Comparative studies of mononuclear phagocyte function in patients with Crohn's disease and colon neoplasms. Gut. 1983 Nov;24(11):1034–1040. doi: 10.1136/gut.24.11.1034. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Beitman R. G., Frost S. S., Roth J. L. Oral manifestations of gastrointestinal disease. Dig Dis Sci. 1981 Aug;26(8):741–747. doi: 10.1007/BF01316865. [DOI] [PubMed] [Google Scholar]
  15. Bekierkunst A., Levij I. S., Yarkoni E., Vilkas E., Adam A., Lederer E. Granuloma formation induced in mice by chemically defined mycobacterial fractions. J Bacteriol. 1969 Oct;100(1):95–102. doi: 10.1128/jb.100.1.95-102.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Belsheim M. R., Darwish R. Z., Watson W. C., Schieven B. Bacterial L-form isolation from inflammatory bowel disease patients. Gastroenterology. 1983 Aug;85(2):364–369. [PubMed] [Google Scholar]
  17. Bentley G., Webster J. H. Gastro-intestinal tuberculosis. A 10-year review. Br J Surg. 1967 Feb;54(2):90–96. doi: 10.1002/bjs.1800540203. [DOI] [PubMed] [Google Scholar]
  18. Berg N. O., Dencker H. Crohn's disease in monozygotic twins. Acta Chir Scand. 1972;138(6):633–635. [PubMed] [Google Scholar]
  19. Bhargava D. K., Chawla T. C., Tandon B. N., Shriniwas, Kapur B. M., Tandon H. D. Cell mediated immune response in intestinal tuberculosis. Indian J Med Res. 1984 Sep;80:264–269. [PubMed] [Google Scholar]
  20. Bird A. G., Britton S. No evidence for decreased lymphocyte reactivity in Crohn's disease. Gastroenterology. 1974 Nov;67(5):926–932. [PubMed] [Google Scholar]
  21. Bjarnason I., Zanelli G., Smith T., Prouse P., Williams P., Smethurst P., Delacey G., Gumpel M. J., Levi A. J. Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans. Gastroenterology. 1987 Sep;93(3):480–489. doi: 10.1016/0016-5085(87)90909-7. [DOI] [PubMed] [Google Scholar]
  22. Blaser M. J., Miller R. A., Lacher J., Singleton J. W. Patients with active Crohn's disease have elevated serum antibodies to antigens of seven enteric bacterial pathogens. Gastroenterology. 1984 Oct;87(4):888–894. [PubMed] [Google Scholar]
  23. Bolton P. M., Owen E., Heatley R. V., Williams W. J., Hughes L. E. Negative findings in laboratory animals for a transmissible agent in Crohn's disease. Lancet. 1973 Nov 17;2(7838):1122–1124. doi: 10.1016/s0140-6736(73)90937-9. [DOI] [PubMed] [Google Scholar]
  24. Brewerton D. A. Crohn's disease and arthritis. J R Soc Med. 1981 Jul;74(7):478–479. doi: 10.1177/014107688107400703. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Brooks R. W., Parker B. C., Gruft H., Falkinham J. O., 3rd Epidemiology of infection by nontuberculous mycobacteria. V. Numbers in eastern United States soils and correlation with soil characteristics. Am Rev Respir Dis. 1984 Oct;130(4):630–633. doi: 10.1164/arrd.1984.130.4.630. [DOI] [PubMed] [Google Scholar]
  26. Brown T. E., Bankhurst A. D., Strickland R. G. Natural killer cell function and lymphocyte subpopulation profiles in inflammatory bowel disease. J Clin Lab Immunol. 1983 Jul;11(3):113–117. [PubMed] [Google Scholar]
  27. Brown T. H. The rapidly growing mycobacteria--Mycobacterium fortuitum and Mycobacterium chelonei. Infect Control. 1985 Jul;6(7):283–288. doi: 10.1017/s0195941700061762. [DOI] [PubMed] [Google Scholar]
  28. Buergelt C. D., Hall C., McEntee K., Duncan J. R. Pathological evaluation of paratuberculosis in naturally infected cattle. Vet Pathol. 1978 Mar;15(2):196–207. doi: 10.1177/030098587801500206. [DOI] [PubMed] [Google Scholar]
  29. Burnham W. R., Lennard-Jones J. E., Stanford J. L., Bird R. G. Mycobacteria as a possible cause of inflammatory bowel disease. Lancet. 1978 Sep 30;2(8092 Pt 1):693–696. doi: 10.1016/s0140-6736(78)92699-5. [DOI] [PubMed] [Google Scholar]
  30. Calkins B. M., Lilienfeld A. M., Garland C. F., Mendeloff A. I. Trends in incidence rates of ulcerative colitis and Crohn's disease. Dig Dis Sci. 1984 Oct;29(10):913–920. doi: 10.1007/BF01312480. [DOI] [PubMed] [Google Scholar]
  31. Calkins B. M., Mendeloff A. I. Epidemiology of inflammatory bowel disease. Epidemiol Rev. 1986;8:60–91. doi: 10.1093/oxfordjournals.epirev.a036296. [DOI] [PubMed] [Google Scholar]
  32. Camphausen R. T., Jones R. L., Brennan P. J. A glycolipid antigen specific to Mycobacterium paratuberculosis: structure and antigenicity. Proc Natl Acad Sci U S A. 1985 May;82(10):3068–3072. doi: 10.1073/pnas.82.10.3068. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Camphausen R. T., Jones R. L., Brennan P. J. Structure and relevance of the oligosaccharide hapten of Mycobacterium avium serotype 2. J Bacteriol. 1986 Nov;168(2):660–667. doi: 10.1128/jb.168.2.660-667.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Carrera G. F., Young S., Lewicki A. M. Intestinal tuberculosis. Gastrointest Radiol. 1976;1(2):147–155. doi: 10.1007/BF02256357. [DOI] [PubMed] [Google Scholar]
  35. Cave D. R., Mitchell D. N., Brooke B. N. Induction of granulomas in mice by Crohn's disease tissue. Gastroenterology. 1978 Oct;75(4):632–637. [PubMed] [Google Scholar]
  36. Cave D. R., Mitchell D. N., Kane S. P., Brooke B. N. Further animal evidence of a transmissible agent in Crohn's disease. Lancet. 1973 Nov 17;2(7838):1120–1122. doi: 10.1016/s0140-6736(73)90936-7. [DOI] [PubMed] [Google Scholar]
  37. Chaparas S. D. Immunity in tuberculosis. Bull World Health Organ. 1982;60(4):447–462. [PMC free article] [PubMed] [Google Scholar]
  38. Chaparas S. D. The immunology of mycobacterial infections. Crit Rev Microbiol. 1982;9(2):139–197. doi: 10.3109/10408418209104488. [DOI] [PubMed] [Google Scholar]
  39. Chiewsilp P., Petchclai B., Chirachariyavej T., Ramasoota T. Immunoglobulins in leprosy. Int J Lepr Other Mycobact Dis. 1985 Mar;53(1):28–32. [PubMed] [Google Scholar]
  40. Chiodini R. J. Biochemical characteristics of various strains of Mycobacterium paratuberculosis. Am J Vet Res. 1986 Jul;47(7):1442–1445. [PubMed] [Google Scholar]
  41. Chiodini R. J., Van Kruiningen H. J. Characterization of Mycobacterium paratuberculosis of bovine, caprine, and ovine origin by gas-liquid chromatographic analysis of fatty acids in whole-cell extracts. Am J Vet Res. 1985 Sep;46(9):1980–1989. [PubMed] [Google Scholar]
  42. Chiodini R. J., Van Kruiningen H. J., Merkal R. S. Ruminant paratuberculosis (Johne's disease): the current status and future prospects. Cornell Vet. 1984 Jul;74(3):218–262. [PubMed] [Google Scholar]
  43. Chiodini R. J., Van Kruiningen H. J., Merkal R. S., Thayer W. R., Jr, Coutu J. A. Characteristics of an unclassified Mycobacterium species isolated from patients with Crohn's disease. J Clin Microbiol. 1984 Nov;20(5):966–971. doi: 10.1128/jcm.20.5.966-971.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Chiodini R. J., Van Kruiningen H. J., Thayer W. R., Coutu J. A., Merkal R. S. In vitro antimicrobial susceptibility of a Mycobacterium sp. isolated from patients with Crohn's disease. Antimicrob Agents Chemother. 1984 Dec;26(6):930–932. doi: 10.1128/aac.26.6.930. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Chiodini R. J., Van Kruiningen H. J., Thayer W. R., Coutu J. A. Spheroplastic phase of mycobacteria isolated from patients with Crohn's disease. J Clin Microbiol. 1986 Sep;24(3):357–363. doi: 10.1128/jcm.24.3.357-363.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Chiodini R. J., Van Kruiningen H. J., Thayer W. R., Merkal R. S., Coutu J. A. Possible role of mycobacteria in inflammatory bowel disease. I. An unclassified Mycobacterium species isolated from patients with Crohn's disease. Dig Dis Sci. 1984 Dec;29(12):1073–1079. doi: 10.1007/BF01317078. [DOI] [PubMed] [Google Scholar]
