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. 1990 Sep;1(10):781–790. doi: 10.1091/mbc.1.10.781

Rat brain endoplasmic reticulum calcium pools are anatomically and functionally segregated.

A Verma 1, C A Ross 1, D Verma 1, S Supattapone 1, S H Snyder 1
PMCID: PMC361662  PMID: 1966012

Abstract

Autoradiographic imaging can localize 45Ca2+ selectively accumulated via the Ca2+, Mg2(+)-ATPase into endoplasmic reticulum stores in rat brain slices. 45Ca2+ accumulation is markedly stimulated by oxalate and displays a heterogeneous distribution which resembles the mRNA distribution for a sarcoendoplasmic reticulum Ca2+, Mg2(+)-ATPase. Inositol 1,4,5-triphosphate [I(1,4,5)P3] inhibits 45Ca2+ accumulation selectively into regions corresponding to those enriched in I(1,4,5)P3 receptor-binding sites and in Ca2+, -Mg2(+)-ATPase mRNA. Thus rat brain endoplasmic reticulum calcium stores are anatomically and functionally differentiated.

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Selected References

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