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. 1991 Jun;2(6):453–465. doi: 10.1091/mbc.2.6.453

sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.

Y Wang 1, M Boguski 1, M Riggs 1, L Rodgers 1, M Wigler 1
PMCID: PMC361829  PMID: 1883874

Abstract

Proper ras1 function is required for normal sexual function in the yeast Schizosaccharomyces pombe. We have found a gene in S. pombe, sar1, that encodes a product capable of regulating ras1 function. sar1 is a member of an expanding family of RAS GTPase-activating proteins (GAPs) that includes mammalian GAP, the yeast Saccharomyces cerevisiae IRA proteins, and the product of the human neurofibromatosis locus, NF1 sar1, like these other proteins, can complement the loss of IRA function in S. cerevisiae. Computer analysis shows that the highest degree of sequence conservation is restricted to a very small number of diagnostic residues represented by the motif Phe-Leu-Arg-X-X-X-Pro-Ala-X-X-X-Pro. We find no evidence that sar1 is required for the effector function of ras1.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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