  47. Chiodini R. J., van Kruiningen H. J. The prevalence of paratuberculosis in culled New England cattle. Cornell Vet. 1986 Jan;76(1):91–104. [PubMed] [Google Scholar]
  48. Cho S. N., Brennan P. J., Yoshimura H. H., Korelitz B. I., Graham D. Y. Mycobacterial aetiology of Crohn's disease: serologic study using common mycobacterial antigens and a species-specific glycolipid antigen from Mycobacterium paratuberculosis. Gut. 1986 Nov;27(11):1353–1356. doi: 10.1136/gut.27.11.1353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Cocito C., Abou-Zeid C., Danhaive P., Fontaine F., Gailly C., Gueur M. C., Janczura E., Delville J. Biochemical studies with leprosy-derived corynebacteria. Acta Leprol. 1982 Jul-Sep;(88):33–46. [PubMed] [Google Scholar]
  50. Daniel T. M. Circulating immune complexes in tuberculosis. Am Rev Respir Dis. 1986 Aug;134(2):199–200. doi: 10.1164/arrd.1986.134.2.199. [DOI] [PubMed] [Google Scholar]
  51. Daniel T. M., Janicki B. W. Mycobacterial antigens: a review of their isolation, chemistry, and immunological properties. Microbiol Rev. 1978 Mar;42(1):84–113. doi: 10.1128/mr.42.1.84-113.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Danis V. A., Harries A. D., Heatley R. V. Antigen-antibody complexes in inflammatory bowel disease. Scand J Gastroenterol. 1984 Jul;19(5):603–606. [PubMed] [Google Scholar]
  53. Danzi J. T. Extraintestinal manifestations of idiopathic inflammatory bowel disease. Arch Intern Med. 1988 Feb;148(2):297–302. [PubMed] [Google Scholar]
  54. Das K. M., Valenzuela I., Morecki R. Crohn disease lymph node homogenates produce murine lymphoma in athymic mice. Proc Natl Acad Sci U S A. 1980 Jan;77(1):588–592. doi: 10.1073/pnas.77.1.588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Date A., Harihar S., Jeyavarthini S. E. Renal lesions and other major findings in necropsies of 133 patients with leprosy. Int J Lepr Other Mycobact Dis. 1985 Sep;53(3):455–460. [PubMed] [Google Scholar]
  56. De Dombal F. T., Burton I., Goligher J. C. Recurrence of Crohn's disease after primary excisional surgery. Gut. 1971 Jul;12(7):519–527. doi: 10.1136/gut.12.7.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Dhople A. M., Kazda J., Green K. J., Storrs E. E. Presence of "difficult to isolate" mycobacteria in armadillos. Indian J Lepr. 1986 Jan-Mar;58(1):29–37. [PubMed] [Google Scholar]
  58. Doldi K., Manger B., Koch B., Riemann J., Hermanek P., Kalden J. R. Spontaneous suppressor cell activity in the peripheral blood of patients with malignant and chronic inflammatory bowel diseases. Clin Exp Immunol. 1984 Mar;55(3):655–663. [PMC free article] [PubMed] [Google Scholar]
  59. Draper P. The bacteriology of Mycobacterium leprae. Tubercle. 1983 Mar;64(1):43–56. doi: 10.1016/0041-3879(83)90050-8. [DOI] [PubMed] [Google Scholar]
  60. Ebert E. C., Wright S. H., Lipshutz W. H., Hauptman S. P. T-cell abnormalities in inflammatory bowel disease are mediated by interleukin 2. Clin Immunol Immunopathol. 1984 Nov;33(2):232–244. doi: 10.1016/0090-1229(84)90078-3. [DOI] [PubMed] [Google Scholar]
  61. Edwards P. Q. Tuberculin negative? N Engl J Med. 1972 Feb 17;286(7):373–374. doi: 10.1056/NEJM197202172860712. [DOI] [PubMed] [Google Scholar]
  62. Elliott P. R., Lennard-Jones J. E., Burnham W. R., White S., Stanford J. L. Further data on skin testing with mycobacterial antigens in inflammatory bowel disease. Lancet. 1980 Aug 30;2(8192):483–484. doi: 10.1016/s0140-6736(80)91922-4. [DOI] [PubMed] [Google Scholar]
  63. Elson C. O., Graeff A. S., James S. P., Strober W. Covert suppressor T cells in Crohn's disease. Gastroenterology. 1981 Jun;80(6):1513–1521. [PubMed] [Google Scholar]
  64. Elson C. O., James S. P., Graeff A. S., Berendson R. A., Strober W. Hypogammaglobulinemia due to abnormal suppressor T-cell activity in Crohn's disease. Gastroenterology. 1984 Mar;86(3):569–576. [PubMed] [Google Scholar]
  65. Eustis-Turf E. P., Benjamins J. A., Lefford M. J. Characterization of the anti-neural antibodies in the sera of leprosy patients. J Neuroimmunol. 1986 Feb;10(4):313–330. doi: 10.1016/S0165-5728(86)90015-9. [DOI] [PubMed] [Google Scholar]
  66. Fais S., Pallone F., Squarcia O., Boirivant M., Pozzilli P. T cell early activation antigens expressed by peripheral lymphocytes in Crohn's disease. J Clin Lab Immunol. 1985 Feb;16(2):75–76. [PubMed] [Google Scholar]
  67. Farmer R. G., Michener W. M., Mortimer E. A. Studies of family history among patients with inflammatory bowel disease. Clin Gastroenterol. 1980 May;9(2):271–277. [PubMed] [Google Scholar]
  68. Farmer R. G., Whelan G., Fazio V. W. Long-term follow-up of patients with Crohn's disease. Relationship between the clinical pattern and prognosis. Gastroenterology. 1985 Jun;88(6):1818–1825. doi: 10.1016/0016-5085(85)90006-x. [DOI] [PubMed] [Google Scholar]
  69. Fielding J. F. The relative risk of inflammatory bowel disease among parents and siblings of Crohn's disease patients. J Clin Gastroenterol. 1986 Dec;8(6):655–657. doi: 10.1097/00004836-198612000-00013. [DOI] [PubMed] [Google Scholar]
  70. Fiocchi C., Battisto J. R., Farmer R. G. Studies on isolated gut mucosal lymphocytes in inflammatory bowel disease. Detection of activated T cells and enhanced proliferation to Staphylococcus aureus and lipopolysaccharides. Dig Dis Sci. 1981 Aug;26(8):728–736. doi: 10.1007/BF01316863. [DOI] [PubMed] [Google Scholar]
  71. Fiocchi C., Youngman K. R., Farmer R. G. Immunoregulatory function of human intestinal mucosa lymphoid cells: evidence for enhanced suppressor cell activity in inflammatory bowel disease. Gut. 1983 Aug;24(8):692–701. doi: 10.1136/gut.24.8.692. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Fujita K., Naito S., Okabe N., Yao T. Immunological studies in Crohn's disease. I. Association with HLA systems in the Japanese. J Clin Lab Immunol. 1984 Jun;14(2):99–102. [PubMed] [Google Scholar]
  73. Furukawa F., Sekita K., Hamashima Y., Ozaki M., Imamura S. Evaluation of circulating immune complexes and antinuclear antibodies in Japanese patients with leprosy. Arch Dermatol Res. 1983;275(3):144–146. doi: 10.1007/BF00510043. [DOI] [PubMed] [Google Scholar]
  74. George K. L., Parker B. C., Gruft H., Falkinham J. O., 3rd Epidemiology of infection by nontuberculous mycobacteria. II. Growth and survival in natural waters. Am Rev Respir Dis. 1980 Jul;122(1):89–94. doi: 10.1164/arrd.1980.122.1.89. [DOI] [PubMed] [Google Scholar]
