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. 1990 Nov;10(11):6046–6050. doi: 10.1128/mcb.10.11.6046

Manipulations of cholinesterase gene expression modulate murine megakaryocytopoiesis in vitro.

D Patinkin 1, S Seidman 1, F Eckstein 1, F Benseler 1, H Zakut 1, H Soreq 1
PMCID: PMC361403  PMID: 2233731

Abstract

Megakaryocytopoiesis was selectively inhibited in cultured murine bone marrow cells by a 15-mer oligodeoxynucleotide complementary to the initiator AUG region in butyrylcholinesterase mRNA. Furthermore, conditioned medium from Xenopus oocytes producing recombinant butyrylcholinesterase stimulated megakaryocytopoiesis. These observations implicate butyrylcholinesterase in megakaryocytopoiesis and suggest application of oligodeoxynucleotides for modulating bone marrow development.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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