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. 1990 Jul;10(7):3562–3568. doi: 10.1128/mcb.10.7.3562

Transformation of murine bone marrow cells with combined v-raf-v-myc oncogenes yields clonally related mature B cells and macrophages.

M Principato 1, J L Cleveland 1, U R Rapp 1, K L Holmes 1, J H Pierce 1, H C Morse 3rd 1, S P Klinken 1
PMCID: PMC360791  PMID: 2162474

Abstract

Murine bone marrow cells infected with replication-defective retroviruses containing v-raf alone or v-myc alone yielded transformed pre-B cell lines, while a retroviral construct containing both v-raf and v-myc oncogenes produced clonally related populations of mature B cells and mature macrophages. The genealogy of these transformants demonstrates that mature myeloid cells were derived from cells with apparent B-lineage commitment and functional immunoglobulin rearrangements. This system should facilitate studies of developmental relationships in hematopoietic differentiation and analysis of lineage determination.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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