  75. Gilat T. Incidence of inflammatory bowel disease: going up or down? Gastroenterology. 1983 Jul;85(1):196–197. [PubMed] [Google Scholar]
  76. Gilmour N. J., Angus K. W. Effect of the rimino phenazine B663 (G30320) on Mycobacterium johnei infection and reinfection in sheep. I. Bacteriology and hypersensitivity. J Comp Pathol. 1971 Apr;81(2):221–226. doi: 10.1016/0021-9975(71)90095-8. [DOI] [PubMed] [Google Scholar]
  77. Gilmour N. J., Goudswaard J. Corynebacterium renale as a cause of reactions to the complement fixation test for Johne's disease. J Comp Pathol. 1972 Jul;82(3):333–336. doi: 10.1016/0021-9975(72)90014-x. [DOI] [PubMed] [Google Scholar]
  78. Gitnick G. L., Rosen V. J., Arthur M. H., Hertweck S. A. Evidence for the isolation of a new virus from ulcerative colitis patients. Comparison with virus derived from Crohn's disease. Dig Dis Sci. 1979 Aug;24(8):609–619. doi: 10.1007/BF01333705. [DOI] [PubMed] [Google Scholar]
  79. Gitnick G. Is Crohn's disease a mycobacterial disease after all? Dig Dis Sci. 1984 Dec;29(12):1086–1088. doi: 10.1007/BF01317080. [DOI] [PubMed] [Google Scholar]
  80. Glassman M., Kaplan M., Spivak W. Immune-complex glomerulonephritis in Crohn's disease. J Pediatr Gastroenterol Nutr. 1986 Nov-Dec;5(6):966–969. doi: 10.1097/00005176-198611000-00026. [DOI] [PubMed] [Google Scholar]
  81. Godin N. J., Sachar D. B., Winchester R., Simon C., Janowitz H. D. Loss of suppressor T-cells in active inflammatory bowel disease. Gut. 1984 Jul;25(7):743–747. doi: 10.1136/gut.25.7.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  82. Golde D. W. Aetiology of regional enteritis. Lancet. 1968 May 25;1(7552):1144–1145. doi: 10.1016/s0140-6736(68)90202-x. [DOI] [PubMed] [Google Scholar]
  83. Goligher J. C., de Dombal F. T., Burton I. Crohn's disease, with special reference to surgical management. Prog Surg. 1972;10:1–23. doi: 10.1159/000392833. [DOI] [PubMed] [Google Scholar]
  84. Goodacre R. L., Bienenstock J. Reduced suppressor cell activity in intestinal lymphocytes from patients with Crohn's disease. Gastroenterology. 1982 Apr;82(4):653–658. [PubMed] [Google Scholar]
  85. Gorse G. J., Fairshter R. D., Friedly G., Dela Maza L., Greene G. R., Cesario T. C. Nontuberculous mycobacterial disease. Experience in a southern California hospital. Arch Intern Med. 1983 Feb;143(2):225–228. doi: 10.1001/archinte.143.2.225. [DOI] [PubMed] [Google Scholar]
  86. Graham D. Y., Markesich D. C., Yoshimura H. H. Mycobacteria and inflammatory bowel disease. Results of culture. Gastroenterology. 1987 Feb;92(2):436–442. doi: 10.1016/0016-5085(87)90139-9. [DOI] [PubMed] [Google Scholar]
  87. Grange J. M., Gibson J., Nassau E., Kardjito T. Enzyme-linked immunosorbent assay (ELISA): a study of antibodies to Mycobacterium tuberculosis in the IgG, IgA and IgM classes in tuberculosis, sarcoidosis and Crohn's disease. Tubercle. 1980 Sep;61(3):145–152. doi: 10.1016/0041-3879(80)90003-3. [DOI] [PubMed] [Google Scholar]
  88. Greenberg H. B., Gebhard R. L., McClain C. J., Soltis R. D., Kapikian A. Z. Antibodies to viral gastroenteritis viruses in Crohn's disease. Gastroenterology. 1979 Feb;76(2):349–350. [PubMed] [Google Scholar]
  89. Greenstein A. J., Sachar D. B., Pasternack B. S., Janowitz H. D. Reoperation and recurrence in Crohn's colitis and ileocolitis Crude and cumulative rates. N Engl J Med. 1975 Oct 2;293(14):685–690. doi: 10.1056/NEJM197510022931403. [DOI] [PubMed] [Google Scholar]
  90. Gremillion D. H., Mursch S. B., Lerner C. J. Injection site abscesses caused by Mycobacterium chelonei. Infect Control. 1983 Jan-Feb;4(1):25–28. doi: 10.1017/s019594170005760x. [DOI] [PubMed] [Google Scholar]
  91. Gruft H., Falkinham J. O., 3rd, Parker B. C. Recent experience in the epidemiology of disease caused by atypical mycobacteria. Rev Infect Dis. 1981 Sep-Oct;3(5):990–996. doi: 10.1093/clinids/3.5.990. [DOI] [PubMed] [Google Scholar]
  92. HOON J. R., DOCKERTY M. B., PEMBERTON J. de J. Ileocecal tuberculosis including a comparison of this disease with nonspecific regional enterocolitis and noncaseous tuberculated enterocolitis. Int Abstr Surg. 1950 Nov;91(5):417–440. [PubMed] [Google Scholar]
  93. HOWELL J. S., KNAPTON P. J. ILEO-CAECAL TUBERCULOSIS. Gut. 1964 Dec;5:524–529. doi: 10.1136/gut.5.6.524. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Haanaes O. C., Bergmann A. Tuberculosis emerging in patients treated with corticosteroids. Eur J Respir Dis. 1983 May;64(4):294–297. [PubMed] [Google Scholar]
  95. Haga Y. [Mycobacteria in Crohn's disease]. Nihon Shokakibyo Gakkai Zasshi. 1986 Nov;83(11):2325–2333. [PubMed] [Google Scholar]
  96. Hannuksela M. Erythema nodosum. Clin Dermatol. 1986 Oct-Dec;4(4):88–95. doi: 10.1016/0738-081x(86)90037-4. [DOI] [PubMed] [Google Scholar]
  97. Harper P. H., Fazio V. W., Lavery I. C., Jagelman D. G., Weakley F. L., Farmer R. G., Easley K. A. The long-term outcome in Crohn's disease. Dis Colon Rectum. 1987 Mar;30(3):174–179. doi: 10.1007/BF02554332. [DOI] [PubMed] [Google Scholar]
  98. Hattikudur S., Kamat R. S. Polymorphism of a mycobacterial antigen participating in cell-mediated immunity. J Med Microbiol. 1985 Feb;19(1):69–75. doi: 10.1099/00222615-19-1-69. [DOI] [PubMed] [Google Scholar]
  99. Havelaar A. H., Berwald L. G., Groothuis D. G., Baas J. G. Mycobacteria in semi-public swimming-pools and whirlpools. Zentralbl Bakteriol Mikrobiol Hyg B. 1985 May;180(5-6):505–514. [PubMed] [Google Scholar]
  100. Heimann T. M., Aufses A. H., Jr The role of peripheral lymphocytes in the prediction of recurrence in Crohn's disease. Surg Gynecol Obstet. 1985 Apr;160(4):295–298. [PubMed] [Google Scholar]
  101. Higgens C. S., Allan R. N. Crohn's disease of the distal ileum. Gut. 1980 Nov;21(11):933–940. doi: 10.1136/gut.21.11.933. [DOI] [PMC free article] [PubMed] [Google Scholar]
  102. Hodder R. V., Le Saux N., Shamji F. M., Kronick S. H. Tuberculosis presenting as stridor. Ann Thorac Surg. 1987 Jan;43(1):98–99. doi: 10.1016/s0003-4975(10)60175-0. [DOI] [PubMed] [Google Scholar]
  103. Holla V. V., Kenetkar M. V., Kolhatkar M. K., Kulkarin C. N. Leprous synovitis. A study of fifty cases. Int J Lepr Other Mycobact Dis. 1983 Mar;51(1):29–32. [PubMed] [Google Scholar]
  104. Holoshitz J., Matitiau A., Cohen I. R. Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II. J Clin Invest. 1984 Jan;73(1):211–215. doi: 10.1172/JCI111193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  105. Hornick D. B., Dayton C. S., Bedell G. N., Fick R. B., Jr Nontuberculous mycobacterial lung disease. Substantiation of a less aggressive approach. Chest. 1988 Mar;93(3):550–555. doi: 10.1378/chest.93.3.550. [DOI] [PubMed] [Google Scholar]
  106. Horsburgh C. R., Jr, Mason U. G., 3rd, Heifets L. B., Southwick K., Labrecque J., Iseman M. D. Response to therapy of pulmonary Mycobacterium avium-intracellulare infection correlates with results of in vitro susceptibility testing. Am Rev Respir Dis. 1987 Feb;135(2):418–421. doi: 10.1164/arrd.1987.135.2.418. [DOI] [PubMed] [Google Scholar]
