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. 1991 Apr;11(4):2303–2306. doi: 10.1128/mcb.11.4.2303

The C/EBP-binding region and adjacent sites regulate expression of the adipose P2 gene in human preadipocytes.

H S Ro 1, D A Roncari 1
PMCID: PMC359935  PMID: 2005913

Abstract

Human preadipocytes contain nuclear factors that specifically bind to the AE-1 sequence, previously demonstrated as an enhancer element in the regulation of adipose P2 gene expression during 3T3 adipose differentiation. By transient transfection and in vivo competition experiments, the trans-acting factors were found to bind either to the C/EBP recognition site in the AE-1 sequence and act as a negative regulator or to the adjacent site (termed 3' AE-1) and act as a positive regulator of adipose P2 gene activity in human preadipocytes.

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Selected References

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