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. 1991 Dec;11(12):6041–6049. doi: 10.1128/mcb.11.12.6041

A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers.

T Morinaga 1, H Yasuda 1, T Hashimoto 1, K Higashio 1, T Tamaoki 1
PMCID: PMC361769  PMID: 1719379

Abstract

We have isolated a full-length cDNA encoding a protein (ATBF1) that binds to an AT-rich motif in the human alpha-fetoprotein gene enhancer. The amino acid sequence deduced from the cDNA revealed that this is the largest DNA-binding protein (306 kDa) known to date, containing four homeodomains, 17 zinc finger motifs, and a number of segments potentially involved in transcriptional regulation. Although the exact function of this protein has not been determined, these structural features suggest that ATBF1 plays a transcriptional regulatory role.

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