  107. Iliffe G. D., Owen D. A. Rectal biopsy in Crohn's disease. Dig Dis Sci. 1981 Apr;26(4):321–324. doi: 10.1007/BF01308372. [DOI] [PubMed] [Google Scholar]
  108. Imkamp F. M. Standardized schemes for steroid treatment in ENL and reversal reactions. Int J Lepr Other Mycobact Dis. 1985 Jun;53(2):313–317. [PubMed] [Google Scholar]
  109. James S. P., Fiocchi C., Graeff A. S., Strober W. Immunoregulatory function of lamina propria T cells in Crohn's disease. Gastroenterology. 1985 May;88(5 Pt 1):1143–1150. doi: 10.1016/s0016-5085(85)80073-1. [DOI] [PubMed] [Google Scholar]
  110. Janczura E., Abou-Zeid C., Gailly C., Cocito C. Chemical identification of some cell-wall components of microorganisms isolated from human leprosy lesions. Zentralbl Bakteriol Mikrobiol Hyg A. 1981 Dec;251(1):114–125. [PubMed] [Google Scholar]
  111. Jarnagin J. L., Himes E. M., Richards W. D., Luchsinger D. W., Harrington R., Jr Isolation of Mycobacterium kansasii from lymph nodes of cattle in the United States. Am J Vet Res. 1983 Oct;44(10):1853–1855. [PubMed] [Google Scholar]
  112. Jin B. W., Saito H., Yoshii Z. Environmental mycobacteria in Korea. I. Distribution of the organisms. Microbiol Immunol. 1984;28(6):667–677. doi: 10.1111/j.1348-0421.1984.tb00721.x. [DOI] [PubMed] [Google Scholar]
  113. KIRSNER J. B., SPENCER J. A. FAMILY OCCURRENCES OF ULCERATIVE COLITIS, REGIONAL ENTERITIS, AND ILEOCOLITIS. Ann Intern Med. 1963 Aug;59:133–144. doi: 10.7326/0003-4819-59-2-133. [DOI] [PubMed] [Google Scholar]
  114. Kapikian A. Z., Barile M. F., Wyatt R. G., Yolken R. H., Tully J. G., Greenberg H. B., Kalica A. R., Chanock R. M. Mycoplasma contamination in cell culture of Crohn's disease material. Lancet. 1979 Sep 1;2(8140):466–467. doi: 10.1016/s0140-6736(79)91516-2. [DOI] [PubMed] [Google Scholar]
  115. Kaufmann H. J., Taubin H. L. Nonsteroidal anti-inflammatory drugs activate quiescent inflammatory bowel disease. Ann Intern Med. 1987 Oct;107(4):513–516. doi: 10.7326/0003-4819-107-4-513. [DOI] [PubMed] [Google Scholar]
  116. Kelly J. H., Montgomery W. W., Goodman M. L., Mulvaney T. J. Upper airway obstruction associated with regional enteritis. Ann Otol Rhinol Laryngol. 1979 Jan-Feb;88(1 Pt 1):95–99. doi: 10.1177/000348947908800116. [DOI] [PubMed] [Google Scholar]
  117. Kirsner J. B. Landmark perspective. Crohn's disease. JAMA. 1984 Jan 6;251(1):80–81. doi: 10.1001/jama.251.1.80. [DOI] [PubMed] [Google Scholar]
  118. Kirsner J. B. The idiopathic' inflammatory bowel diseases: their cause and pathogenesis. Arch Dermatol. 1982 Apr;118(4):280–282. [PubMed] [Google Scholar]
  119. Klein G. L., Ament M. E., Sparkes R. S. Monozygotic twins with Crohn's disease: a case report. Gastroenterology. 1980 Nov;79(5 Pt 1):931–933. [PubMed] [Google Scholar]
  120. Kluge J. P., Merkal R. S., Monlux W. S., Larsen A. B., Kopecky K. E., Ramsey F. K., Lehmann R. P. Experimental paratuberculosis in sheep after oral, intratracheal, or intravenous inoculation lesions and demonstration of etiologic agent. Am J Vet Res. 1968 May;29(5):953–962. [PubMed] [Google Scholar]
  121. Kobayashi K., Brown W. R., Brennan P. J., Blaser M. J. Serum antibodies to mycobacterial antigens in active Crohn's disease. Gastroenterology. 1988 Jun;94(6):1404–1411. doi: 10.1016/0016-5085(88)90679-8. [DOI] [PubMed] [Google Scholar]
  122. Konttinen Y. T., Bergroth V., Nordström D., Segerberg-Konttinen M., Seppälä K., Salaspuro M. Lymphocyte activation in vivo in the intestinal mucosa of patients with Crohn's disease. J Clin Lab Immunol. 1987 Feb;22(2):59–63. [PubMed] [Google Scholar]
  123. Kopecky K. E., Larsen A. B., Merkal R. S. Uterine infection in bovine paratuberculosis. Am J Vet Res. 1967 Jul;28(125):1043–1045. [PubMed] [Google Scholar]
  124. Kozarek R. A. Extracolonic manifestations of inflammatory bowel disease. Am Fam Physician. 1987 Feb;35(2):205–211. [PubMed] [Google Scholar]
  125. Krc I., Kojecky Z., Matousková I., Benysek L. Crohn's disease, serum immunodepressive factors and circulating immune complexes. Boll Ist Sieroter Milan. 1980;59(6):619–624. [PubMed] [Google Scholar]
  126. Kruis W., Schussler P., Weinzierl M., Galanos C., Eisenburg J. Circulating lipid A antibodies despite absence of systemic endotoxemia in patients with Crohn's disease. Dig Dis Sci. 1984 Jun;29(6):502–507. doi: 10.1007/BF01296269. [DOI] [PubMed] [Google Scholar]
  127. Kulkarni S., Hattikudur S., Kamat R. S. Cell mediated immunity cross-reactions of mycobacteria: polymorphism of target bacterial antigens. Clin Exp Immunol. 1986 Jan;63(1):111–117. [PMC free article] [PubMed] [Google Scholar]
  128. Kulkarni S., Kamat R. S. Cross-reactions in cell mediated immunity induced by atypical mycobacteria. J Med Microbiol. 1986 Feb;21(1):35–38. doi: 10.1099/00222615-21-1-35. [DOI] [PubMed] [Google Scholar]
  129. Kuspira J., Bhambhani R., Singh S. M., Links H. Familial occurrence of Crohn's disease. Hum Hered. 1972;22(3):239–242. doi: 10.1159/000152492. [DOI] [PubMed] [Google Scholar]
  130. LOCKHART-MUMMERY H. E., MORSON B. C. Crohn's disease (regional enteritis) of the large intestine and its distinction from ulcerative colitis. Gut. 1960 Jun;1:87–105. doi: 10.1136/gut.1.2.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  131. Lagrange P. H., Hurtrel B., Brandely M., Thickstun P. M. Immunological mechanisms controlling mycobacterial infections. Bull Eur Physiopathol Respir. 1983 Mar-Apr;19(2):163–172. [PubMed] [Google Scholar]
  132. Laughlin J. A., Harris S. C., Fine R., Collins J. F. Lung injury induced by mycobacterial cell walls: effects on connective tissue. Exp Mol Pathol. 1981 Dec;35(3):380–387. doi: 10.1016/0014-4800(81)90021-6. [DOI] [PubMed] [Google Scholar]
  133. Lefford M. J., Morgan R., Logie P. S. Effect of Mycobacterium bovis BCG vaccination upon Mycobacterium lepraemurium infection. Infect Immun. 1980 Jun;28(3):860–866. doi: 10.1128/iai.28.3.860-866.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  134. Lock M. R., Farmer R. G., Fazio V. W., Jagelman D. G., Lavery I. C., Weakley F. L. Recurrence and reoperation for Crohn's disease: the role of disease location in prognosis. N Engl J Med. 1981 Jun 25;304(26):1586–1588. doi: 10.1056/NEJM198106253042607. [DOI] [PubMed] [Google Scholar]
  135. MacDermott R. P., Bragdon M. J., Thurmond R. D. Peripheral blood mononuclear cells from patients with inflammatory bowel disease exhibit normal function in the allogeneic and autologous mixed leukocyte reaction and cell-mediated lympholysis. Gastroenterology. 1984 Mar;86(3):476–484. [PubMed] [Google Scholar]
  136. MacDermott R. P., Nash G. S., Bertovich M. J., Seiden M. V., Bragdon M. J., Beale M. G. Alterations of IgM, IgG, and IgA Synthesis and secretion by peripheral blood and intestinal mononuclear cells from patients with ulcerative colitis and Crohn's disease. Gastroenterology. 1981 Nov;81(5):844–852. [PubMed] [Google Scholar]
