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. 1990 Jan;10(1):397–400. doi: 10.1128/mcb.10.1.397

Copy choice mechanism of immunoglobulin heavy-chain switch recombination.

W Dunnick 1, J Stavnezer 1
PMCID: PMC360764  PMID: 2104661

Abstract

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated with donor and recipient constant-region genes. We have determined that the mutations which can be found in some switch regions after recombination appear to arise on only one strand of DNA. This result suggests that switch recombination involves error-prone synthesis of one DNA strand and ligation of the other strand from preexisting DNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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