  137. Malchow H., Ewe K., Brandes J. W., Goebell H., Ehms H., Sommer H., Jesdinsky H. European Cooperative Crohn's Disease Study (ECCDS): results of drug treatment. Gastroenterology. 1984 Feb;86(2):249–266. [PubMed] [Google Scholar]
  138. Matthews N., Mayberry J. F., Rhodes J., Neale L., Munro J., Wensinck F., Lawson G. H., Rowland A. C., Berkhoff G. A., Barthold S. W. Agglutinins to bacteria in Crohn's disease. Gut. 1980 May;21(5):376–380. doi: 10.1136/gut.21.5.376. [DOI] [PMC free article] [PubMed] [Google Scholar]
  139. May J. J., Katilus J., Henson P. M., Dreisin R. B. The purification and identification of circulating immune complexes in tuberculosis. Am Rev Respir Dis. 1983 Nov;128(5):920–925. doi: 10.1164/arrd.1983.128.5.920. [DOI] [PubMed] [Google Scholar]
  140. Mayberry J. F., Rhodes J., Newcombe R. G. Familial prevalence of inflammatory bowel disease in relatives of patients with Crohn's disease. Br Med J. 1980 Jan 12;280(6207):84–84. doi: 10.1136/bmj.280.6207.84. [DOI] [PMC free article] [PubMed] [Google Scholar]
  141. McCallum D. I., Gray W. M. Metastatic Crohn's disease. Br J Dermatol. 1976 Nov;95(5):551–554. doi: 10.1111/j.1365-2133.1976.tb00868.x. [DOI] [PubMed] [Google Scholar]
  142. McClure H. M., Chiodini R. J., Anderson D. C., Swenson R. B., Thayer W. R., Coutu J. A. Mycobacterium paratuberculosis infection in a colony of stumptail macaques (Macaca arctoides). J Infect Dis. 1987 May;155(5):1011–1019. doi: 10.1093/infdis/155.5.1011. [DOI] [PubMed] [Google Scholar]
  143. McDonald G. B., Jewell D. P. Class II antigen (HLA-DR) expression by intestinal epithelial cells in inflammatory diseases of colon. J Clin Pathol. 1987 Mar;40(3):312–317. doi: 10.1136/jcp.40.3.312. [DOI] [PMC free article] [PubMed] [Google Scholar]
  144. McFadden J. J., Butcher P. D., Chiodini R., Hermon-Taylor J. Crohn's disease-isolated mycobacteria are identical to Mycobacterium paratuberculosis, as determined by DNA probes that distinguish between mycobacterial species. J Clin Microbiol. 1987 May;25(5):796–801. doi: 10.1128/jcm.25.5.796-801.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  145. McKenzie R. A., Donald B. A. Lymphadenitis in cattle associated with Corynebacterium equi: a problem in bovine tuberculosis diagnosis. J Comp Pathol. 1979 Jan;89(1):31–38. doi: 10.1016/0021-9975(79)90005-7. [DOI] [PubMed] [Google Scholar]
  146. McKenzie R. A., Ward W. H. Rhodococcus (Corynebacterium) equi: a possible cause of reactions to the complement fixation test for Johne's disease of cattle. Aust Vet J. 1981 Apr;57(4):200–201. doi: 10.1111/j.1751-0813.1981.tb00517.x. [DOI] [PubMed] [Google Scholar]
  147. McLaughlin C. A., Parker R., Hadlow W. J., Toubiana R., Ribi E. Moieties of mycobacterial mycolates required for inducing granulomatous reactions. Cell Immunol. 1978 Jun;38(1):14–24. doi: 10.1016/0008-8749(78)90027-8. [DOI] [PubMed] [Google Scholar]
  148. Mee A. S., Szawatakowski M., Jewell D. P. Monocytes in inflammatory bowel disease: phagocytosis and intracellular killing. J Clin Pathol. 1980 Oct;33(10):921–925. doi: 10.1136/jcp.33.10.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  149. Mekhjian H. S., Switz D. M., Watts H. D., Deren J. J., Katon R. M., Beman F. M. National Cooperative Crohn's Disease Study: factors determining recurrence of Crohn's disease after surgery. Gastroenterology. 1979 Oct;77(4 Pt 2):907–913. [PubMed] [Google Scholar]
  150. Merkal R. S., Larsen A. B. Clofazimine treatment of cows naturally infected with Mycobacterium paratuberculosis. Am J Vet Res. 1973 Jan;34(1):27–28. [PubMed] [Google Scholar]
  151. Merkal R. S., Larsen A. B., Kopecky K. E., Kluge J. P., Monlux W. S., Lehmann R. P., Quinn L. Y. Experimental paratuberculosis in sheep after oral, intratracheal, or intravenous inoculation: serologic and intradermal tests. Am J Vet Res. 1968 May;29(5):963–969. [PubMed] [Google Scholar]
  152. Merkal R. S., Monlux W. S., Kluge J. P., Larsen A. B., Kopecky K. E., Quinn L. Y., Lehmann R. P. Experimental paratuberculosis in sheep after oral, intratracheal, or intravenous inoculation: histochemical localization of dehydrogenase activities. Am J Vet Res. 1968 May;29(5):971–982. [PubMed] [Google Scholar]
  153. Merkal R. S., Richard J. L., Thurston J. R., Ness R. D. Effect of methotrexate on rabbits infected with Mycobacterium paratuberculosis or Dermatophilus congolensis. Am J Vet Res. 1972 Feb;33(2):401–407. [PubMed] [Google Scholar]
  154. Merkal R. S., Whipple D. L., Sacks J. M., Snyder G. R. Prevalence of Mycobacterium paratuberculosis in ileocecal lymph nodes of cattle culled in the United States. J Am Vet Med Assoc. 1987 Mar 15;190(6):676–680. [PubMed] [Google Scholar]
  155. Meyers S., Janowitz H. D. "Natural history" of Crohn's disease. An analytic review of the placebo lesson. Gastroenterology. 1984 Nov;87(5):1189–1192. [PubMed] [Google Scholar]
  156. Mitchell D. N., Rees R. J. Agent transmissible from Crohn's disease tissue. Lancet. 1970 Jul 25;2(7665):168–171. doi: 10.1016/s0140-6736(70)92532-8. [DOI] [PubMed] [Google Scholar]
  157. Mitchell D. N., Rees R. J. Further observations on the transmissibility of Crohn's disease. Ann N Y Acad Sci. 1976;278:546–559. doi: 10.1111/j.1749-6632.1976.tb47069.x. [DOI] [PubMed] [Google Scholar]
  158. Modlin R. L., Hofman F. M., Horwitz D. A., Husmann L. A., Gillis S., Taylor C. R., Rea T. H. In situ identification of cells in human leprosy granulomas with monoclonal antibodies to interleukin 2 and its receptor. J Immunol. 1984 Jun;132(6):3085–3090. [PubMed] [Google Scholar]
  159. Modlin R. L., Mehra V., Wong L., Fujimiya Y., Chang W. C., Horwitz D. A., Bloom B. R., Rea T. H., Pattengale P. K. Suppressor T lymphocytes from lepromatous leprosy skin lesions. J Immunol. 1986 Nov 1;137(9):2831–2834. [PubMed] [Google Scholar]
  160. Momotani E., Whipple D. L., Thiermann A. B., Cheville N. F. Role of M cells and macrophages in the entrance of Mycobacterium paratuberculosis into domes of ileal Peyer's patches in calves. Vet Pathol. 1988 Mar;25(2):131–137. doi: 10.1177/030098588802500205. [DOI] [PubMed] [Google Scholar]
  161. Morgan K. L. Johne's and Crohn's. Chronic inflammatory bowel diseases of infectious aetiology? Lancet. 1987 May 2;1(8540):1017–1019. doi: 10.1016/s0140-6736(87)92280-x. [DOI] [PubMed] [Google Scholar]
  162. Morganroth J., Watson D. W. Sensitivity to atypical mycobacterial antigens in patients with Crohn's disease. Am J Dig Dis. 1970 Jul;15(7):653–657. doi: 10.1007/BF02236026. [DOI] [PubMed] [Google Scholar]
  163. Morrison J. B. Natural history of segmental lesions in primary pulmonary tuberculosis: long-term review of 383 patients. Arch Dis Child. 1973 Feb;48(2):90–98. doi: 10.1136/adc.48.2.90. [DOI] [PMC free article] [PubMed] [Google Scholar]
  164. Ménard D. B., Haddad H., Blain J. G., Beaudry R., Devroede G., Massé S. Granulomatous myositis and myopathy associated with crohn's colitis. N Engl J Med. 1976 Oct 7;295(15):818–819. doi: 10.1056/NEJM197610072951506. [DOI] [PubMed] [Google Scholar]
  165. NIEDERLE B. [Regional ileitis in univitelline twins]. Arch Mal Appar Dig Mal Nutr. 1961 Nov;50:1245–1246. [PubMed] [Google Scholar]
  166. Nakamura M., Itoh T., Waki C. [Isolation of a cultivable mycobacterium from an armadillo subcutaneous tissue infected with M. leprae and characterization of this isolated strain (author's transl)]. Repura. 1976 Oct-Dec;45(4):217–222. doi: 10.5025/hansen1930.45.4_217. [DOI] [PubMed] [Google Scholar]
  167. Nash D. R., Douglass J. E. Anergy in active pulmonary tuberculosis. A comparison between positive and negative reactors and an evaluation of 5 TU and 250 TU skin test doses. Chest. 1980 Jan;77(1):32–37. doi: 10.1378/chest.77.1.32. [DOI] [PubMed] [Google Scholar]
  168. Navalkar R. G. Immunology of leprosy. Crit Rev Microbiol. 1980;8(1):25–47. doi: 10.3109/10408418009085077. [DOI] [PubMed] [Google Scholar]
  169. Nemir R. L., Cardona J., Vaziri F., Toledo R. Prednisone as an adjunct in the chemotherapy of lymph node-bronchial tuberculosis in childhood: a double-blind study. II. Further term observation. Am Rev Respir Dis. 1967 Mar;95(3):402–410. doi: 10.1164/arrd.1967.95.3.402. [DOI] [PubMed] [Google Scholar]
  170. Newman P. E., Goodman R. A., Waring G. O., 3rd, Finton R. J., Wilson L. A., Wright J., Cavanagh H. D. A cluster of cases of Mycobacterium chelonei keratitis associated with outpatient office procedures. Am J Ophthalmol. 1984 Mar;97(3):344–348. doi: 10.1016/0002-9394(84)90634-2. [DOI] [PubMed] [Google Scholar]
  171. Nugent F. W., Glaser D., Fernandez-Herlihy L. Crohn's colitis associated with granulomatous bone disease. N Engl J Med. 1976 Jan 29;294(5):262–263. doi: 10.1056/NEJM197601292940507. [DOI] [PubMed] [Google Scholar]
  172. Nuti M., D'Amelio R., Seminara R., Milano C. F., Palmisano L., Aiuti F. Circulating immune complexes detected by C1q solid phase assay in leprosy. Int J Lepr Other Mycobact Dis. 1981 Mar;49(1):27–30. [PubMed] [Google Scholar]
  173. Nyhlin H., Danielsson A. Incidence of Crohn's disease in a defined population in northern Sweden, 1974-1981. Scand J Gastroenterol. 1986 Dec;21(10):1185–1192. doi: 10.3109/00365528608996441. [DOI] [PubMed] [Google Scholar]
  174. Okabe N., Kuroiwa A., Fujita K., Shibuya T., Yao T., Okumura M. Immunological studies on Crohn's disease. VI. Increased chemiluminescent response of peripheral blood monocytes. J Clin Lab Immunol. 1986 Sep;21(1):11–15. [PubMed] [Google Scholar]
  175. Orme I. M., Collins F. M. Infection with Mycobacterium kansasii and efficacy of vaccination against tuberculosis. Immunology. 1983 Dec;50(4):581–586. [PMC free article] [PubMed] [Google Scholar]
  176. PAUSTIAN F. F., BOCKUS H. L. So-called primary ulcerohypertrophic ileocecal tuberculosis. Am J Med. 1959 Sep;27:509–518. doi: 10.1016/0002-9343(59)90016-6. [DOI] [PubMed] [Google Scholar]
  177. Pallen M. J. The immunological and epidemiological significance of environmental mycobacteria on leprosy and tuberculosis control. Int J Lepr Other Mycobact Dis. 1984 Jun;52(2):231–245. [PubMed] [Google Scholar]
  178. Paller A. S. Cutaneous changes associated with inflammatory bowel disease. Pediatr Dermatol. 1986 Dec;3(6):439–445. doi: 10.1111/j.1525-1470.1986.tb00647.x. [DOI] [PubMed] [Google Scholar]
  179. Pallone F., Montano S., Fais S., Boirivant M., Signore A., Pozzilli P. Studies of peripheral blood lymphocytes in Crohn's disease. Circulating activated T cells. Scand J Gastroenterol. 1983 Nov;18(8):1003–1008. doi: 10.3109/00365528309181833. [DOI] [PubMed] [Google Scholar]
  180. Pallone F., Squarcia O., Fais S., Boirivant M., Biancone L., Tonietti G. T cell differentiation antigens expressed by peripheral blood lymphocytes in Crohn's disease. Boll Ist Sieroter Milan. 1985;64(5):394–399. [PubMed] [Google Scholar]
  181. Palmer J. A., Watanakunakorn C. Mycobacterium kansasii pericarditis. Thorax. 1984 Nov;39(11):876–877. doi: 10.1136/thx.39.11.876. [DOI] [PMC free article] [PubMed] [Google Scholar]
  182. Paris J., Paris J. C., Claerbout J. F., Duval G., Lugand J. J. Résultats à distance du traitement de la Maladie de Crohn par la médication antituberculeuse. Lille Med. 1978 Aug-Sep;23(7):494–496. [PubMed] [Google Scholar]
  183. Paris J., Paris J. C., Simon V. Etude critique des effets de la médication antituberculeuse dans une série de 18 cas de formes sévères de maladie de Crohn. Lille Med. 1975 Apr;20(4):333–341. [PubMed] [Google Scholar]
  184. Patterson D. S., Allen W. M. Chronic mycobacterial enteritis in ruminants as a model of Crohn's disease. Proc R Soc Med. 1972 Nov;65(11):998–1001. [PMC free article] [PubMed] [Google Scholar]
  185. Pepin M., Marly J., Pardon P. Corynebacterium pseudotuberculosis infection in sheep and the complement fixation test for paratuberculosis. Vet Rec. 1987 Mar 7;120(10):236–236. doi: 10.1136/vr.120.10.236. [DOI] [PubMed] [Google Scholar]
  186. Pfreundschuh M., Bader B., Feurle G. E. T-lymphocyte subpopulations in Crohn's disease: definition by monoclonal antibodies. Klin Wochenschr. 1982 Nov 2;60(21):1369–1371. doi: 10.1007/BF01716217. [DOI] [PubMed] [Google Scholar]
  187. Phillpotts R. J., Hermon-Taylor J., Brooke B. N. Virus isolation studies in Crohn's disease: a negative report. Gut. 1979 Dec;20(12):1057–1062. doi: 10.1136/gut.20.12.1057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  188. Phillpotts R. J., Hermon-Taylor J., Teich N. M., Brooke B. N. A search for persistent virus infection in Crohn's disease. Gut. 1980 Mar;21(3):202–207. doi: 10.1136/gut.21.3.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  189. Portaels F., Asselineau C., Baess I., Daffé M., Dobson G., Draper P., Gregory D., Hall R. M., Imaeda T., Jenkins P. A. A cooperative taxonomic study of mycobacteria isolated from armadillos infected with Mycobacterium leprae. J Gen Microbiol. 1986 Oct;132(10):2693–2707. doi: 10.1099/00221287-132-10-2693. [DOI] [PubMed] [Google Scholar]
  190. Portaels F., De Ridder K., Pattyn S. R. Cultivable mycobacteria isolated from organs of armadillos uninoculated and inoculated with Mycobacterium leprae. Ann Inst Pasteur Microbiol. 1985 Mar-Apr;136A(2):181–190. doi: 10.1016/s0769-2609(85)80057-0. [DOI] [PubMed] [Google Scholar]
  191. Prendiville J. S., Cream J. J., Clifford Rose F., Scott J. T., Woodrow D. F., Waters M. F. Leprosy masked by steroids. Br Med J (Clin Res Ed) 1984 Mar 10;288(6419):770–771. doi: 10.1136/bmj.288.6419.770. [DOI] [PMC free article] [PubMed] [Google Scholar]
  192. Purrmann J., Cleveland S., Miller B., Strohmeyer G. Crohn's disease in a married couple. Hepatogastroenterology. 1987 Jun;34(3):132–133. [PubMed] [Google Scholar]
  193. Ramanathan V. D., Parkash O., Ramu G., Parker D., Curtis J., Sengupta U., Turk J. L. Isolation and analysis of circulating immune complexes in leprosy. Clin Immunol Immunopathol. 1984 Sep;32(3):261–268. doi: 10.1016/0090-1229(84)90270-8. [DOI] [PubMed] [Google Scholar]
  194. Ridell M. Crossreactivity between Mycobacterium leprae and various actinomycetes and related organisms. Int J Lepr Other Mycobact Dis. 1983 Jun;51(2):185–190. [PubMed] [Google Scholar]
  195. Ridell M. Immunodiffusion analyses of some diphtheroid organisms isolated from patients with leprosy. Int J Lepr Other Mycobact Dis. 1983 Jun;51(2):179–184. [PubMed] [Google Scholar]
  196. Roberts-Thomson I. C., Whittingham S., Youngchaiyud U., Mackay I. R. Ageing, immune response, and mortality. Lancet. 1974 Aug 17;2(7877):368–370. doi: 10.1016/s0140-6736(74)91755-3. [DOI] [PubMed] [Google Scholar]
  197. Routes J., Claman H. N. Corticosteroids in inflammatory bowel disease. A review. J Clin Gastroenterol. 1987 Oct;9(5):529–535. doi: 10.1097/00004836-198710000-00008. [DOI] [PubMed] [Google Scholar]
  198. Ruderman W. B., Farmer R. G. Current management of inflammatory bowel disease. Radiol Clin North Am. 1987 Jan;25(1):221–232. [PubMed] [Google Scholar]
  199. SCHOFIELD P. F. THE NATURAL HISTORY AND TREATMENT OF CROHN'S DISEASE. Ann R Coll Surg Engl. 1965 May;36:258–279. [PMC free article] [PubMed] [Google Scholar]
  200. Sachar D. B. Crohn's disease in Cleveland: a matter of life and death. Gastroenterology. 1985 Jun;88(6):1996–1998. doi: 10.1016/0016-5085(85)90030-7. [DOI] [PubMed] [Google Scholar]
  201. Sachar D. B., Taub R. N., Janowitz H. D. Editorial: A transmissible agent in Crohn's disease? New pursuit of an old concept. N Engl J Med. 1975 Aug 14;293(7):354–355. doi: 10.1056/NEJM197508142930712. [DOI] [PubMed] [Google Scholar]
  202. Sato H., Nakamatsu M., Fujimoto Y. The pathological study of paratuberculosis in goats, centered around the formation of remote lesions. Jpn J Vet Res. 1968 Dec;16(4):103–119. [PubMed] [Google Scholar]
  203. Scarlata G., Pellerito A. M., Di Benedetto M., Massenti M. F., Nastasi A. Isolation of Mycobacteria from drinking water in Palermo. Boll Ist Sieroter Milan. 1985;64(6):479–482. [PubMed] [Google Scholar]
  204. Schmitz-Moormann P., Pittner P. M., Malchow H., Brandes J. W. The granuloma in Crohn's disease. A bioptical study. Pathol Res Pract. 1984 May;178(5):467–476. doi: 10.1016/S0344-0338(84)80007-2. [DOI] [PubMed] [Google Scholar]
  205. Schraufnagel D. E., Leech J. A., Pollak B. Mycobacterium kansasii: colonization and disease. Br J Dis Chest. 1986 Apr;80(2):131–137. doi: 10.1016/0007-0971(86)90033-1. [DOI] [PubMed] [Google Scholar]
  206. Shaffer J. L., Hughes S., Linaker B. D., Baker R. D., Turnberg L. A. Controlled trial of rifampicin and ethambutol in Crohn's disease. Gut. 1984 Feb;25(2):203–205. doi: 10.1136/gut.25.2.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  207. Shah A. Evaluation of nerve function deficit. Its improvement by nerve decompression or corticosteroid therapy. Indian J Lepr. 1986 Apr-Jun;58(2):216–224. [PubMed] [Google Scholar]
  208. Shah I. C. Ileocecal tuberculosis and Crohn's disease. N Y State J Med. 1973 Apr 15;73(8):949–951. [PubMed] [Google Scholar]
  209. Sherman D. M., Gezon H. M. Comparison of agar gel immunodiffusion and fecal culture for identification of goats with paratuberculosis. J Am Vet Med Assoc. 1980 Dec 15;177(12):1208–1211. [PubMed] [Google Scholar]
  210. Sherman D. M., Markham R. J., Bates F. Agar gel immunodiffusion test for diagnosis of clinical paratuberculosis in cattle. J Am Vet Med Assoc. 1984 Jul 15;185(2):179–182. [PubMed] [Google Scholar]
  211. Shinnick T. M., Sweetser D., Thole J., van Embden J., Young R. A. The etiologic agents of leprosy and tuberculosis share an immunoreactive protein antigen with the vaccine strain Mycobacterium bovis BCG. Infect Immun. 1987 Aug;55(8):1932–1935. doi: 10.1128/iai.55.8.1932-1935.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  212. Sieber G., Herrmann F., Zeitz M., Teichmann H., Rühl H. Abnormalities of B-cell activation and immunoregulation in patients with Crohn's disease. Gut. 1984 Nov;25(11):1255–1261. doi: 10.1136/gut.25.11.1255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  213. Silva C. L., Brandão Filho S. L., Tincani I., Alves L. M. Cord factor is associated with the maintenance of the chronic inflammatory reaction caused by mycobacteria. J Gen Microbiol. 1986 Aug;132(8):2161–2165. doi: 10.1099/00221287-132-8-2161. [DOI] [PubMed] [Google Scholar]
  214. Simonowitz D., Block G. E., Riddell R. H., Kraft S. C., Kirsner J. B. The production of an unusual tissue reaction in rabbit bowel injected with Crohn's disease homogenates. Surgery. 1977 Aug;82(2):211–218. [PubMed] [Google Scholar]
  215. Singer H. C., Anderson J. G., Frischer H., Kirsner J. B. Familial aspects of inflammatory bowel disease. Gastroenterology. 1971 Oct;61(4):423–430. [PubMed] [Google Scholar]
  216. Singh G., Bhau L. N., Saxena S. N. Circulating immune complexes in pulmonary tuberculosis. Indian J Med Res. 1986 Feb;83:117–122. [PubMed] [Google Scholar]
  217. Sonnenberg A. Geographic variation in the incidence of and mortality from inflammatory bowel disease. Dis Colon Rectum. 1986 Dec;29(12):854–861. doi: 10.1007/BF02555363. [DOI] [PubMed] [Google Scholar]
  218. Sriyabhaya N., Wongwatana S. Pulmonary infection caused by atypical mycobacteria: a report of 24 cases in Thailand. Rev Infect Dis. 1981 Sep-Oct;3(5):1085–1089. doi: 10.1093/clinids/3.5.1085. [DOI] [PubMed] [Google Scholar]
  219. Sroat D. A. Ocular leprosy. Hawaii Med J. 1988 Feb;47(2):66–67. [PubMed] [Google Scholar]
  220. Stach J. L., Delgado G., Strobel M., Millan J., Lagrange P. H. Preliminary evidence of natural resistance to Mycobacterium bovis (BCG) in lepromatous leprosy. Int J Lepr Other Mycobact Dis. 1984 Jun;52(2):140–146. [PubMed] [Google Scholar]
  221. Summers R. W., Switz D. M., Sessions J. T., Jr, Becktel J. M., Best W. R., Kern F., Jr, Singleton J. W. National Cooperative Crohn's Disease Study: results of drug treatment. Gastroenterology. 1979 Oct;77(4 Pt 2):847–869. [PubMed] [Google Scholar]
  222. Tandon H. D., Prakash A. Pathology of intestinal tuberculosis and its distinction from Crohn's disease. Gut. 1972 Apr;13(4):260–269. doi: 10.1136/gut.13.4.260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  223. Taub R. N., Sachar D., Janowitz H., Siltzbach L. E. Induction of granulomas in mice by inoculation of tissue homogenates from patients with inflammatory bowel disease and sarcoidosis. Ann N Y Acad Sci. 1976;278:560–564. doi: 10.1111/j.1749-6632.1976.tb47070.x. [DOI] [PubMed] [Google Scholar]
  224. Thayer W. R., Jr, Coutu J. A., Chiodini R. J., Van Kruiningen H. J., Merkal R. S. Possible role of mycobacteria in inflammatory bowel disease. II. Mycobacterial antibodies in Crohn's disease. Dig Dis Sci. 1984 Dec;29(12):1080–1085. doi: 10.1007/BF01317079. [DOI] [PubMed] [Google Scholar]
  225. Thayer W. R., Jr Executive summary of the AGA-NFIC sponsored workshop on infectious agents in inflammatory bowel disease. Dig Dis Sci. 1979 Oct;24(10):781–784. doi: 10.1007/BF01317212. [DOI] [PubMed] [Google Scholar]
  226. Thayer W. R., Jr, Fixa B., Komarkova O., Charland C., Field C. E. Skin test reactivity in inflammatory bowel disease in the United States and Czechoslovakia. Am J Dig Dis. 1978 Apr;23(4):337–340. doi: 10.1007/BF01072417. [DOI] [PubMed] [Google Scholar]
  227. Tomasson H. O., Brennan M., Bass M. J. Tuberculosis and nonsteroidal anti-inflammatory drugs. Can Med Assoc J. 1984 Feb 1;130(3):275–278. [PMC free article] [PubMed] [Google Scholar]
  228. Touw Langendijk E. J., van Diepen T. W., Harboe M., Belehu A. Relation between anti-Mycobacterium leprae antibody activity and clinical features in borderline tuberculoid (BT) leprosy. Int J Lepr Other Mycobact Dis. 1983 Sep;51(3):305–311. [PubMed] [Google Scholar]
  229. Tsukamura M. Evidence that antituberculosis drugs are really effective in the treatment of pulmonary infection caused by Mycobacterium avium complex. Am Rev Respir Dis. 1988 Jan;137(1):144–148. doi: 10.1164/ajrccm/137.1.144. [DOI] [PubMed] [Google Scholar]
  230. Tytgat G. N., Mulder C. J. The aetiology of Crohn's disease. Int J Colorectal Dis. 1986 Jul;1(3):188–192. doi: 10.1007/BF01648449. [DOI] [PubMed] [Google Scholar]
  231. Van Kruiningen H. J., Chiodini R. J., Thayer W. R., Coutu J. A., Merkal R. S., Runnels P. L. Experimental disease in infant goats induced by a Mycobacterium isolated from a patient with Crohn's disease. A preliminary report. Dig Dis Sci. 1986 Dec;31(12):1351–1360. doi: 10.1007/BF01299814. [DOI] [PubMed] [Google Scholar]
  232. WARREN S., SOMMERS S. C. Cicatrizing enteritis as a pathologic entity; analysis of 120 cases. Am J Pathol. 1948 May;24(3):475–501. [PMC free article] [PubMed] [Google Scholar]
  233. WIG K. L., CHITKARA N. L., GUPTA S. P., KISHORE K., MANCHANDA R. L. Ileocecal tuberculosis with particular reference to isolation of Mycobacterium tuberculosis. With a note on its relation to regional ileitis (Crohn's disease). Am Rev Respir Dis. 1961 Aug;84:169–178. doi: 10.1164/arrd.1961.84.2.169. [DOI] [PubMed] [Google Scholar]
  234. Waldorf D. S., Willkens R. F., Decker J. L. Impaired delayed hypersensitivity in an aging population. Association with antinuclear reactivity and rheumatoid factor. JAMA. 1968 Mar 4;203(10):831–834. [PubMed] [Google Scholar]
  235. Wallace R. J., Jr, Swenson J. M., Silcox V. A., Good R. C., Tschen J. A., Stone M. S. Spectrum of disease due to rapidly growing mycobacteria. Rev Infect Dis. 1983 Jul-Aug;5(4):657–679. doi: 10.1093/clinids/5.4.657. [DOI] [PubMed] [Google Scholar]
  236. Wangel A. G., Wegelius O., Dyrting A. E. A family study of leprosy: subcutaneous amyloid deposits and humoral immune responses. Int J Lepr Other Mycobact Dis. 1982 Mar;50(1):47–55. [PubMed] [Google Scholar]
  237. Wemambu S. N., Turk J. L., Waters M. F., Rees R. J. Erythema nodosum leprosum: a clinical manifestation of the arthus phenomenon. Lancet. 1969 Nov 1;2(7627):933–935. doi: 10.1016/s0140-6736(69)90592-3. [DOI] [PubMed] [Google Scholar]
  238. Wendt S. L., George K. L., Parker B. C., Gruft H., Falkinham J. O., 3rd Epidemiology of infection by nontuberculous Mycobacteria. III. Isolation of potentially pathogenic mycobacteria from aerosols. Am Rev Respir Dis. 1980 Aug;122(2):259–263. doi: 10.1164/arrd.1980.122.2.259. [DOI] [PubMed] [Google Scholar]
  239. Weterman I. T., Peña A. S. Familial incidence of Crohn's disease in The Netherlands and a review of the literature. Gastroenterology. 1984 Mar;86(3):449–452. [PubMed] [Google Scholar]
  240. Whelan G., Farmer R. G., Fazio V. W., Goormastic M. Recurrence after surgery in Crohn's disease. Relationship to location of disease (clinical pattern) and surgical indication. Gastroenterology. 1985 Jun;88(6):1826–1833. doi: 10.1016/0016-5085(85)90007-1. [DOI] [PubMed] [Google Scholar]
  241. Whorwell P. J., Davidson I. W., Beeken W. L., Wright R. Search by immunofluorescence for antigens of Rotavirus, Pseudomonas maltophilia, and Mycobacterium kansasii in Crohn's disease. Lancet. 1978 Sep 30;2(8092 Pt 1):697–698. doi: 10.1016/s0140-6736(78)92700-9. [DOI] [PubMed] [Google Scholar]
  242. Whorwell P. J., Eade O. E., Hossenbocus A., Bamforth J. Crohn's disease in a husband and wife. Lancet. 1978 Jul 22;2(8082):186–187. doi: 10.1016/s0140-6736(78)91923-2. [DOI] [PubMed] [Google Scholar]
  243. Whorwell P. J., Phillips C. A., Beeken W. L., Little P. K., Roessner K. D. Isolation of reovirus-like agents from patients with Crohn's disease. Lancet. 1977 Jun 4;1(8023):1169–1171. doi: 10.1016/s0140-6736(77)92714-3. [DOI] [PubMed] [Google Scholar]
  244. Wilder W. M., Slagle G. W., Hand A. M., Watkins W. J. Crohn's disease of the epiglottis, aryepiglottic folds, anus, and rectum. J Clin Gastroenterol. 1980 Mar;2(1):87–91. doi: 10.1097/00004836-198003000-00013. [DOI] [PubMed] [Google Scholar]
  245. Williams S. E., Valenzuela I., Kadish A. S., Das K. M. Glomerular immune complex formation and induction of lymphoma in athymic nude mice by tissue filtrates of Crohn's disease patients. J Lab Clin Med. 1982 Jun;99(6):827–837. [PubMed] [Google Scholar]
  246. Williams S. M., Harned R. K. Hepatobiliary complications of inflammatory bowel disease. Radiol Clin North Am. 1987 Jan;25(1):175–188. [PubMed] [Google Scholar]
  247. Wirostko E., Johnson L., Wirostko B. Crohn's disease. Rifampin treatment of the ocular and gut disease. Hepatogastroenterology. 1987 Apr;34(2):90–93. [PubMed] [Google Scholar]
  248. Wolinsky E. Nontuberculous mycobacteria and associated diseases. Am Rev Respir Dis. 1979 Jan;119(1):107–159. doi: 10.1164/arrd.1979.119.1.107. [DOI] [PubMed] [Google Scholar]
  249. Worsaae N., Staehr Johansen K., Christensen K. C. Impaired in vitro function of neutrophils in Crohn's disease. Scand J Gastroenterol. 1982 Jan;17(1):91–96. doi: 10.3109/00365528209181050. [DOI] [PubMed] [Google Scholar]
  250. Yokomizo Y., Merkal R. S., Lyle P. A. Enzyme-linked immunosorbent assay for detection of bovine immunoglobulin G1 antibody to a protoplasmic antigen of Mycobacterium paratuberculosis. Am J Vet Res. 1983 Nov;44(11):2205–2207. [PubMed] [Google Scholar]
  251. Yoshimura H. H., Estes M. K., Graham D. Y. Search for evidence of a viral aetiology for inflammatory bowel disease. Gut. 1984 Apr;25(4):347–355. doi: 10.1136/gut.25.4.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  252. Yoshimura H. H., Graham D. Y., Estes M. K., Merkal R. S. Investigation of association of mycobacteria with inflammatory bowel disease by nucleic acid hybridization. J Clin Microbiol. 1987 Jan;25(1):45–51. doi: 10.1128/jcm.25.1.45-51.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  253. Yuan S. Z., Hanauer S. B., Kluskens L. F., Kraft S. C. Circulating lymphocyte subpopulations in Crohn's disease. Gastroenterology. 1983 Dec;85(6):1313–1318. [PubMed] [Google Scholar]
  254. Zuckerman M. J., Valenzuela I., Williams S. E., Kadish A. S., Das K. M. Persistence of an antigen recognized by Crohn's disease sera during in vivo passage of a Crohn's disease-induced lymphoma in athymic nude mice. J Lab Clin Med. 1984 Jul;104(1):69–76. [PubMed] [Google Scholar]
  255. van Eden W., Holoshitz J., Cohen I. Antigenic mimicry between mycobacteria and cartilage proteoglycans: the model of adjuvant arthritis. Concepts Immunopathol. 1987;4:144–170. [PubMed] [Google Scholar]

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